Skip to main content
SpringerLink
Log in

Comparison Between Serum hsCRP and LDL Cholesterol for Search of a Better Predictor for Ischemic Heart Disease

  • Original Article
  • Published:
Indian Journal of Clinical Biochemistry Aims and scope Submit manuscript

Abstract

Acute myocardial Infarction is one of the major causes of morbidity & mortality in world and atherosclerosis is the major cause of ischemic heart disease. In order to determine the better clinical marker of atherosclerosis, we estimated serum low-density lipoprotein (LDL-C) and high sensitivity C-reactive protein (hsCRP). Hundred patients of myocardial infarction and 100 controls irrespective of age and sex were studied for these parameters over a period of 2 years. The statistical analysis showed that the serum hsCRP was significantly raised in myocardial infarction cases than controls (P < 0.01) but LDL-C was not (P > 0.05). We conclude that the serum hsCRP has better predictive value for risk of atherosclerosis.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Global Strategy on Diet, Physical Activity & Health. http://www.who.int/dietphysicalactivity/publications/facts/cvd/en.

  2. Kumar V, Abbas AK, Fausto N. Robbins and Cotran pathologic basis of disease. 3rd ed. Philadelphia: W.B. Saunder Company; 2007.

    Google Scholar 

  3. Libby P, Aikawa M. Stabilization of atherosclerotic plaques: new mechanisms and clinical targets. Nat Med. 2002;8:1257–62.

    Article  PubMed  CAS  Google Scholar 

  4. Libby P. Inflammation in atherosclerosis. Nature. 2002;420:868–74.

    Article  PubMed  CAS  Google Scholar 

  5. Expert Panel on Detection, Evaluation and Treatment of High Blood Cholesterol in Adults. Executive summary of the third report of the National Cholesterol Education Program (NCEP) expert panel on detection, evaluation, and treatment of high blood cholesterol in adults (Adult Treatment Panel III). JAMA. 2001;285:2486–97.

    Article  Google Scholar 

  6. Uotila M, Ruoslanti E, Enguall E. Two-site sandwich enzyme immunoassay with monoclonal antibodies to human alphafetoprotein. J Immunol Methods. 1981;42:11–5.

    Article  PubMed  CAS  Google Scholar 

  7. Pearson TA, Mensah GA, Alexander RW, Anderson JL, Fortmann SP, Hong Y, Myers GL, Rifai N, Smith SC Jr, Taubert K, Tracy RP, Vinicor F. Centers for disease control and prevention, American Heart Association: markers of inflammation and cardiovascular diseases application to clinical and public health practice: a statement for health care professionals from the Centre for Disease Control and Prevention and the American Heart Association. Circulation. 2003;107:499–511.

    Article  PubMed  Google Scholar 

  8. McPherson RA, Pincus MR. Henry’s clinical diagnosis and management by laboratory methods. 21st ed. New Delhi: Elsevier; 2007. p. 209.

    Google Scholar 

  9. Cuchel M, Rader DJ. Low density lipoprotein receptors and familial hypercholesterolemia in Clinical Studies in Clinical Biochemistry. 3rd ed. New York: Oxford University Press; 2007. p. 152–9.

    Google Scholar 

  10. Wilson PWF, D’Agostino RB, Levy D, Belanger AM, Silbeshatz H, Kannel WB. Prediction of coronary heart disease using risk factor categories. Circulation. 1998;97:1837–47.

    PubMed  CAS  Google Scholar 

  11. Lipid research clinics programme. The lipid research clinics coronary primary prevention trial results I; reduction in the incidence of coronary heart diseases. JAMA. 1984;251:351–64.

    Article  Google Scholar 

  12. Castelli WP. Cholesterol and lipids in the risk of coronary artery diseases-the Framingham heart study. Can J Cardiol. 1988;4(suppl):5A–10A.

    PubMed  Google Scholar 

  13. Austin MA, Breslow JL, Hennekens CH, Buring JE, Willett WC, Krauss RM. Low density lipoprotein subclass patterns and risk of myocvardial infarction. JAMA. 1988;260:1917–21.

    Google Scholar 

  14. Lanarche B, Tchernof A, Moorjani S, Cantin B, Dagenais G, Lupien P, Despres JP. Small density low density lipoprotein particles as a predictor of the risk of ischemic heart disease in men: prospective results from the Québec cardiovascular study. Circulation. 1997;95:69–75.

    Google Scholar 

  15. Krauss RM, Burke DJ. Identification of multiple subclasses of plasma low density lipoproteins in normal humans. J Lipid Res. 1982;23:97–104.

    PubMed  CAS  Google Scholar 

  16. Ridker PM. The pathogenesis of atherosclerosis and acute thrombosis relevance to strategies of cardiovascular disease prevention. In: Manson JE, Ridker PM, Gaziano JM, Hennekens CH, editors. Prevention of myocardial infarction. New York: Oxford University Press; 1996. p. 32–54.

    Google Scholar 

  17. Ridker PM. Inflammation, infection and cardiovascular risk: how good is the clinical evidence. Circulation. 1998;97:1671–4.

    PubMed  CAS  Google Scholar 

  18. Fauci AS, Kasper DL, Longo DL, Braunwald E, Hauser SL, Larry Jameson J, Loscalzo J. Harrison’s principles of internal medicine. 17th ed. New York: Mc Graw Hill Companies; 2008. p. 1502.

    Google Scholar 

  19. Pasceri V, Willerson JT, Yeh ETH. Direct proinflammatory effect of C-reactive protein on human endothelial cells. Circulation. 2000;102:2165–8.

