Skip to main content

Advertisement

Log in

Prevalence of anxiety among breast cancer patients: a systematic review and meta-analysis

  • Review Article
  • Published:
Breast Cancer Aims and scope Submit manuscript

Abstract

This study aimed to determine the prevalence of anxiety among breast cancer patients. In April 2019, three electronic databases (PubMed, Web of Science, and Scopus) were searched from January, 2000 to March, 2019. Key words included were as follows: breast neoplasm, prevalence, and anxiety. A total of 36 studies that included 16,298 breast cancer patients between 2000 and 2018 were enrolled in the study. The prevalence of anxiety among breast cancer patients was 41.9% [(CI: 95%): 30.7, 53.2]. The prevalence of anxiety among patients in Mediterranean countries was higher. The study showed a high level of anxiety among breast cancer patients, indicating the importance of psychological factors as well as physical in breast cancer patients.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Fig. 1
Fig. 2
Fig. 3
Fig. 4
Fig. 5

Similar content being viewed by others

References

  1. Siegel RL, Miller KD, Jemal A. Cancer statistics, 2019. CA Cancer J Clin. 2019;69(1):7–34.

    Google Scholar 

  2. Bultz BD, Carlson LE. Emotional distress: the sixth vital sign—future directions in cancer care. Psycho-oncology. 2006;15(2):93–5.

    Article  PubMed  Google Scholar 

  3. Caruso R, Nanni MG, Riba MB, Sabato S, Grassi L. The burden of psychosocial morbidity related to cancer: patient and family issues. Int Rev Psychiatry (Abingdon, England). 2017;29(5):389–402.

    Article  Google Scholar 

  4. Hodgkinson K, Butow P, Hunt GE, Pendlebury S, Hobbs KM, Wain G. Breast cancer survivors' supportive care needs 2–10 years after diagnosis. Support Care Cancer. 2007;15(5):515–23.

    Article  PubMed  Google Scholar 

  5. Morasso G, Costantini M, Viterbori P, Bonci F, Del Mastro L, Musso M, et al. Predicting mood disorders in breast cancer patients. Eur J Cancer (Oxford, England: 1990). 2001;37(2):216–23.

  6. Mitchell AJ, Ferguson DW, Gill J, Paul J, Symonds P. Depression and anxiety in long-term cancer survivors compared with spouses and healthy controls: a systematic review and meta-analysis. Lancet Oncol. 2013;14(8):721–32.

    Article  PubMed  Google Scholar 

  7. Forsythe LP, Kent EE, Weaver KE, Buchanan N, Hawkins NA, Rodriguez JL, et al. Receipt of psychosocial care among cancer survivors in the United States. J Clin Oncol. 2013;31(16):1961–9.

    Article  PubMed  PubMed Central  Google Scholar 

  8. World Health Organization. The ICD-10 classification of mental and behavioural disorders: diagnostic criteria for research. Geneva: World Health Organization; 1993.

    Google Scholar 

  9. Association AP. Diagnostic and statistical manual of mental disorders. BMC Med. 2013;17:133–7.

    Google Scholar 

  10. Evans DL, Foa EB, Gur RE, Hendin H, O'Brien CP, Seligman ME, et al. Treating and preventing adolescent mental health disorders: what we know and what we don't know. UK: Oxford University Press; 2005.

    Book  Google Scholar 

  11. Pitman A, Suleman S, Hyde N, Hodgkiss A. Depression and anxiety in patients with cancer. BMJ (Clin Res Ed). 2018;361:k1415.

    Article  Google Scholar 

  12. Stark DPH, House A. Anxiety in cancer patients. Br J Cancer. 2000;83(10):1261.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  13. Hall A, A’hern R, Fallowfield L. Are we using appropriate self-report questionnaires for detecting anxiety and depression in women with early breast cancer? Eur J Cancer. 1999;35(1):79–85.

    Article  CAS  PubMed  Google Scholar 

  14. Trask PC, Esper P, Riba M, Redman B. Psychiatric side effects of interferon therapy: prevalence, proposed mechanisms, and future directions. J Clin Oncol. 2000;18(11):2316–26.

