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Tumor lysis syndrome following trastuzumab for breast cancer: a case report and review of the literature

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Abstract

Tumor lysis syndrome, a complication of anticancer chemotherapy, results from rapid lysis of malignant cells. We report tumor lysis syndrome in a patient treated with trastuzumab for metastatic breast carcinoma. A 69-year-old woman was diagnosed with multiple liver metastases 1 month after mastectomy. As her liver functions had deteriorated, chemotherapeutic agents were contraindicated and she was treated with trastuzumab alone. On day 6 of the first course of trastuzumab, she developed tumor lysis syndrome. As her liver functions showed deterioration due to multiple hepatic metastases, hemodialysis was contraindicated. Acute renal failure worsened and she died 11 days after the administration of trastuzumab.

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References

  1. Gemici C. Tumour lysis syndrome in solid tumours. Clin Oncol. 2006;18(10):773–80.

    Article  CAS  Google Scholar 

  2. Bertrand C, Arnold A, Ching-Hon P, et al. Guidelines for the management of pediatric and adult tumor lysis syndrome: an evidence-based review. J Clin Oncol. 2008;26(16):2767–78.

    Article  Google Scholar 

  3. Mott FE, Esana A, Chakmakjian C, et al. Tumor lysis syndrome in solid tumors. Support Cancer Ther. 2005;2(3):188–91.

    Article  PubMed  Google Scholar 

  4. Beriwal S, Singh S, Garcia-Young JA. Tumor lysis syndrome in extensive-stage small-cell lung cancer. Am J Clin Oncol. 2002;25(5):474–5.

    Article  PubMed  Google Scholar 

  5. Kallab AM, Jillella AP. Tumor lysis syndrome in small cell lung cancer. Med Oncol. 2001;18(2):149–51.

    Article  CAS  PubMed  Google Scholar 

  6. Kalemkerian GP, Darwish B, Varterasian ML. Tumor lysis syndrome in small cell carcinoma and other solid tumors. Am J Med. 1997;103(5):363–7.

    Article  CAS  PubMed  Google Scholar 

  7. Kurt M, Onal IK, Elkiran T, et al. Acute tumor lysis syndrome triggered by zoledronic acid in a patient with metastatic lung adenocarcinoma. Med Oncol. 2005;22(2):203–6.

    Article  PubMed  Google Scholar 

  8. Feld J, Mehta H, Burkes RL. Acute spontaneous tumor lysis syndrome in adenocarcinoma of the lung: a case report. Am J Clin Oncol. 2000;23(5):491–3.

    Article  CAS  PubMed  Google Scholar 

  9. Sewani HH, Rabatin JT. Acute tumor lysis syndrome in a patient with mixed small cell and non-small cell tumor. Mayo Clin Proc. 2002;77(7):722–8.

    Article  PubMed  Google Scholar 

  10. Hsieh PM, Hung KC, Chen YS. Tumor lysis syndrome after transarterial chemoembolization of hepatocellular carcinoma: case reports and literature review. World J Gastroenterol. 2009;15(37):4726–8.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  11. Shiba H, Ishida Y, Wakiyama S, et al. Acute tumor lysis syndrome after transarterial chemoembolization for hepatocellular carcinoma. Cancer Sci. 2008;99(10):2104–5.

    Article  CAS  PubMed  Google Scholar 

  12. Vaisban E, Braester A, Mosenzon O, et al. Spontaneous tumor lysis syndrome in solid tumors: really a rare condition? Am J Med Sci. 2003;325(1):38–40.

    Article  PubMed  Google Scholar 

  13. Shiozawa K, Watanabe M, Takenaka H, et al. Tumor lysis syndrome after sorafenib for hepatocellular carcinoma: a case report. Hepatogastroenterology. 2010;57(101):688–90.

    CAS  PubMed  Google Scholar 

  14. Zigrossi P, Brustia M, Bobbio F, et al. Flare and tumor lysis syndrome with atypical features after letrozole therapy in advanced breast cancer. A case report. Ann Ital Med Int. 2001;16(2):112–7.

