Abstract
The present study was designed to evaluate the lipid peroxidation and non-enzymatic antioxidants in pregnancyinduced hypertension (PIH) compared with healthy normal pregnant and non-pregnant as controls. 75 cases were studied of which 25 were normal healthy controls (Group A), 25 healthy pregnant women (Group B) of third trimester and 25 were PIH (Group C) of the same trimester. In PIH, malondialdehyde a lipid peroxidation product was significantly increased as compared to normal pregnant and non-pregnant controls. The nonenzymatic antioxidants like reduced glutathione, Vitamin-E, Vitamin-C and Vitamin-A were significantly decreased in normal pregnants as compared to controls. A further significant decrease was noticed in PIH compared to normal pregnants. A significant negative correlation was detected between lipid peroxidation and non-enzymatic antioxidant levels. Our study clearly indicates a relationship between elevated lipid peroxidation, decreased non-enzymatic antioxidant in PIH. The measurement of non-enzymatic antioxidants in plasma may be useful predictor of the likely development of PIH.
Similar content being viewed by others
References
Tang LC, Kwok AC, Wong AY, Lee YY, Sun KO, So AP. Critical care in obstetrical patients: an eight year review. Chin Med J 1997; 110: 936–941.
Kamath S. Hypertension in pregnancy. JAPI. 2006; 54: 269–270.
Sies H. Biochemistry of oxidative stress. Angew Chem Int ed Engl 1986; 25: 1058–1071.
Ishihara M. Studies on lipoperoxide of normal pregnant women and of patients with toxaemia of pregnancy. Clin Chem Acta 1978; 84: 1–9.
American college of obstetrics and gynecologists. Management of pre-eclampsia. Technical bulletin No.1. Washington, DC; American college of obstetrics and gynecologists, 1986.
Yagi K. Assay for lipid peroxide level and its clinical significance. In Yagi K editor lipid peroxides in Biology and Medicine New York. 1982; 233–242.
Beutler E, West C, Blum KG. The removal of leukocytes and platelets in whole blood. J Lab Clin Med 1976; 88(2): 328–333.
Quaife ML, Scrimschow NS and Lowary OH. Micro method for assay of total tocopherol in blood serum. J Biol Chem 1949; 80: 1229–1235.
Evelyn KA, Malloy HT, Rosen C. The determination of ascorbic acid by photoelectric colorimeter. J Biol Chem 1938; 126: 645–654.
Bessey OA, Lowary OH, Brock MJ, Lopez. The determination of Vitamin-A and carotene in small quantities of blood serum. J Biol Chem 1946; 186: 177–188.
Scott Walsh. Lipid Peroxidation in Pregnancy. Hypertension in Pregnancy 1994; 13(1): 1–32.
Wickens D. Free radical oxidation (peroxidation) products in plasma in normal and abnormal pregnancy. Ann Clin Biochem 1981; 18: 158–162.
Hubel CA, James M, Robert MD. Lipid peroxidation in pregnancy: New perspectives on pre-eclampsia. Am J Obs Gyne 1989; 161: 1025–1034.
Kharb S. Evaluation of oxidative stress in pre-eclampsia. The Journal of Obs Gyne Ind 2000; 50(3): 56–58.
Kumar CA, Das UN. Oxidant stress in pre-eclampsia and essential hypertension. J Assoc Physicians India 2002; 50: 1372–1375.
Knapen MF, Mulder TP, Rooij Van IA, Peters WH, Steegers EA. Low whole blood glutathione levels in pregnancies complicated by pre-eclampsia or the hemolysis, elevated liver enzymes, low platelets syndrome. Obs Gyne 1998; 92: 1012–1015.
Pyska W, Klejewski A, Karolkiewicz, Imbalance of prooxidants — antioxidants in blood of pregnant women with pregnancy induced hypertension. Ginekol Pol 2002; 72(1): 14–18.
Kharb S. Vitamin-E and Vitamin-C in pre-eclampsia. Eur J Obs Gyne Reprod Biol 2000; 93(1): 37–39.
Madzali R, Benian, Gumustas K, Uzun H, Ocak V, Aksu F. Lipid peroxidation and antioxidants in pre-eclampsia. Eur J Obs Gyne Reprod Biol 1999; 85: 205–208.
Magady SM, Akolisa Anyaebunam, Garfink D. Pre-eclampsia and antioxidant nutrients: Decreased plasma levels of reduced ascorbic acid, α-tocopherol, and β-carotene in women with pre-eclampsia. Am J Obs Gyne 1994; 171: 150–157.
YHK Yon Kim, BWA Song AHN, SYY Sung Yang, Lipid peroxides: Total peroxyl radical trapping ability and antioxidant Vitamins of maternal venous blood plasma in pre-eclampsia. Am J Obs Gyne 2001; 185(Suppl 6): 171.
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Patil, S.B., Kodliwadmath, M.V. & Kodliwadmath, S.M. Correlation between lipid peroxidation and non-enzymatic antioxidants in pregnancy induced hypertension. Indian J Clin Biochem 23, 45–48 (2008). https://doi.org/10.1007/s12291-008-0011-9
Published:
Issue Date:
DOI: https://doi.org/10.1007/s12291-008-0011-9