    Article  CAS  PubMed  Google Scholar 

  15. Milligan F, Martinez F, Aal SHMA, Ahmed SA, Joby B, Matalam JS, et al. Assessing anxiety and depression in cancer patients. Br J Nurs. 2018;27(10):S18–S23.

    Article  PubMed  Google Scholar 

  16. Bergerot CD, Laros JA, Araujo TCCFd. Assessment of anxiety and depression in cancer patients: a psychometric comparison. Psico-USF. 2014;19(2):187–97.

    Article  Google Scholar 

  17. Rodgers J, Martin CR, Morse RC, Kendell K, Verrill M. An investigation into the psychometric properties of the Hospital Anxiety and Depression Scale in patients with breast cancer. Health Qual Life Outcomes. 2005;3(1):41.

    Article  PubMed  PubMed Central  Google Scholar 

  18. Schreier AM, Williams SA, editors. Anxiety and quality of life of women who received radiation or chemotherapy for breast cancer. Oncology nursing forum. Pennsylvania: Oncology Nursing Society; 2004.

    Google Scholar 

  19. Aerts P, De Vries J, Van der Steeg A, Roukema J. The relationship between morbidity after axillary surgery and long-term quality of life in breast cancer patients: the role of anxiety. Eur J Surg Oncol (EJSO). 2011;37(4):344–9.

    Article  CAS  PubMed  Google Scholar 

  20. Charalambous A, Kaite CP, Charalambous M, Tistsi T, Kouta C. The effects on anxiety and quality of life of breast cancer patients following completion of the first cycle of chemotherapy. SAGE Open Med. 2017;5:2050312117717507.

    Article  PubMed  PubMed Central  Google Scholar 

  21. Lou Z, Li Y, Yang Y, Wang L, Yang J. Affects of anxiety and depression on health-related quality of life among patients with benign breast lumps diagnosed via ultrasonography in China. Int J Environ Res Public Health. 2015;12(9):10587–601.

    Article  PubMed  PubMed Central  Google Scholar 

  22. Villar RR, Fernandez SP, Garea CC, Pillado MTS, Barreiro VB, Martin CG. Quality of life and anxiety in women with breast cancer before and after treatment. Rev Lat Am Enferm. 2017;25:e2958.

    Article  Google Scholar 

  23. You J, Lu Q, Zvolensky MJ, Meng Z, Garcia K, Cohen L. Anxiety- and health-related quality of life among patients with breast cancer: a cross-cultural comparison of China and the United States. J Glob Oncol. 2018;4:1–9.

    PubMed  Google Scholar 

  24. Akel R, El Darsa H, Anouti B, Mukherji D, Temraz S, Raslan R, et al. Anxiety, depression and quality of life in breast cancer patients in the Levant. Asian Pac J Cancer Prev APJCP. 2017;18(10):2809–16.

    PubMed  Google Scholar 

  25. Kim JH, Paik HJ, Jung YJ, Kim DI, Jo HJ, Lee S, et al. A prospective longitudinal study about change of sleep, anxiety, depression, and quality of life in each step of breast cancer patients. Oncology. 2019;97(4):245–53.

    Article  PubMed  Google Scholar 

  26. Kyranou M, Paul SM, Dunn LB, Puntillo K, Aouizerat BE, Abrams G, et al. Differences in depression, anxiety, and quality of life between women with and without breast pain prior to breast cancer surgery. Eur J Oncol Nurs. 2013;17(2):190–5.

    Article  PubMed  Google Scholar 

  27. Zenger M, Glaesmer H, Hockel M, Hinz A. Pessimism predicts anxiety, depression and quality of life in female cancer patients. Jpn J Clin Oncol. 2011;41(1):87–94.

    Article  PubMed  Google Scholar 

  28. Schreier AM, Williams SA. Anxiety and quality of life of women who receive radiation or chemotherapy for breast cancer. Oncol Nurs Forum. 2004;31(1):127–30.

