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Serum Immunoglobulins in Patients with Iron Deficiency Anemia

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Indian Journal of Hematology and Blood Transfusion Aims and scope Submit manuscript

Abstract

Iron deficiency is a common cause of anemia worldwide. Documentation shows that these patients have impaired immunity and are prone to infections. The aim of this study was to confirm whether serum immunoglobulins change in adult nonpregnant females with iron deficiency anemia. Based on patients’ clinical history, CBC results, and serum ferritin, iron and total iron binding capacity, 45 healthy patients and 45 iron deficiency anemia (hypochrom microcytic) patients were entered into this case–control study. Serum IgG, IgA and IgM were measured in patient and control groups using the nephelometry method. Both of the groups were compared using suitable statistical test. Mean serum values of IgG, IgA and IgM in the patient group were 12.47 ± 7.67, 1.93 ± 0.92 and 1.35 ± 0.90 g/l respectively. Mean serum values for the control group were 12.51 ± 6.85, 2.14 ± 0.88 and 1.49 ± 0.73 g/l respectively. Although serum immunoglobulins were slightly lower in the patient group compared to the control group these differences were not significant with the t test. Our study showed serum immunoglobulin levels did not change in iron deficiency anemia.

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References

  1. Beutler E (2006) Disorders of iron metabolisms. In: Lichtman MA, Beutler E, Kipps TJ (eds) Williams hematology, 7th edn. McGraw-Hill, New York, pp 511–518

    Google Scholar 

  2. Boy E, Mannar V, Pandav C et al (2009) Achievements, challenges, and promising new approaches in vitamin and mineral deficiency control. Nutr Rev 67(Suppl 1):S24–S30

    Article  PubMed  Google Scholar 

  3. Andrews NC (2003) Iron deficiency and related disorders. In: Greer JP, Foerster J, Lukens JN (eds) Wintrobe’s clinical hematology, 11th edn. Lippincott Williams and Wilkins, New York, p 990

    Google Scholar 

  4. Grondin MA, Ruivard M, Perrève A et al (2008) Prevalence of iron deficiency and health-related quality of life among female students. J Am Coll Nutr 27:337–341

    PubMed  Google Scholar 

  5. Al Khatib L, Obeid O, Sibai AM et al (2006) Folate deficiency is associated with nutritional anaemia in Lebanese women of childbearing age. Public Health Nutr 9:921–927

    PubMed  Google Scholar 

  6. Mehta BC (2004) Iron deficiency amongst nursing students. Indian J Med Sci 58:389–393

    CAS  PubMed  Google Scholar 

  7. Keskin Y, Moschonis G, Dimitriou M et al (2005) Prevalence of iron deficiency among schoolchildren of different socio-economic status in urban Turkey. Eur J Clin Nutr 59:64–71

    Article  CAS  PubMed  Google Scholar 

  8. Hercberg S, Preziosi P, Galan P (2001) Iron deficiency in Europe. Public Health Nutr 4:537–545

    Article  CAS  PubMed  Google Scholar 

  9. Stoltzfus RJ (2001) Iron-deficiency anemia: reexamining the nature and magnitude of the public health problem. Summary: implications for research and programs. J Nutr 131:697–700

    Google Scholar 

  10. Jafari SM, Nabipour I, Mahbobnia M et al (1999) Prevalence of iron deficiency in reproductive age in Bushehr province. Iran J Endocrinol Metab 3:209–214

    Google Scholar 

  11. Bhaskaram P (2002) Micronutrient malnutrition, infection, and immunity: an overview. Nutr Rev 60:40–45

    Article  Google Scholar 

  12. Vydyborets’ SV (2000) An analysis of the immunity indices of patients with iron-deficiency anemia. Lik Sprava 3–4:71–75

    PubMed  Google Scholar 

  13. De Silva A, Atukorala S, Weerasinghe I, Ahluwalia N (2003) Iron supplementation improves iron status and reduces morbidity in children with or without upper respiratory tract infections: a randomized controlled study in Colombo, Sri Lanka. Am J Clin Nutr 1:234–241

    Google Scholar 

  14. Liu W, Jiang A, Guo C (1997) Cellular immunity in childhood iron deficiency anemia with recurrent respiratory infections. Zhonghua Xue Ye Xue Za Zhi 18:566–567

    CAS  PubMed  Google Scholar 

  15. Artac H, Coskun M, Karadogan I et al (2007) Transferrin receptor in proliferation of T lymphocytes in infants with iron deficiency. Int J Lab Hematol 29:310–315

    Article  CAS  PubMed  Google Scholar 

  16. Mullick S, Rusia U, Sikka M, Faridi MA (2006) Impact of iron deficiency anaemia on T lymphocytes & their subsets in children. Indian J Med Res 124:647–654

    PubMed  Google Scholar 

  17. Tang YM, Chen XZ, Li GR et al (2006) Effects of iron deficiency anemia on immunity and infectious disease in pregnant women. Wei Sheng Yan Jiu 35:79–81

    PubMed  Google Scholar 

  18. Feng XB, Yang XQ, Shen J (1994) Influence of iron deficiency on serum IgG subclass and pneumococcal polysaccharides specific IgG subclass antibodies. Chin Med J (Engl) 107:813–816

