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Risk Factors for Lead Toxicity and its Effect on Neurobehavior in Indian Children

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Abstract

Lead (Pb) is profoundly used heavy metal despite its known toxic effects. Children in particular are more susceptible to Pb toxicity. Thus, the present study was carried out to estimate the prevalence of lead toxicity in Indian children, to observe serum levels of biochemical parameters and to evaluate psychopathological implications of Pb toxicity using population specific scale—Childhood Psychopathological Measurement Schedule (CPMS) in children. Children between 9 and 15 years of age were included in the study (N = 70). Demographic details and information regarding the source of lead exposure were collected using a self-made questionnaire. All biochemical investigations were performed in Beckman Coulter Auto-analyser AU680 and Blood Lead Levels (BLL) were estimated by Graphite Furnace Atomic Absorption Spectrophotometer. The neurobehavioral state of the children was assessed by a population-specific scale i.e., CPMS, which evaluates for neurobehavior under 8 factors, titled, Low intelligence with behavioural problems, Conduct disorder, Anxiety, Depression, Psychotic symptoms, Special symptoms, Physical illness with emotional problems, and Somatization. The median BLL of the study population was 4.9 μg/dL. Habit of frequently consuming roadside food, proximity of residence to vehicular traffic and educational status of the mother were observed to be significant contributing factors for high BLL (≥ 5 μg/dL). Serum alkaline phosphatase (P = 0.02) and phosphorous levels (P = 0.04) were significantly lower in children belonging to high BLL group. A significantly high adverse neurobehavioral score was observed in high BLL group children compared to low BLL group (P < 0.05). There was high prevalence of Pb toxicity with 50% of children having BLL > 5 μg/dL. Further, certain lifestyle characteristics such as proximity of residence to vehicular traffic, frequent consumption of roadside food and lower educational status of the mother could be possible risk factors for higher Pb exposure in children. Evaluation of neurobehavior in children with high BLL revealed a high prevalence of adverse neurobehavior in them when compared to children in low BLL group.

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Data and materials of the study are available on request.

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Funding

The study was funded by the All India Institute of Medical Sciences, Jodhpur, Rajasthan.

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Author notes

  1. L. Malavika and Taru Goyal have equal contributions as first authors in the manuscript.

Authors and Affiliations

  1. Department of Biochemistry, All India Institute of Medical Sciences, Jodhpur, India

    L. Malavika, Taru Goyal, Gangam Saikiran, Shailja Sharma & Praveen Sharma

  2. Department of Biochemistry, Postgraduate Institute of Medical Education & Research (PGIMER), Chandigarh, India

    Prasenjit Mitra

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  1. L. Malavika
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  2. Taru Goyal
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Correspondence to Prasenjit Mitra.

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Ethical Approval

This study involves the participation of human subjects with the approval from the Institutional Ethical Committee (IEC), All India Institute of Medical Sciences, Jodhpur, Rajasthan India. (AIIMS/IEC/2018/640). The study was performed in accordance with down in the 1964 Declaration of Helsinki and its later amendments or comparable ethical standards.

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Malavika, L., Goyal, T., Mitra, P. et al. Risk Factors for Lead Toxicity and its Effect on Neurobehavior in Indian Children. Ind J Clin Biochem 37, 294–302 (2022). https://doi.org/10.1007/s12291-021-00995-w

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  • DOI: https://doi.org/10.1007/s12291-021-00995-w

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