    Article  PubMed  Google Scholar 

  29. Moher D, Liberati A, Tetzlaff J, Altman DG. Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. Ann Intern Med. 2009;151(4):264–9.

    Article  PubMed  Google Scholar 

  30. WHO. Definition of regional groupings. 2019. https://www.who.int/healthinfo/global_burden_disease/definition_regions/en/. Accessed 30 Mar 2019.

  31. Bank W. How does the World Bank classify countries? 2019. https://databank.worldbank.org/data/source/world-development-indicators. Accessed 30 Mar 2019.

  32. Hoy D, Brooks P, Woolf A, Blyth F, March L, Bain C, et al. Assessing risk of bias in prevalence studies: modification of an existing tool and evidence of interrater agreement. J Clin Epidemiol. 2012;65(9):934–9.

    Article  PubMed  Google Scholar 

  33. Harris J, Cornelius V, Ream E, Cheevers K, Armes J. Anxiety after completion of treatment for early-stage breast cancer: a systematic review to identify candidate predictors and evaluate multivariable model development. Supp Care Cancer. 2017;25(7):2321–33.

    Article  Google Scholar 

  34. Lim CC, Devi MK, Ang E. Anxiety in women with breast cancer undergoing treatment: a systematic review. Int J Evid Based Healthc. 2011;9(3):215–35.

    PubMed  Google Scholar 

  35. Maass SW, Roorda C, Berendsen AJ, Verhaak PF, de Bock GH. The prevalence of long-term symptoms of depression and anxiety after breast cancer treatment: a systematic review. Maturitas. 2015;82(1):100–8.

    Article  CAS  PubMed  Google Scholar 

  36. Stark D, Kiely M, Smith A, Velikova G, House A, Selby P. Anxiety disorders in cancer patients: their nature, associations, and relation to quality of life. J Clin Oncol. 2002;20(14):3137–48.

    Article  CAS  PubMed  Google Scholar 

  37. Tang NK, Lereya ST, Boulton H, Miller MA, Wolke D, Cappuccio FP. Nonpharmacological treatments of insomnia for long-term painful conditions: a systematic review and meta-analysis of patient-reported outcomes in randomized controlled trials. Sleep. 2015;38(11):1751–64.

    Article  PubMed  PubMed Central  Google Scholar 

  38. Vin-Raviv N, Akinyemiju TF, Galea S, Bovbjerg DH. Depression and anxiety disorders among hospitalized women with breast cancer. PLoS ONE. 2015;10(6):e0129169.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  39. Chan CMH, Wan Ahmad WA, Yusof M, Ho GF, Krupat E. Effects of depression and anxiety on mortality in a mixed cancer group: a longitudinal approach using standardised diagnostic interviews. Psycho‐Oncology. 2015;24(6):718–25.

    Article  PubMed  Google Scholar 

  40. Wilson KG, Dalgleish TL, Chochinov HM, Chary S, Gagnon PR, Macmillan K, et al. Mental disorders and the desire for death in patients receiving palliative care for cancer. BMJ Supp Palliat Care. 2016;6(2):170–7.

    Article  Google Scholar 

  41. Mitchell AJ, Chan M, Bhatti H, Halton M, Grassi L, Johansen C, et al. Prevalence of depression, anxiety, and adjustment disorder in oncological, haematological, and palliative-care settings: a meta-analysis of 94 interview-based studies. Lancet Oncol. 2011;12(2):160–74.

    Article  PubMed  Google Scholar 

  42. Baxter AJ, Scott KM, Vos T, Whiteford HA. Global prevalence of anxiety disorders: a systematic review and meta-regression. Psychol Med. 2013;43(5):897–910.

    Article  CAS  PubMed  Google Scholar 

  43. Andersen BL, DeRubeis RJ, Berman BS, Gruman J, Champion VL, Massie MJ, et al. Screening, assessment, and care of anxiety and depressive symptoms in adults with cancer: an American Society of Clinical Oncology guideline adaptation. J Clin Oncol. 2014;32(15):1605.

