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Familial Pelger–Huet Anomaly

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Indian Journal of Hematology and Blood Transfusion Aims and scope Submit manuscript

Abstract

Pelger–Huet anomaly is usually autosomal dominant, although it is likely that new mutations are common. This condition is characterized by granulocytes that are either bilobed or completely unsegmented. Here is a report of a 46 year old Indian lady who presented with fever to the hospital and on evaluation, her peripheral blood smear showed extreme hypolobation of granulocytes. Along with normal appearing neutrophils there were many neutrophils with bilobed and single monolobated nuclei which accounted for 82 % of the neutrophils. After identifying these neutrophilic abnormalities which were suggestive of Pelgeroid changes, the other family members were also screened and were found to be having similar morphologic abnormalities in granulocytes. As these changes were evident in granulocytic leucocytes of the patient as well as her mother, both her sisters and her son, with exception of her brother, the diagnosis of familial Pelger–Huet Anomaly was considered in this case.

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References

  1. O’Malley D, Hsi E (2007) Non neoplastic morphologic abnormalities of white blood cells and macrophages. In: Goldblum J (ed) Hematopathology, a volume in the series foundations in diagnostic pathology, 1st edn. Elsevier, Philadelphia, pp 55–66

    Google Scholar 

  2. Al-Qaddomi A, Bassma H, Wraikat A et al (2006) Pelger –Huet anomaly first report from Jordan. A case report. JRMS 13(2):54–56

    Google Scholar 

  3. Yamasoma Y, Fujji T, Tsuchiatori K (1953) The Pelger–Huet familial anomaly of leukocytes. Blood 8:370–374

    Google Scholar 

  4. Johnson CA, Bass D, Trilloy A et al (1980) Functional and metabolic studies of polymorphonuclear leucocytes in the congenital Pelger –Huet anomaly. Blood 55(3):466–469

    CAS  PubMed  Google Scholar 

  5. Rosse W, Gurney C (1959) The Pelger–Huet anomaly in three families and its use in determining the disappearance of transfused neutrophils from the peripheral blood. Blood 14:170–186

    CAS  PubMed  Google Scholar 

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Authors and Affiliations

  1. Laboratory, Bhatia Hospital, 2nd Floor, Tukaram Javji Road, Tardeo, Mumbai, 400007, India

    Samir S. Shah, Rupali S. Parikh, Lakshmi P. Vaswani & Rajeshree Divkar

Authors
  1. Samir S. Shah
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  2. Rupali S. Parikh
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  3. Lakshmi P. Vaswani
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  4. Rajeshree Divkar
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Corresponding author

Correspondence to Samir S. Shah.

Additional information

Communicated by Haraprasad Pati.

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Shah, S.S., Parikh, R.S., Vaswani, L.P. et al. Familial Pelger–Huet Anomaly. Indian J Hematol Blood Transfus 32 (Suppl 1), 347–350 (2016). https://doi.org/10.1007/s12288-015-0508-3

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  • DOI: https://doi.org/10.1007/s12288-015-0508-3

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