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Ductal adenoma of breast: imaging characteristics and radiologic–pathologic correlation of unique findings which reflect “pseudoinvasion”

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Abstract

Purpose

To investigate the imaging characteristics of rare ductal adenoma of the breast, we evaluated the detailed imaging findings and correlated them with the pathologic features of the ductal adenomas. In particular, we describe in detail the imaging findings derived from “pseudoinvasion,” one of the histological features unique to this tumor.

Materials and methods

We reviewed the imaging findings including magnetic resonance imaging (MRI) in three patients with ductal adenomas of the breast and correlated the findings with the detailed histological features.

Results

All patients exhibited well-demarcated nodules with smooth margins on mammography. On ultrasonography, two patients exhibited mural nodules within cysts. The bases of mural nodules protruded into the mammary glands. On contrast-enhanced MRI, these margins were smooth. Histologically, the bases showed foci of tumor cells scattered into collagenous materials (pseudoinvasion), the tumor foci were located along the collagen fibers; therefore, the margins were smooth.

Conclusions

Distinguishing ductal adenoma from invasive carcinoma is an urgent issue. A clear margin of ‘pseudoinvasion’ on MRI is both a unique finding and a useful diagnostic clue.

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Conflict of interest

The authors declare that they have no conflict of interest.

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Authors and Affiliations

  1. Breast Care Center, Department of Radiology and Clinical Research Institute, National Kyushu Medical Center, 1-8-1, Jigyohama, Chuo-ku, Fukuoka, 810-8563, Japan

    Roka Namoto Matsubayashi

  2. Department of Radiology and Clinical Research Institute, National Kyushu Medical Center, Fukuoka, Japan

    Toru Muranaka

  3. Department of Pathology and Clinical Research Institute, National Kyushu Medical Center, Fukuoka, Japan

    Seiya Momosaki

Authors
  1. Roka Namoto Matsubayashi
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  2. Seiya Momosaki
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  3. Toru Muranaka
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Correspondence to Roka Namoto Matsubayashi.

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Matsubayashi, R.N., Momosaki, S. & Muranaka, T. Ductal adenoma of breast: imaging characteristics and radiologic–pathologic correlation of unique findings which reflect “pseudoinvasion”. Breast Cancer 23, 597–606 (2016). https://doi.org/10.1007/s12282-015-0608-9

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  • DOI: https://doi.org/10.1007/s12282-015-0608-9

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