    Article  PubMed  PubMed Central  Google Scholar 

  44. Butow P, Price MA, Shaw JM, Turner J, Clayton JM, Grimison P, et al. Clinical pathway for the screening, assessment and management of anxiety and depression in adult cancer patients: Australian guidelines. Psycho-Oncology. 2015;24(9):987–1001.

    Article  PubMed  Google Scholar 

  45. Singer S, Das-Munshi J, Brähler E. Prevalence of mental health conditions in cancer patients in acute care—a meta-analysis. Ann Oncol. 2009;21(5):925–30.

    Article  PubMed  Google Scholar 

  46. Watts S, Prescott P, Mason J, McLeod N, Lewith G. Depression and anxiety in ovarian cancer: a systematic review and meta-analysis of prevalence rates. BMJ Open. 2015;5(11):e007618.

    Article  PubMed  PubMed Central  Google Scholar 

  47. Watts S, Leydon G, Birch B, Prescott P, Lai L, Eardley S, et al. Depression and anxiety in prostate cancer: a systematic review and meta-analysis of prevalence rates. BMJ Open. 2014;4(3):e003901.

    Article  PubMed  PubMed Central  Google Scholar 

  48. Akinyemiju TF. Socio-economic and health access determinants of breast and cervical cancer screening in low-income countries: analysis of the World Health Survey. PLoS ONE. 2012;7(11):e48834.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  49. Coughlin SS, Ekwueme DU. Breast cancer as a global health concern. Cancer Epidemiol. 2009;33(5):315–8.

    Article  PubMed  Google Scholar 

  50. Gutnik LA, Matanje-Mwagomba B, Msosa V, Mzumara S, Khondowe B, Moses A, et al. Breast cancer screening in low- and middle-income countries: a perspective from Malawi. J Glob Oncol. 2015;2(1):4–8.

    Article  PubMed  PubMed Central  Google Scholar 

  51. Ricardo-Rodrigues I, Jimenez-Garcia R, Hernandez-Barrera V, Carrasco-Garrido P, Jimenez-Trujillo I, Lopez de Andres A. Social disparities in access to breast and cervical cancer screening by women living in Spain. Public Health. 2015;129(7):881–8.

    Article  CAS  PubMed  Google Scholar 

  52. Yip CH, Smith RA, Anderson BO, Miller AB, Thomas DB, Ang ES, et al. Guideline implementation for breast healthcare in low- and middle-income countries: early detection resource allocation. Cancer. 2008;113(8 Suppl):2244–56.

    Article  PubMed  Google Scholar 

  53. Lueboonthavatchai P. Prevalence and psychosocial factors of anxiety and depression in breast cancer patients. J Med Assoc Thail. 2007;90(10):2164.

    Google Scholar 

  54. Montgomery GH, David D, Goldfarb AB, Silverstein JH, Weltz CR, Birk JS, et al. Sources of anticipatory distress among breast surgery patients. J Behav Med. 2003;26(2):153–64.

    Article  PubMed  Google Scholar 

  55. Colton CW, Manderscheid RW. Congruencies in increased mortality rates, years of potential life lost, and causes of death among public mental health clients in eight states. Prev Chronic Dis. 2006;3(2):A42.

    PubMed  PubMed Central  Google Scholar 

  56. Mausbach BT, Bos T, Irwin SA. Mental health treatment dose and annual healthcare costs in patients with cancer and major depressive disorder. Health Psychol. 2018;37(11):1035–40.

    Article  PubMed  PubMed Central  Google Scholar 

  57. Walker ER, McGee RE, Druss BG. Mortality in mental disorders and global disease burden implications: a systematic review and meta-analysis. JAMA Psychiatry. 2015;72(4):334–41.

    Article  PubMed  PubMed Central  Google Scholar 

  58. Krebber A, Buffart L, Kleijn G, Riepma I, De Bree R, Leemans C, et al. Prevalence of depression in cancer patients: a meta-analysis of diagnostic interviews and self-report instruments. Psycho-Oncology. 2014;23(2):121–30.

