Abstract
Role of Vitamin D supplementation was studied in patients with hypertension. One hundred hypertensive patients (group I) were given conventional antihypertensive drugs while another 100 patients (group II), in addition, were supplemented with Vitamin D3 (33,000 IU, after every 2 weeks, for 3 months). Besides diastolic and systolic blood pressure, serum calcium, phosphorous, alkaline phosphatase, albumin, albumin-corrected calcium, and 24 h urinary creatinine levels were estimated in both the groups before the start of treatment and after 3 months. Vitamin D supplementation showed a more significant decrease in systolic blood pressure. This group also showed a significant increase in serum calcium as well as albumin-corrected calcium with a decrease in phosphorous. Results of the study confirm that Vitamin D supplementation has a role in reducing blood pressure in hypertensive patients and that it should be supplemented with the antihypertensive drugs. More extensive studies with a larger group, to draw a definite conclusion, are in progress.
This is a preview of subscription content, log in via an institution to check access.
References
Judd SE, Tangpricha V. Vitamin D deficiency and risk for cardiovascular disease. Am J Med Sci. 2009;338:40–4.
Ullah MI, Uwaifo GI, Nicholas WC, Koch CA. Does vitamin D deficiency cause hypertension? Current evidence from clinical studies and potential mechanisms. Int J Endocrinol. 2010. doi:10.1155/2010/579640.
Rostand SG. Ultraviolet light may contribute to geographic and racial blood pressure differences. Hypertension. 1997;30:150–6.
Scragg R, Sowers M, Bell C. Serum 25-hydroxyvitamin D, ethnicity, and blood pressure in the Third National Health and Nutrition Examination Survey. Am J Hypertens. 2007;20:713–9.
Forman JP, Giovannucci E, Holmes MD. Plasma 25-hydroxyvitamin D levels and risk of incident hypertension. Hypertension. 2007;49:1063–9.
Connerty HV, Briggs AR. Determination of serum calcium by means of orthocresolphthalein complexone. Am J Clin Pathol. 1966;45:200–6.
Atkinson A, Gatenby AD, Lowe AG. The determination of inorganic orthophosphate in biological systems. Biochim Biophys Acta. 1973;320:195–204.
Moss DW, Whitby LG. A simplified method for investigating alkaline phosphatase isoenzymes in serum. Clin Chim Acta. 1972;40:35–41.
Doumas BT, Peters T. Serum and urine albumin: a progress report on their measurement and clinical significance. Clin Chem Acta. 1997;258:3–20.
Newman DJ, Price CP. Renal function and nitrogen metabolites. In: Burtis CA, Ashwood ER, editors. Teitz’s textbook of clinical chemistry. 3rd ed. Philadelphia: WB Saunders; 1999. p. 1204–1210.
Payne RB, Little AJ, Evans RY. Albumin-adjusted calcium concentration in serum increases during normal pregnancy. Clin Chem. 1990;36:142–4.
Martins D, Wolf M, Pan D. Prevalence of cardiovascular risk factors and the serum levels of 25-hydroxyvitamin D in the United States: data from the Third National Health and Nutrition Examination Survey. Arch Intern Med. 2007;167:1159–65.
Pfeifer M, Begerow B, Minne WH, Nachtigall D, Hansen C. Effects of a short-term vitamin D3 and calcium supplementation on blood pressure and parathyroid hormone levels in elderly women. J Clin Endocrinol Metab. 2001;86:1633–7.
Li YC, Qiao G, Uskokovic M, Xiang W, Zheng W, Kong J. Vitamin D: a negative endocrine regulator of the rennin-angiotensin system and blood pressure. J Steroid Biochem Mol Biol. 2004;89–90:387–92.
Resnick L. The cellular ionic basis of hypertension and allied clinical conditions. Prog Cardiovasc Dis. 1999;42:1–22.
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Goel, R.K., Lal, H. Role of Vitamin D Supplementation in Hypertension. Ind J Clin Biochem 26, 88–90 (2011). https://doi.org/10.1007/s12291-010-0092-0
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s12291-010-0092-0