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Crimean congo hemorrhagic fever infection simulating thrombotic thrombocytopenic purpura

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Abstract

Crimean-Congo hemorrhagic fever (CCHF) is a tick-borne disease that may also be transmitted through person-to-person transmission by exposure to infected body fluids. Despite its wide geographic distribution in animals, CCHF virus is rarely associated with recognized human diseases. We report the first case of CCHF in Kermanshah province, Iran. Clinical presentation was characterized by fever, myalgia, and hemorrhage. The levels of liver enzymes, creatinine phosphokinase, and lactate dehydrogenase were elevated, and bleeding markers were prolonged.

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References

  1. Ergonul O (2006) Crimean-Congo haemorrhagic fever. Lancet Infect Dis 6(4):203–214

    Article  PubMed  Google Scholar 

  2. Whitehouse CA (2004) Crimean-Congo hemorrhagic fever. Antiviral Res 64(3):145–160

    PubMed  CAS  Google Scholar 

  3. Casals J (1969) Antigenic similarity between the virus causing Crimean hemorrhagic fever and Congo virus. Proc Soc Exp Biol Med 131(1):233–236

    PubMed  CAS  Google Scholar 

  4. Gonzalez JP, LeGuenno B, Guillaud M, Wilson ML (1990) A fatal case of Crimean-Congo hemorrhagic fever in Mauritania: virological and serological evidence suggesting epidemic transmission. Trans R Soc Trop Med Hyg 84:573–576

    Article  PubMed  CAS  Google Scholar 

  5. Morrill JC, Soliman AK, Imam IZ, Botros BA, Moussa MI, Watts DM (1990) Serological evidence of Crimean-Congo hemorrhagic fever viral infection among camels imported into Egypt. J Trop Med Hyg 93:201–204

    PubMed  CAS  Google Scholar 

  6. Darvishi M, Ataee B, Chinikar S, Jalali N, Mardani M, Mirkhani M (2005) Seroepidemiology of Crimean-Congo hemorrhagic fever in local and imported sheep in Isfahan Province of Iran. Clin Microbiol Infect 11(suppl 2):649

    Google Scholar 

  7. Casals J (1969) Antigenic similarity between the virus causing Crimean hemorrhagic fever and Congo virus. Proc Soc Exp Biol Med 131:233–236

    PubMed  CAS  Google Scholar 

  8. Whitehouse CA (2004) Crimean-Congo hemorrhagic fever. Antivir Res 64:145–160

    PubMed  CAS  Google Scholar 

  9. Chapman LEML, Wilson DB, Hall et al. (1991) Risk factors for Crimean-Congo hemorrhagic fever in rural northern Senegal. J Infect Dis 164:686–692

    PubMed  CAS  Google Scholar 

  10. Nabeth PD, Cheikh B, Lo O, Faye I, Vall and Niang M (2004) Crimean-Congo hemorrhagic fever, Mauritania. Emerg Infect Dis 10:2143–2149

    PubMed  Google Scholar 

  11. Smego RA, Sarwari AR and Siddiqui AR (2004) Crimean-Congo hemorrhagic fever: prevention and control limitations in a resource-poor country. Clin Infect Dis 38:1731–1735

    Article  PubMed  Google Scholar 

  12. Wilson ML, LeGuenno B, Guillaud M, Desoutter D, Gonzalez JP and Camicas JL (1990) Distribution of Crimean-Congo hemorrhagic fever viral antibody in Senegal: environmental and vectorial correlates. Am J Trop Med Hyg 43:557–566

    PubMed  CAS  Google Scholar 

  13. Burt FJ, Swanepoel R, Shieh WJ et al. (1997) Immuno-histochemical and in situ localization of Crimean-Congo hemorrhagic fever (CCHF) virus in human tissues and implications for CCHF pathogenesis. Arch Pathol Lab Med 121:839–846

    PubMed  CAS  Google Scholar 

  14. Burney MI, Ghafoor A, Saleen M, Webb PA and Casals J (1980) Nosocomial outbreak of viral hemorrhagic fever caused by Crimean hemorrhagic fever-Congo virus in Pakistan, January 1976. Am J Trop Med Hyg 29:941–947

    PubMed  CAS  Google Scholar 

  15. Papa A, Bino S, Llagami A et al. (2002) Crimean-Congo hemorrhagic fever in Albania, 2001. Eur J Clin Microbiol Infect Dis 21:603–606

    Article  PubMed  CAS  Google Scholar 

  16. van Eeden PJ, Joubert JR, van de Wal BW, King JB, de Kock A and Groenewald JH (1985) A nosocomial outbreak of Crimean-Congo haemorrhagic fever at Tygerberg Hospital. Part I. Clinical features. S Afr Med J 68:711–717

    PubMed  Google Scholar 

  17. van Eeden PJ, van Eeden SF, Joubert JR, King JB, van de Wal BW and Michell WL (1985) A nosocomial outbreak of Crimean-Congo haemorrhagic fever at Tygerberg Hospital. Part II. Management of patients. S Afr Med J 68:718–721

    PubMed  Google Scholar 

  18. Mardani M, Jahromi MK, Naieni KH and Zeinali M (2003) The efficacy of oral ribavirin in the treatment of Crimean-Congo hemorrhagic fever in Iran. Clin Infect Dis 36:1613–1618

    Article  PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Kermanshah University of Medical Sciences, Kermanshah, Iran

    Siavash Vaziri, Jafar Navabi, Mandana Afsharian, Babak Sayad, Feizollah Mansouri, Alireza Janbakhsh & Keighobad Ghadiri

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  1. Siavash Vaziri
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  2. Jafar Navabi
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  3. Mandana Afsharian
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  4. Babak Sayad
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  5. Feizollah Mansouri
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  6. Alireza Janbakhsh
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  7. Keighobad Ghadiri
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Correspondence to Siavash Vaziri.

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Vaziri, S., Navabi, J., Afsharian, M. et al. Crimean congo hemorrhagic fever infection simulating thrombotic thrombocytopenic purpura. Indian J Hematol Blood Transfus 24, 35–38 (2008). https://doi.org/10.1007/s12288-008-0022-y

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  • DOI: https://doi.org/10.1007/s12288-008-0022-y

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