    Article  CAS  PubMed  Google Scholar 

  59. Mukherjee A, Mazumder K, Ghoshal S. Impact of different sociodemographic factors on mental health status of female cancer patients receiving chemotherapy for recurrent disease. Indian J Palliat Care. 2018;24(4):426.

    Article  PubMed  PubMed Central  Google Scholar 

  60. Anuk D, Özkan M, Kizir A, Özkan S. The characteristics and risk factors for common psychiatric disorders in patients with cancer seeking help for mental health. BMC Psychiatry. 2019;19(1):269.

    Article  PubMed  PubMed Central  Google Scholar 

  61. Beatty L, Kissane D, editors. Anxiety and depression in women with breast cancer. Cancer forum. Sydney: The Cancer Council Australia; 2017.

    Google Scholar 

  62. Vahdaninia M, Omidvari S, Montazeri A. What do predict anxiety and depression in breast cancer patients? A follow-up study. Soc Psychiatry Psychiatr Epidemiol. 2010;45(3):355–61.

    Article  PubMed  Google Scholar 

  63. Burgess C, Cornelius V, Love S, Graham J, Richards M, Ramirez A. Depression and anxiety in women with early breast cancer: five year observational cohort study. BMJ (Clin Res Ed). 2005;330(7493):702.

    Article  Google Scholar 

  64. Ahmed AE, Albalawi AN, Qureshey ET, Qureshey AT, Yenugadhati N, Al-Jahdali H, et al. Psychological symptoms in adult Saudi Arabian cancer patients: prevalence and association with self-rated oral health. Breast Cancer (Dove Medical Press). 2018;10:153–9.

    PubMed  PubMed Central  Google Scholar 

  65. Alacacioglu A, Yavuzsen T, Dirioz M, Yilmaz U. Quality of life, anxiety and depression in Turkish breast cancer patients and in their husbands. Med Oncol (Northwood, London, England). 2009;26(4):415–9.

    Article  Google Scholar 

  66. Alacacioglu A, Ulger E, Varol U, Yildiz I, Salman T, Bayoglu V, et al. Depression, anxiety and sexual satisfaction in breast cancer patients and their partners-Izmir oncology group study. Asian Pac J Cancer Prev APJCP. 2014;15(24):10631–6.

    Article  PubMed  Google Scholar 

  67. Al-Zaben FN, Sehlo MG, Koenig HG. A cross-sectional study of anxiety and marital quality among women with breast cancer at a university clinic in western Saudi Arabia. Saudi Med J. 2015;36(10):1168–75.

    Article  PubMed  PubMed Central  Google Scholar 

  68. Fafouti M, Paparrigopoulos T, Zervas Y, Rabavilas A, Malamos N, Liappas I, et al. Depression, anxiety and general psychopathology in breast cancer patients: a cross-sectional control study. Vivo (Athens, Greece). 2010;24(5):803–10.

    CAS  PubMed  Google Scholar 

  69. Fatiregun OA, Olagunju AT, Erinfolami AR, Arogunmati OA, Fatiregun OA, Adeyemi JD. Relationship between anxiety disorders and domains of health related quality of life among Nigerians with breast cancer. Breast. 2017;31:150–6.

    Article  PubMed  Google Scholar 

  70. Galloway SK, Baker M, Giglio P, Chin S, Madan A, Malcolm R, et al. Depression and anxiety symptoms relate to distinct components of pain experience among patients with breast cancer. Pain Res Treat. 2012;2012:851276.

    PubMed  PubMed Central  Google Scholar 

  71. Geyikci R, Cakmak S, Demirkol ME, Uguz S. Correlation of anxiety and depression levels with attitudes towards coping with illness and sociodemographic characteristics in patients with a diagnosis of breast cancer. Dusunen Adam J Psychiatry Neurol Sci. 2018;31(3):246–57.