    PubMed  CAS  Google Scholar 

  20. Yeh ETH, Anderson HV, Pasceri V, Willerson JT. C-reactive protein: linking inflammation to cardiovascular complications. Circulation. 2001;104:974–5.

    Article  PubMed  CAS  Google Scholar 

  21. Willerson JT. Systemic and local inflammation in patients with unstable atherosclerotic plaques. Prog Cardiovasc Dis. 2002;44:469–78.

    Article  PubMed  CAS  Google Scholar 

  22. Ridker PM, Hennekens CH, Roitman-Johnson B, Stampfer M, Allen J. Plasma concentration of soluble intercellular adhesion molecule 1 and risks of future myocardial infarction in apparently healthy men. Lancet. 1998;351:88–92.

    Article  PubMed  CAS  Google Scholar 

  23. Nakagomi A, Feedman SB, Geczy CL. Interferon and lipopolysaccharide potentiate monocyte tissue factor induction by C-reactive protein. Relationship with age, sex, and hormone replacement treatment. Circulation. 2000;101:1785–91.

    PubMed  CAS  Google Scholar 

  24. Verma S, Wang C-H, Li S-H, Dumont AS, Fedak PWM, Badiwala MV, et al. A self-fulfilling prophecy: C-reactive protein attenuates nitric oxide production and inhibits angiogenesis. Circulation. 2002;106:913–9.

    Article  PubMed  CAS  Google Scholar 

  25. Braunwald E. Sahttuck lecture-cardiovascular medicine at the turn of the millennium: triumph, concerns and opportunities. N Engl J Med. 1997;337:1360–9.

    Article  PubMed  CAS  Google Scholar 

  26. Blake GJ, Ridker PM. Novel clinical markers of vascular wall inflammation. Circ Res. 2001;89(9):763–71.

    Article  PubMed  CAS  Google Scholar 

  27. Blake GJ, Ridker PM. Inflammatory biomarkers and cardio-vascular risk prediction. J Intern Med. 2002;252(4):283–94.

    Article  PubMed  CAS  Google Scholar 

  28. D’Aiuto F, Casas JP, Shah T, Humphrics SE, Hingorani AD, Tonetti MS. C-reactive protein (+1444C>T) polymorphism influences CRP response following a moderate inflammatory stimulus. Atherosclerosis. 2005;179(2):413–7.

    Article  PubMed  Google Scholar 

  29. Sharma SB, Garg S, Veerwal A, Dwivedi S. hs-CRP and oxidative stress in young CAD patients. Ind J Clin Biochem. 2008;23(4):334–6.

    Article  CAS  Google Scholar 

  30. Rost NS, Wolf PA, Kase CS, Kelly-Hayes M, Silbershatz H, Massaro JM, D’Agostino RB, Franzblau C, Wilson PW. Plasma concentration of C-reactive protein and risk of ischaemic stroke and transient ischemic attack: the Framingham study. Stroke. 2001;32(11):2575–9.

    Article  PubMed  CAS  Google Scholar 

  31. Willerson JT, Ridker PM. Inflammation as a cardiovascular risk factor. Circulation. 2004;109:II2–II10. http://circ.ahajournals.org.

    Google Scholar 

  32. The emerging risk factors collaboration. C-reactive protein concentration and risk of coronary heart disease, stroke and mortality: an individual participant meta-analysis. Lancet. 2010;375:132–40.

    Article  Google Scholar 

  33. Levinson SS. Brief review and clinical examination of the use of hsCRP for cardiac risk assessment with the conclusion that it is premature to use this test. Clin Chim Acta. 2005;356(1–2):1–8.

    Article  PubMed  CAS  Google Scholar 

  34. Shalia KK, Shah VK, Mashru MR, Soneji SL, Vasvani JB, Payannavar SS, Walvalkar AP, Mokal RA, Mithbawkar SM, Kundalkar KV, Abraham A, Thakur PK. Circulating thrombotic and haemostatic components in patients with coronary artery disease. Ind J Clin Biochem. 2010;25(1):20–8.

    Article  Google Scholar 

  35. Ridker PM, Darielson E, Fonacca FA, Genest J, Gotto AM Jr, Kastelein JJ, Koehig W, Libby P, Lorenzatti AJ, Mac Fadyen JG, Nordestgaard BG, Shepherd J, Willerson JT, Glynn RJ. On behalves of JUPITER trial study group. Rosuvastatin to prevent vascular events in men and women with elevated CRP. N Engl J Med. 2008;359(21):2195–207.

    Article  PubMed  CAS  Google Scholar 

  36. Ridker PM, Darielson E, Fonacca FA, Genest J, Jr Gotto AM, Kastelein JJ, Koehig W, Libby P, Lorenzatti AJ, Mac Fadyen JG, Nordestgaard BG, Shepherd J, Willerson JT, Glynn RJ, On behalves of JUPITER trial study group. Reduction in CRP and LDL-C and cardiovascular event rates after initiation of rosuvastatin: a prospective study of the JUPITER trial. Lancet. 2009;373(9670):1175–82.

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Biochemistry, Katihar Medical College, Katihar, Bihar, India

    Subinay Datta, Zahidul Iqbal & K. R. Prasad

Authors
  1. Subinay Datta
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Zahidul Iqbal
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. K. R. Prasad
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to K. R. Prasad.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Datta, S., Iqbal, Z. & Prasad, K.R. Comparison Between Serum hsCRP and LDL Cholesterol for Search of a Better Predictor for Ischemic Heart Disease. Ind J Clin Biochem 26, 210–213 (2011). https://doi.org/10.1007/s12291-010-0100-4

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s12291-010-0100-4

Keywords

Search

Navigation