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Oncoplastic approach to excisional breast biopsies: a randomized controlled, phase 2a trial

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Abstract

Background

Oncoplastic surgery has been used in breast cancer patients for better cosmetic outcome over the last decades. The aim of this prospective randomized study is to show its place in excisional breast biopsy.

Methods

An oncoplastic approach excision was compared with conventional excisional breast biopsies. The study included 80 patients, of whom half received oncoplastic intervention and half received the conventional. The primary endpoint was the cosmetic result. Patient, surgeon and independent observers rated the results on a four-point scale. Scores other than self-perceived were based on third-month medical photographs.

Results

Between May 20, 2015 and April 27, 2016, 40 patients were randomly assigned to oncoplastic biopsy and 40 patients were assigned to conventional excisional biopsy. Median follow-up was 5.6 months (IQR 3.0–6.0). Self-perceived perfect scoring for general cosmetic outcome was found significantly higher after oncoplastic biopsy (73 0.5%) comparing with control group (32.4%) (p = 0.001). This impact did not change after adjusting patients for potential confounders. Margin clearance rates in malignant cases were comparable in both arms (p = 0.999); four patients in oncoplastic biopsy group (40%) and three patients in control group (33%) had positive margins.

Conclusions

The oncoplastic biopsy achieved better cosmetic results with similar surgical margin positivity rates when compared with conventional breast biopsy. It may be a better biopsy option used for patients requiring excisional breast biopsy.

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Acknowledgements

We gratefully acknowledge the contributions of Anesthesiology and Pathology Department staff at Akdeniz University Hospital and Serkan Sayılıkan Plastic and reconstructive surgeon who was invited to attend as an independent professional observer for the esthetic evaluations.

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Authors and Affiliations

  1. Department of General Surgery, Palandöken State Hospital, Erzurum, Turkey

    Volkan Doğru

  2. Department of General Surgery, Akdeniz University Hospital, Antalya, Turkey

    Muhittin Yaprak, Ayhan Mesci & Cumhur Arıcı

  3. Department of Radiology, Akdeniz University Hospital, Antalya, Turkey

    Emel Durmaz

  4. Department of Plastic and Reconstructive Surgery, Akdeniz University Hospital, Antalya, Turkey

    Özlenen Özkan & Ömer Özkan

  5. Department of General Surgery, Istanbul School of Medicine, Istanbul University, Istanbul, Turkey

    Vahit Özmen

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  1. Volkan Doğru
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  2. Muhittin Yaprak
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Correspondence to Volkan Doğru.

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Doğru, V., Yaprak, M., Durmaz, E. et al. Oncoplastic approach to excisional breast biopsies: a randomized controlled, phase 2a trial. Breast Cancer 26, 84–92 (2019). https://doi.org/10.1007/s12282-018-0892-2

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  • DOI: https://doi.org/10.1007/s12282-018-0892-2

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