    CAS  PubMed  Google Scholar 

  15. Rostom AY, El-Hussainy G, Kandil A, et al. Tumor lysis syndrome following hemi-body irradiation for metastatic breast cancer. Ann Oncol. 2000;11(10):1349–51.

    Article  CAS  PubMed  Google Scholar 

  16. Sklarin NT, Markham M. Spontaneous recurrent tumor lysis syndrome in breast cancer. Am J Clin Oncol. 1995;18(1):71–3.

    Article  CAS  PubMed  Google Scholar 

  17. Lin CJ, Lim KH, Cheng YC, et al. Tumor lysis syndrome after treatment with gemcitabine for metastatic transitional cell carcinoma. Med Oncol. 2007;24(4):455–7.

    Article  CAS  PubMed  Google Scholar 

  18. Michels J, Lassau N, Gross-Goupil M, et al. Sunitinib inducing tumor lysis syndrome in a patient treated for renal carcinoma. Invest New Drugs. 2010;28(5):690–3.

    Article  PubMed  Google Scholar 

  19. Wright JL, Lin DW, Dewan P, et al. Tumor lysis syndrome in a patient with metastatic, androgen independent prostate cancer. Int J Urol. 2005;12(11):1012–3.

    Article  PubMed  Google Scholar 

  20. Nakamura Y, Nakamura Y, Hori E, et al. Tumor lysis syndrome after transcatheter arterial infusion of cisplatin and embolization therapy for liver metastases of melanoma. Int J Dermatol. 2009;48(7):763–7.

    Article  PubMed  Google Scholar 

  21. Habib GS, Saliba WR. Tumor lysis syndrome after hydrocortisone treatment in metastatic melanoma: a case report and review of the literature. Am J Med Sci. 2002;323(3):155–7.

    Article  PubMed  Google Scholar 

  22. Castro MP, VanAuken J, Spencer-Cisek P, et al. Acute tumor lysis syndrome associated with concurrent biochemotherapy of metastatic melanoma: a case report and review of the literature. Cancer. 1999;85(5):1055–9.

    Article  CAS  PubMed  Google Scholar 

  23. Oztop I, Demirkan B, Yaren A, et al. Rapid tumor lysis syndrome in a patient with metastatic colon cancer as a complication of treatment with 5-fluorouracil/leucoverin and irinotecan. Tumori. 2004;90(5):514–6.

    PubMed  Google Scholar 

  24. Woo IS, Kim JS, Park MJ, et al. Spontaneous acute tumor lysis syndrome with advanced gastric cancer. J Korean Med Sci. 2001;16(1):115–8.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  25. Gold JE, Malamud SC, LaRosa F, et al. Adoptive chemoimmunotherapy using ex vivo activated memory T-cells and cyclophosphamide: tumor lysis syndrome of a metastatic soft tissue sarcoma. Am J Hematol. 1993;44(1):42–7.

    Article  CAS  PubMed  Google Scholar 

  26. Pinder EM, Atwal GS, Ayantunde AA, et al. Tumour lysis syndrome occurring in a patient with metastatic gastrointestinal stromal tumour treated with Glivec (imatinib mesylate, Gleevec, STI571). Sarcoma. 2007;2007:82012.

    Article  PubMed Central  PubMed  Google Scholar 

  27. Hiraizumi Y, Kamoi S, Inde Y, et al. A case of tumor lysis syndrome following chemotherapy for a uterine epithelioid leiomyosarcoma with focal rhabdomyosarcomatous differentiation. J Obstet Gynaecol Res. 2011;37(7):947–52.

    Article  PubMed  Google Scholar 

  28. Bilgrami SF, Fallon BG. Tumor lysis syndrome after combination chemotherapy for ovarian cancer. Med Pediatr Oncol. 1993;21(7):521–4.

    Article  CAS  PubMed  Google Scholar 

  29. Schuman S, Pearson JM, Lucci JA 3rd, et al. Metastatic gestational trophoblastic neoplasia complicated by tumor lysis syndrome, heart failure, and thyrotoxicosis: a case report. J Reprod Med. 2010;55(9–10):441–4.

