Skip to main content

Advertisement

SpringerLink
Log in

Study of Serum Homocysteine, Folic Acid and Vitamin B12 in Patients with Preeclampsia

  • Original Article
  • Published:
Indian Journal of Clinical Biochemistry Aims and scope Submit manuscript

Abstract

The present study was carried out to evaluate the occurrence of association between homocysteine, folic acid and vitamin B12 in patients with preeclampsia. Fifty preeclamptic patients from gynecology ward were studied for estimation of serum homocysteine, folic acid and vitamin B12 over a period of October 2007 to June 2010. Serum homocysteine and folic acid, and vitamin B12 were determined by means of Immulite 1000 analyzer. The statistical analysis of study group of preeclampsia compared with normotensive control group, showed significant alterations in serum homocysteine, folic acid and vitamin B12 concentrations in preeclampsia. Inverse association between serum homocysteine and folic acid, and vitamin B12 levels were observed in preeclampsia. The present study found hyperhomocysteinemia and deficiency of folic acid and vitamin B12 along with increased blood pressure as a risk factor for cardiovascular disease (CVD) in preeclampsia.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2

Similar content being viewed by others

References

  1. Saftlas AF, Olson DR, Franks L, Atrash HK, Pokras R. Epidemiology of preeclampsia and eclampsia in the United States 1979–86. Am J Obstet Gynecol. 1990;163:460–5.

    PubMed  CAS  Google Scholar 

  2. Barron WM, Murphy MB, Lindheimer MD. Management of hypertension during pregnancy. In: Laragh GH, Brenner BM, editors. Hypertension: pathophysiology, diagnosis and management. Raven: New York; 1990. p. 1809–27.

    Google Scholar 

  3. National high blood pressure education program working group report on high blood pressure in pregnancy. Am J Obstet Gynecol 1990; 163:1691–1712.

    Google Scholar 

  4. Nygard O, Nordrehaug JE, Refsum H, Ueland PM, Fastad M, Vollset SE. Plasma homocysteine levels and mortality in patients with coronary artery disease. N Engl J Med. 1997;337:230–6.

    Article  PubMed  CAS  Google Scholar 

  5. Wald DS, Law M, Morris JK. Homocysteine and cardiovascular disease: evidence on causality from a meta-analysis. Br Med J. 2002;325:1202–6.

    Article  Google Scholar 

  6. Voutilainen S, Rissanen TH, Virtanen J, Lakka TA, Salonen JT. Low dietary folic acid intake is associated with an excess incidence of acute coronary events: the Kuopio ischemic heart disease risk factor study. Circulation. 2001;103:2674–80.

    PubMed  CAS  Google Scholar 

  7. Klerk M, Verhoef P, Clarke R. MTHFR studies collaboration group. MTHFR 677C T polymorphism and risk of coronary heart disease: a meta-analysis. J Am Med Assoc. 2002;288:2023–31.

    Article  CAS  Google Scholar 

  8. Durga J, Bots ML, Schouten EG, Kok FJ, Verhoef P. Low concentrations of folic acid, not hyperhomocysteinemia, are associated with carotid intima-media thickness. Atherosclerosis. 2005;179:285–92.

    Article  PubMed  CAS  Google Scholar 

  9. Ueland PM, Refsum H, Stabler SP, Malinow MR, Andersson A, Allen RH. Total homocysteine in plasma or serum: methods and clinical applications. Clin Chem. 1993;39:1764–79.

    PubMed  CAS  Google Scholar 

  10. McNeely MDD. Folic acid assay. In: Kaplan LA, Pesce AJ, editors. Clinical chemistry. St. Louis: CV Mosby; 1984. p. 1402–6.

    Google Scholar 

  11. Allen RH. Clinical role and current status of serum cobalamin (vitamin B12) assays. Ligand Quarterly 1981 Fall; 4(3):37–44.

  12. Pi-Sunyer FX. Medical hazards of obesity. Ann Intern Med. 2000;160:2847–53.

    Article  Google Scholar 

  13. Walker MC, Smith GN, Perkins SL, Keely EJ, Garner PR. Changes in homocysteine levels during normal pregnancy. Am J Obstet Gynecol. 1999;180:660–4.

    Article  PubMed  CAS  Google Scholar 

  14. Hogg BB, Tamura T, Johnston KE, DuBard MB, Goldenberg MA, Goldenberg RL. Second-trimester plasma homocysteine levels and pregnancy-induced hypertension, preeclampsia, and intrauterine growth restriction. Am J Obstet Gynecol. 2000;183:805–9.

    Article  PubMed  CAS  Google Scholar 

  15. Vollset SE, Refsum H, Irgens LM, Emblem BM, Tverdal A, Gjessing HK, et al. Plasma total homocysteine, pregnancy complications, and adverse pregnancy outcomes: the Hordaland homocysteine study. Am J Clin Nutr. 2000;71:962–8.

    PubMed  CAS  Google Scholar 

  16. Bostom AG, Lathrop L. Homocysteinemia in end-stage renal disease: prevalence, etiology, and potential relationship to arteriosclerotic outcomes. Kidney Int. 1997;52:10–20.

    Article  PubMed  CAS  Google Scholar 

  17. Carmel R. Ethnic and racial factors in cobalamin metabolism and its disorders. Semin Hematol. 1999;36:88–100.

    PubMed  CAS  Google Scholar 

  18. Mignini L, Latthe P, Villar J, Kilby M, Carroli G, Khan K. Mapping the theories of preeclampsia: the role of homocysteine. Obstet Gynecol. 2005;105:411–25.

    Article  PubMed  CAS  Google Scholar 

  19. Lachmeijer AM, Arnigrimsson R, Bastiaans EJ, Pals G, ten Kate LP, de Vries JIP. Mutation in the gene for methylenetetrahydrofolate reductase, homocysteine levels and vitamin status in women with history of preeclampsia. Am J Obstet Gynecol. 2001;184:394–402.

    Article  PubMed  CAS  Google Scholar 

  20. Finkelstein JD. Methionine metabolism in mammals. J Nutr Biochem. 1990;1:228–37.

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Biochemistry, Grant Medical College and Sir J.J. Group of Government Hospitals, Mumbai, 400008, Maharashtra, India

    Shahid A. Mujawar & Vinayak W. Patil

  2. Department of Obstetrics and Gynecology, Grant Medical College and Sir J.J. Group of Government Hospitals, Mumbai, 400008, Maharashtra, India

    Rekha G. Daver

  3. Flat No-30, 7th Floor, Swstik-4, Sir J.J. Hospital Campus, Byculla, Mumbai, 400008, Maharashtra, India

    Shahid A. Mujawar

Authors
  1. Shahid A. Mujawar
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Vinayak W. Patil
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Rekha G. Daver
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Shahid A. Mujawar.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Mujawar, S.A., Patil, V.W. & Daver, R.G. Study of Serum Homocysteine, Folic Acid and Vitamin B12 in Patients with Preeclampsia. Ind J Clin Biochem 26, 257–260 (2011). https://doi.org/10.1007/s12291-011-0109-3

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s12291-011-0109-3

Keywords

Search

Navigation