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First Observation of Hb Lepore Hollandia in the Baiga Tribal Family

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References

  1. Bozkurt G, Baysal E, Gu L-H, Huisman THJ (1994) Thalassemia intermedia in two patients with Hb Lepore-β0-thalassemia (Frameshift codon 8,-AA). Hemoglobin 18(3):247–250

    Article  PubMed  CAS  Google Scholar 

  2. Chakova L, Spasova M, Genev E (1998) Thalassemia intermedia in an infant. Folia Med 40(1):84–87

    CAS  Google Scholar 

  3. Sreedharanunni S, Chhabra S, Kaur JH, Bansal D, Sharma P, Das R (2015) β-thalassemia intermedia caused by compound heterozygosity for Hb Lepore-Hollandia and β-thalassemia is rare in the Indian Population. Hemoglobin 39(5):362–365

    PubMed  CAS  Google Scholar 

  4. Labie D, Schroeder WA, Huisman THJ (1966) The amino acid sequence of the δ-β chains of Hemoglobin Lepore-Augusta = Lepore Washington. Biochim Biophys Acta 127(2):428–437

    Article  PubMed  CAS  Google Scholar 

  5. Ostertag W, Smith EW (1969) Hemoglobin-Lepore-Baltimore, a third type of a δβ crossover (δ50, β86). Eur J Biochem 10(2):371–376

    Article  PubMed  CAS  Google Scholar 

  6. Ribeiro ML, Cunha E, Gonçalves P et al (1997) Hb Lepore-Baltimore (δ68Leu-β84Thr) and Hb Lepore-Washington-Boston (δ87Gln-βIVS-II-8) in central Portugal and Spanish Alta Extremadura. Hum Genet 99(5):669–673

    Article  PubMed  CAS  Google Scholar 

  7. Barnabas J, Muller CJ (1962) Hemoglobin-Lepore Hollandia. Nature 194:931–932

    Article  CAS  Google Scholar 

  8. Viprakasit V, Pung-Amritt P, Suwanthon L et al (2002) Complex interactions of db hybrid hemoglobin (Hb Lepore-Hollandia) Hb E (β26(G→A)) and α+ thalassemia in a Thai family. Eur J Hematol 68(2):107–111

    Article  CAS  Google Scholar 

  9. Ghosh K, Colah RB, Mukherjee MB (2015) Haemoglobinopathies in tribal populations of India. Indian J Med Res 141(5):505–508

    PubMed  PubMed Central  Google Scholar 

  10. Chouhan D, Sharma R, Valki B, Parekh J (1971) Hemoglobin Lepore in an Indian Family. J Indian Med Assoc 56:287–290

    PubMed  CAS  Google Scholar 

  11. Ropero P, Gonzalez FA, Sanchez J, Anguita E, Asenjo S, Del Acro A, Murga MJ, Ramos R, Fernandez C, Villegas A (1999) Identification of Hb Lepore phenotype by HPLC. Haematologica 84:1081–1084

    PubMed  CAS  Google Scholar 

  12. Wonkam A, Ngo Bitoungui VJ, Vorster AA, Ramesar R, Cooper RS, Tayo B et al (2014) Association of variants at BCL11A and HBS1L-MYB with hemoglobin F and hospitalization rates among sickle cell patients in Cameroon. PLoS ONE 9(3):e92506. https://doi.org/10.1371/journal.pone.0092506

    Article  PubMed  PubMed Central  CAS  Google Scholar 

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Author notes

  1. Harsha Lad and Manju Yadav have contributed equally to this work.

Authors and Affiliations

  1. National Institute for Research in Tribal Health (Indian Council of Medical Research), Nagpur Road, Jabalpur, Madhya Pradesh, 482003, India

    Harsha Lad, Purushottam Patel & Rajasubramaniam Shanmugam

  2. National Institute of Immunohaematology (NIIH), Indian Council of Medical Research (ICMR), 13th Floor, K.E.M Hospital Campus, Parel, Mumbai, 400012, India

    Manju Yadav, Pallavi Mehta, Pratibha Sawant, Roshan B. Colah & Malay B. Mukherjee

Authors
  1. Harsha Lad
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  2. Manju Yadav
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  3. Pallavi Mehta
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  4. Purushottam Patel
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  5. Pratibha Sawant
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  6. Roshan B. Colah
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  7. Malay B. Mukherjee
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  8. Rajasubramaniam Shanmugam
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Corresponding author

Correspondence to Rajasubramaniam Shanmugam.

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Conflict of interest

The authors declare no conflict of interest.

Ethical Standards

Study was approved by Institutional Ethics Committee. All procedures performed in the study involving human participants were in accordance with the ethical standards of the institutional research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

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Informed consent was obtained from all individual participants included in the study.

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Lad, H., Yadav, M., Mehta, P. et al. First Observation of Hb Lepore Hollandia in the Baiga Tribal Family. Indian J Hematol Blood Transfus 34, 581–584 (2018). https://doi.org/10.1007/s12288-018-0931-3

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  • DOI: https://doi.org/10.1007/s12288-018-0931-3

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