    PubMed  Google Scholar 

  30. Baeksgaard L, Sørensen JB. Acute tumor lysis syndrome in solid tumors—a case report and review of the literature. Cancer Chemother Pharmacol. 2003;51(3):187–92.

    CAS  PubMed  Google Scholar 

  31. D’Alessandro V, Greco A, Clemente C, et al. Severe spontaneous acute tumor lysis syndrome and hypoglycemia in patient with germ cell tumor. Tumori. 2010;96(6):1040–3.

    PubMed  Google Scholar 

  32. Qian KQ, Ye H, Xiao YW, et al. Tumor lysis syndrome associated with chemotherapy in primary retroperitoneal soft tissue sarcoma by ex vivo ATP-based tumor chemo-sensitivity assay (ATP-TCA). Int J Gen Med. 2009;2:1–4.

    PubMed Central  CAS  PubMed  Google Scholar 

  33. Abboud M, Shamseddine A. Maxillary sinus squamous cell carcinoma presenting with fatal tumor lysis syndrome: a case report and review of the literature. Case Rep Oncol. 2009;2(3):229–33.

    Article  PubMed Central  PubMed  Google Scholar 

  34. Yokoi K, Miyazawa N, Kano Y, et al. Tumor lysis syndrome in invasive thymoma with peripheral blood T-cell lymphocytosis. Am J Clin Oncol. 1997;20(1):86–9.

    Article  CAS  PubMed  Google Scholar 

  35. Froilán Torres C, Castro Carbajo P, Pajares Villarroya R, et al. Acute spontaneous tumor lysis syndrome in a patient with Crohn’s disease taking immunosuppressants. Rev Esp Enferm Dig. 2009;101(4):288–94.

    Article  PubMed  Google Scholar 

  36. Kurt M, Eren OO, Engin H, et al. Tumor lysis syndrome following a single dose of capecitabine. Ann Pharmacother. 2004;38(5):902.

    Article  PubMed  Google Scholar 

  37. Ustündağ Y, Boyacioğlu S, Haznedaroğlu IC, et al. Acute tumor lysis syndrome associated with paclitaxel. Ann Pharmacother. 1997;31(12):1548–9.

    PubMed  Google Scholar 

  38. Drakos P, Bar-Ziv J, Catane R. Tumor lysis syndrome in nonhematologic malignancies. Report of a case and review of the literature. Am J Clin Oncol. 1994;17(6):502–5.

    Article  CAS  PubMed  Google Scholar 

  39. Barton JC. Tumor lysis syndrome in nonhematopoietic neoplasms. Cancer. 1989;64(3):738–40.

    Article  CAS  PubMed  Google Scholar 

  40. Stark ME, Dyer MC, Coonley CJ. Fatal acute tumor lysis syndrome with metastatic breast carcinoma. Cancer. 1987;60(4):762–4.

    Article  CAS  PubMed  Google Scholar 

  41. Cech P, Block JB, Cone LA. Tumor lysis syndrome after tamoxifen flare. N Engl J Med. 1986;315(4):263–4.

    Article  CAS  PubMed  Google Scholar 

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Acknowledgments

We thank the patient, her family, and the personnel involved in the treatment of this case.

Conflict of interest

None.

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Authors and Affiliations

  1. Department of Breast Oncology, Juntendo University Hospital, 2-1-1 Hongo, Bunkyo-ku, Tokyo, 113-8421, Japan

    Fumi Taira, Yoshiya Horimoto & Mitsue Saito

Authors
  1. Fumi Taira
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  2. Yoshiya Horimoto
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  3. Mitsue Saito
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Corresponding author

Correspondence to Fumi Taira.

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Taira, F., Horimoto, Y. & Saito, M. Tumor lysis syndrome following trastuzumab for breast cancer: a case report and review of the literature. Breast Cancer 22, 664–668 (2015). https://doi.org/10.1007/s12282-013-0448-4

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  • DOI: https://doi.org/10.1007/s12282-013-0448-4

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