    CAS  Google Scholar 

  19. Ekiz C, Agaoglu L, Karakas Z et al (2005) The effect of iron deficiency anemia on the function of the immune system. Hematol J 5:579–583

    Article  CAS  PubMed  Google Scholar 

  20. Leush SS, Futornyĭ SM (1997) Humoral immunity in women with a normally proceeding pregnancy and in pregnancy complicated by iron-deficiency anemia. Lik Sparva 4:107–110

    Google Scholar 

  21. Abbas AK (2005) Diseases of immunity. In: Kumar V, Abbas AK, Fausto N (eds) Robbins and Cotran pathologic basis of disease, 7th edn. Elsevier Saunders, Pennsylvania, pp 194–196

    Google Scholar 

  22. Gera T, Sachdev HP (2002) Effect of iron supplementation on incidence of infectious illness in children: systematic review. Br Med J 325:1142

    Article  CAS  Google Scholar 

  23. Li Q, Liao Q, Luo C et al (1991) Investigation of impairment of neutrophil’s phagocytosis and bactericidal function in rats with iron deficiency. Hua Xi Yi Ke Da Xue Xue Bao 22:274–277

    CAS  PubMed  Google Scholar 

  24. Guzikowska E, Cholewa Z, Bujniewicź E et al (1989) Various parameters of humoral and cellular immunity in children with iron deficiency. Pol Tyg Lek 44:718–719

    CAS  PubMed  Google Scholar 

  25. Berge J, Schneider D, Dyck JL et al (1992) Iron deficiency, cell mediate immunity and infection among 3–36 month old children living in rural Togo. Nutr Res 12:39–49

    Article  Google Scholar 

  26. Sejas E, Kolsteren P, Hoeree T, Roberfroid D (2008) Iron supplementation in previously anemic Bolivian children normalized hematologic parameters, but not immunologic parameters. J Trop Pediatr 54:164–168

    Article  CAS  PubMed  Google Scholar 

  27. Erickson KL, Medina EA, Hubbard NE (2000) Micronutrients and innate immunity. J Infect Dis 182:5–10

    Article  Google Scholar 

  28. Kurtoglu E, Ugur A, Baltaci AK et al (2003) Activity of neutrophil NADPH oxidase in iron-deficient anemia. Biol Trace Elem Res 96:109–115

    Article  CAS  PubMed  Google Scholar 

  29. Ahluwalia N, Sun J, Krause D et al (2004) Immune function is impaired in iron-deficient, homebound, older women. Am J Clin Nutr 79:516–521

    CAS  PubMed  Google Scholar 

  30. Safuanova GSh, Nikulicheva VI, Bakirov AB (2004) Comprehensive evaluation of the immune system and various cytokines in patients with iron-deficient anemia. Clin Lab Diagn 1:33–35

    Google Scholar 

  31. Kuvibidila S, Warrier RP (2004) Differential effects of iron deficiency and underfeeding on serum levels of interleukin-10, interleukin-12p40, and interferon-gamma in mice. Cytokine 26:73–81

    Article  CAS  PubMed  Google Scholar 

  32. Jason J, Archibald LK, Nwanyanwu OC et al (2001) The effects of iron deficiency on lymphocyte cytokine production and activation: preservation of hepatic iron but not at all cost. Clin Exp Immunol 126:466–473

    Article  CAS  PubMed  Google Scholar 

  33. Kuvibidila SR, Porretta C (2003) Iron deficiency and in vitro iron chelation reduce the expression of cluster of differentiation molecule CD28 but not CD3 receptors on murine thymocytes and spleen cells. Br J Nutr 90:179–189

    Article  CAS  PubMed  Google Scholar 

  34. Brock JH, Mulero V (2000) Cellular and molecular aspects of iron and immune function. Proc Nutr Soc 59:537–540

    CAS  PubMed  Google Scholar 

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Acknowledgments

This study was financially supported by the Research Council of Mashhad University of Medical Sciences. The authors are thankful to them and Mr. Hasan Mansouri Torghabe for his kind assistance in measuring immunoglobulins.

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Mashhad University of Medical Sciences, Iran.

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Authors and Affiliations

  1. Mashhad University of Medical Sciences (MUMS), Mashhad, Iran

    Mohammad Hadi Sadeghian, Mohammad Reza Keramati, Hossein Ayatollahi, Lida Manavifar, Hoda Enaiati & Masoumeh Mahmoudi

  2. Department of Hematopathology, Neonatal Research Center, Imam Reza Hospital, Imam Reza Square, Mashhad, Iran

    Mohammad Reza Keramati

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  1. Mohammad Hadi Sadeghian
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  2. Mohammad Reza Keramati
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  3. Hossein Ayatollahi
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  4. Lida Manavifar
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  6. Masoumeh Mahmoudi
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Correspondence to Mohammad Reza Keramati.

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Sadeghian, M.H., Keramati, M.R., Ayatollahi, H. et al. Serum Immunoglobulins in Patients with Iron Deficiency Anemia. Indian J Hematol Blood Transfus 26, 45–48 (2010). https://doi.org/10.1007/s12288-010-0025-3

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  • DOI: https://doi.org/10.1007/s12288-010-0025-3

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