    Article  Google Scholar 

  72. Guimond AJ, Massicotte E, Savard MH, Charron-Drolet J, Ruel S, Ivers H, et al. Is anxiety associated with hot flashes in women with breast cancer? Menopause. 2015;22(8):864–71.

    Article  PubMed  Google Scholar 

  73. Hartl K, Schennach R, Muller M, Engel J, Reinecker H, Sommer H, et al. Quality of life, anxiety, and oncological factors: a follow-up study of breast cancer patients. Psychosomatics. 2010;51(2):112–23.

    Article  PubMed  Google Scholar 

  74. Hassan MR, Shah SA, Ghazi HF, Mohd Mujar NM, Samsuri MF, Baharom N. Anxiety and depression among breast cancer patients in an urban setting in Malaysia. Asian Pac J Cancer Prev APJCP. 2015;16(9):4031–5.

    Article  PubMed  Google Scholar 

  75. Hill J, Holcombe C, Clark L, Boothby MRK, Hincks A, Fisher J, et al. Predictors of onset of depression and anxiety in the year after diagnosis of breast cancer. Psychol Med. 2011;41(7):1429–36.

    Article  CAS  PubMed  Google Scholar 

  76. Ho SS, So WK, Leung DY, Lai ET, Chan CW. Anxiety, depression and quality of life in Chinese women with breast cancer during and after treatment: a comparative evaluation. Eur J Oncol Nurs. 2013;17(6):877–82.

    Article  PubMed  Google Scholar 

  77. Hopwood P, Sumo G, Mills J, Haviland J, Bliss JM. The course of anxiety and depression over 5 years of follow-up and risk factors in women with early breast cancer: results from the UK Standardisation of Radiotherapy Trials (START). Breast. 2010;19(2):84–91.

    Article  PubMed  Google Scholar 

  78. Jimenez-Fonseca P, Calderon C, Hernandez R, Cajal TRY, Mut M, Ramchandani A, et al. Factors associated with anxiety and depression in cancer patients prior to initiating adjuvant therapy. Clin Transl Oncol. 2018;20(11):1408–15.

    Article  CAS  PubMed  Google Scholar 

  79. Kalender M, Buyukhatipoglu H, Balakan O, Suner A, Dirier A, Sevinc A, et al. Depression, anxiety and quality of life through the use of complementary and alternative medicine among breast cancer patients in Turkey. J Cancer Res Ther. 2014;10(4):962–6.

    Article  PubMed  Google Scholar 

  80. Karakoyun-Celik O, Gorken I, Sahin S, Orcin E, Alanyali H, Kinay M. Depression and anxiety levels in woman under follow-up for breast cancer: relationship to coping with cancer and quality of life. Med Oncol (Northwood, London, England). 2010;27(1):108–13.

    Article  Google Scholar 

  81. Lewis F, Merckaert I, Lienard A, Libert Y, Etienne AM, Reynaert C, et al. Anxiety and its time courses during radiotherapy for non-metastatic breast cancer: a longitudinal study. Radiother Oncol. 2014;111(2):276–80.

    Article  PubMed  Google Scholar 

  82. Linden W, Vodermaier A, MacKenzie R, Greig D. Anxiety and depression after cancer diagnosis: Prevalence rates by cancer type, gender, and age. J Affect Disord. 2012;141(2–3):343–51.

    Article  PubMed  Google Scholar 

  83. Lueboonthavatchai P. Prevalence and psychosocial factors of anxiety and depression in breast cancer patients. J Med Assoc Thail (Chotmaihet Thangphaet). 2007;90(10):2164–74.

  84. Montazeri A, Jarvandi S, Haghighat S, Vahdani M, Sajadian A, Ebrahimi M, et al. Anxiety and depression in breast cancer patients before and after participation in a cancer support group. Patient Educ Couns. 2001;45(3):195–8.

    Article  CAS  PubMed  Google Scholar 

  85. Montazeri A, Harirchi I, Vahdani M, Khaleghi F, Jarvandi S, Ebrahimi M, et al. Anxiety and depression in Iranian breast cancer patients before and after diagnosis. Eur J Cancer Care. 2000;9(3):151–7.

