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Non-HDL as a Valid Surrogate Marker of Small Dense LDL in a Young Indian Population

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Abstract

Small dense (sd) LDL is a significant independent risk factor for premature coronary artery disease (CAD). Unfortunately, its estimation is not popular, due to the limited availability of specialized equipment, high cost and time-consuming technique. Non-HDL is a calculated, single index measure of all atherogenic apolipoprotein-B containing lipoproteins. This study aimed at identifying non-HDL as a superior surrogate marker of sdLDL cholesterol in a young Indian population. 161 healthy subjects < 45 years were tested for lipid profile, apolipoproteins A1 and B, and sdLDL particle size. sdLDL particles showed negative correlation with non-HDL (r = − 0.283, p < 0.001), LDL (r = − 0.195, p = 0.013) and apoB/apo A1 (r = − 0.175, p = 0.026), the significance being greatest with non-HDL. ROC showed AUC for non-HDL, LDL and apoB/apo A1 as 0.704, 0.686, and 0.596 respectively. For LDL < 130 mg/dL, sdLDL showed a more significant negative correlation with non-HDL (r = − 0.291, p < 0.001) as compared with apoB/apoA1 (r = − 0.172, p = 0.037). For triglycerides < 200 mg/dL, sdLDL particle size showed higher significant negative correlation with non-HDL (r = − 0.213, p = 0.015) than with LDL (r = − 0.176, p = 0.045) while for triglycerides between 200 and 400 mg/dL, significant negative correlation was observed only with non-HDL (r = − 0.372, p = 0.043). Hence, our study suggested that non-HDL is a superior surrogate marker of sdLDL particle size as compared to LDL and apoB/A1 ratio in a young healthy Indian population and should be used for optimum assessment of dyslipidemias and CAD risk.

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Acknowledgements

This study was supported by a research grant from the Indian Council of Medical Research (ICMR), New Delhi, India.

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Authors and Affiliations

  1. Department of Biochemistry, Sir Ganga Ram Hospital, New Delhi, 110060, India

    Anjali Manocha, Seema Bhargava, Mamta Kankra & Parul Singla

  2. Department of Cardiology, Sir Ganga Ram Hospital, New Delhi, 110060, India

    Rajneesh Jain

  3. Department of Research, Sir Ganga Ram Hospital, New Delhi, 110060, India

    Parul Chugh

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  1. Anjali Manocha
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Correspondence to Anjali Manocha.

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Manocha, A., Bhargava, S., Jain, R. et al. Non-HDL as a Valid Surrogate Marker of Small Dense LDL in a Young Indian Population. Ind J Clin Biochem 34, 263–271 (2019). https://doi.org/10.1007/s12291-018-0758-6

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