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Metastasis of Solid Tumors in Bone Marrow: A Study from Northern India

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Indian Journal of Hematology and Blood Transfusion Aims and scope Submit manuscript

Abstract

The metastasis of bone marrow by the solid tumors is a sign of advanced stage of disease and poor prognosis. The aim of this study was to assess the pattern of bone marrow involvement of different solid tumors and their correlation with hematological findings. In a retrospective study we evaluated 434 aspirates and 76 biopsy sections from 124 cases of different types of solid tumors previously diagnosed on the basis of their clinical and histopathological findings. The hematological profile of the patients was done and correlated with the bone marrow findings. The study was carried out at a medical college hospital of northern India. Out of 124 cases of solid tumors 31 (25%) have metastasized to bone marrow. The highest number 25 (36%) of bone marrow involvement was seen in carcinoma prostate followed by gastric carcinoma and melanoma (25%) The least number (14.2%) cases of bone marrow metastasis were observed in endometrial carcinoma. Anemia was found the commonest (71.4%) hematological finding followed by thrombocytopenia in 45.1% cases. The bone marrow examination is an easy, convenient, sensitive and cost effective procedure for assessment of staging and monitoring of prognosis of solid tumors.

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Author notes

  1. Syed Riaz Mehdi

    Present address: Department of Medical Laboratory, Medical College of Health (Men), King Saud University, Riyadh, India

  2. Madan Lal Brahma Bhatt

    Present address: Department of Radiotherapy, C.S.M Medical University, Lucknow, India

Authors and Affiliations

  1. Department of Pathology JNMC, AMU, Aligarh, India

    Syed Riaz Mehdi

  2. Department of Radiotherapy, JNMC, AMU, Aligarh, India

    Madan Lal Brahma Bhatt

Authors
  1. Syed Riaz Mehdi
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  2. Madan Lal Brahma Bhatt
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Corresponding author

Correspondence to Syed Riaz Mehdi.

Additional information

The work was carried out at Department of Pathology and Radiotherapy, JN Medical College, AMU, Aligarh, UP, India.

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Mehdi, S.R., Bhatt, M.L.B. Metastasis of Solid Tumors in Bone Marrow: A Study from Northern India. Indian J Hematol Blood Transfus 27, 93–95 (2011). https://doi.org/10.1007/s12288-011-0069-z

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  • DOI: https://doi.org/10.1007/s12288-011-0069-z

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