    Article  CAS  Google Scholar 

  86. Montazeri A, Sajadian A, Ebrahimi M, Akbari ME. Depression and the use of complementary medicine among breast cancer patients. Supp Care Cancer. 2005;13(5):339–42.

    Article  Google Scholar 

  87. Ng GC, Mohamed S, Sulaiman AH, Zainal NZ. Anxiety and depression in cancer patients: the association with religiosity and religious coping. J Relig Health. 2017;56(2):575–90.

    Article  PubMed  Google Scholar 

  88. Park EM, Gelber S, Rosenberg SM, Seah DSE, Schapira L, Come SE, et al. Anxiety and depression in young women with metastatic breast cancer: a cross-sectional study. Psychosomatics. 2018;59(3):251–8.

    Article  PubMed  PubMed Central  Google Scholar 

  89. Puigpinos-Riera R, Graells-Sans A, Serral G, Continente X, Bargallo X, Domenech M, et al. Anxiety and depression in women with breast cancer: social and clinical determinants and influence of the social network and social support (DAMA cohort). Cancer Epidemiol. 2018;55:123–9.

    Article  CAS  PubMed  Google Scholar 

  90. Reece JC, Chan YF, Herbert J, Gralow J, Fann JR. Course of depression, mental health service utilization and treatment preferences in women receiving chemotherapy for breast cancer. Gen Hosp Psychiatry. 2013;35(4):376–81.

    Article  PubMed  Google Scholar 

  91. Saboonchi F, Petersson LM, Wennman-Larsen A, Alexanderson K, Brannstrom R, Vaez M. Changes in caseness of anxiety and depression in breast cancer patients during the first year following surgery: patterns of transiency and severity of the distress response. Eur J Oncol Nurs. 2014;18(6):598–604.

    Article  PubMed  Google Scholar 

  92. Schleife H, Sachtleben C, Finck Barboza C, Singer S, Hinz A. Anxiety, depression, and quality of life in German ambulatory breast cancer patients. Breast Cancer. 2014;21(2):208–13.

    Article  PubMed  Google Scholar 

  93. Sharma A, Zhang JP. Depression and its predictors among breast cancer patients in Nepal. ASEAN J Psychiatry. 2015;16(1):106–15.

    Google Scholar 

  94. So WK, Marsh G, Ling WM, Leung FY, Lo JC, Yeung M, et al. Anxiety, depression and quality of life among Chinese breast cancer patients during adjuvant therapy. Eur J Oncol Nurs. 2010;14(1):17–22.

    Article  PubMed  Google Scholar 

  95. Tsaras K, Papathanasiou IV, Mitsi D, Veneti A, Kelesi M, Zyga S, et al. Assessment of depression and anxiety in breast cancer patients: prevalence and associated factors. Asian Pac J Cancer Prev APJCP. 2018;19(6):1661–9.

    PubMed  Google Scholar 

  96. Zhang J, Zhou Y, Feng Z, Xu Y, Zeng G. Longitudinal trends in anxiety, depression, and quality of life during different intermittent periods of adjuvant breast cancer chemotherapy. Cancer Nurs. 2018;41(1):62–8.

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Mahin Badakhsh.

Ethics declarations

Conflict of interest

All authors declare that they have no competing of interest.

Ethical approval

This article does not contain any studies with human participants or animals performed by any of the authors.

Informed consent

As this study was a systematic review and did not involve contact with patients or patient information, informed consent is not applicable.

Research involving human participants and/or animals

This article does not contain any studies with human participants or animals performed by any of the authors.

Additional information

Publisher's Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Hashemi, SM., Rafiemanesh, H., Aghamohammadi, T. et al. Prevalence of anxiety among breast cancer patients: a systematic review and meta-analysis. Breast Cancer 27, 166–178 (2020). https://doi.org/10.1007/s12282-019-01031-9

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s12282-019-01031-9

Keywords

Navigation