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Age- and Gender-Specific Reference Intervals for Fasting Blood Glucose and Lipid Levels in School Children Measured With Abbott Architect c8000 Chemistry Analyzer

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Abstract

Reference intervals for pubertal characteristics are influenced by genetic, geographic, dietary and socioeconomic factors. Therefore, the aim of this study was to establish age-specific reference intervals of glucose and lipid levels among local school children. This was cross-sectional study, conducted among Saudi school children. Fasting blood samples were collected from 2149 children, 1138 (53%) boys and 1011 (47%) girls, aged 6 to 18 years old. Samples were analyzed on the Architect c8000 Chemistry System (Abbott Diagnostics, USA) for glucose, cholesterol, triglycerides, HDL and LDL. Reference intervals were established by nonparametric methods between the 2.5th and 97.5th percentiles. Significant differences were observed between boys and girls for cholesterol and triglycerides levels in all age groups (P < 0.02). Only at age 6–7 years and at adolescents, HDL and LDL levels were found to be significant (P < 0.001). No significant differences were seen in glucose levels except at age 12 to 13 years. Saudi children have comparable serum cholesterol levels than their Western counterparts. This may reflect changing dietary habits and increasing affluence in Saudi Arabia. Increased lipid screening is anticipated, and these reference intervals will aid in the early assessment of cardiovascular and diabetes risk in Saudi pediatric populations.

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Acknowledgments

We would like to thank all staff of King Abdullah International Medical Research Center (KAIMRC) and King Fahad National Guard Hospital for supporting this project. Special thanks to all of the research coordinators, assistants, nurses, phlebotomists and lab staff.

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Authors and Affiliations

  1. Department of Pathology & Laboratory Medicine, King Fahad National Guard Hospital, Riyadh, Saudi Arabia

    Waleed Tamimi

  2. Department of Pediatrics, Department of Family Medicine, King Fahad National Guard Hospital, Riyadh, Saudi Arabia

    Esam Albanyan

  3. Department of Biostatistics, Epidemiology and Scientific Computing, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia

    Yasmin Altwaijri

  4. College of Medicine King Saud Bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia

    Waleed Tamimi, Hani Tamim & Fahad Alhussein

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  1. Waleed Tamimi
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  2. Esam Albanyan
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  3. Yasmin Altwaijri
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  4. Hani Tamim
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  5. Fahad Alhussein
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Correspondence to Waleed Tamimi.

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Tamimi, W., Albanyan, E., Altwaijri, Y. et al. Age- and Gender-Specific Reference Intervals for Fasting Blood Glucose and Lipid Levels in School Children Measured With Abbott Architect c8000 Chemistry Analyzer. Ind J Clin Biochem 27, 141–146 (2012). https://doi.org/10.1007/s12291-012-0195-x

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  • DOI: https://doi.org/10.1007/s12291-012-0195-x

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