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Autoimmune Lymphoproliferative Syndrome: Response to Mycophenolate Mofetil and Pyrimethamine/Sulfadoxine in a 5-Year-Old Child

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Indian Journal of Hematology and Blood Transfusion Aims and scope Submit manuscript

Abstract

Autoimmune Lymphoproliferative Syndrome (ALPS) is a rare inherited disorder of disrupted lymphocyte homeostasis characterized by chronic splenomegaly and lymphadenopathy of early onset, hypergammaglobulinemia (Ig G and Ig A), autoimmune phenomena, and expanded populations of TCR-α/β+, CD3+, CD4-, CD8-T cells (Fisher et al. Cell 81:935–946; 1995), called double negative T-cells [(DN) T cells]. We discuss a case of ALPS which showed good response to immunosuppressant drug Mycophenolate-Mofetil in combination with Pyrimethamine/Sulfadoxine.

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Acknowledgments

We would like to acknowledge, Dr. Vikram Mathews and Ms Reena Rajasekhar for processing the Immunophenotyping sample at Christian Medical College, Vellore.

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Authors and Affiliations

  1. Department of Pediatrics, Christian Medical College, Ludhiana, Punjab, India

    Sunaina Arora, Neeraj Singh & Gurmeet Kaur Chaudhary

  2. Department of Clinical Hematology and Hemato-Oncology & Bone Marrow Transplant Unit, Christian Medical College, Ludhiana, India

    M. Joseph John

Authors
  1. Sunaina Arora
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  2. Neeraj Singh
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  3. Gurmeet Kaur Chaudhary
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  4. M. Joseph John
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Correspondence to Neeraj Singh.

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Arora, S., Singh, N., Chaudhary, G.K. et al. Autoimmune Lymphoproliferative Syndrome: Response to Mycophenolate Mofetil and Pyrimethamine/Sulfadoxine in a 5-Year-Old Child. Indian J Hematol Blood Transfus 27, 101–103 (2011). https://doi.org/10.1007/s12288-011-0058-2

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  • DOI: https://doi.org/10.1007/s12288-011-0058-2

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