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Photoacoustic mammography: initial clinical results

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Abstract

Purpose

Photoacoustic tomography can image the hemoglobin distribution and oxygenation state inside tissue with high spatial resolution. The purpose of this study is to investigate its clinical usefulness for diagnosis of breast cancer and evaluation of therapeutic response in relation to other diagnostic modalities.

Materials and methods

Using a prototype machine for photoacoustic mammography (PAM), 27 breast tumor lesions, including 21 invasive breast cancer (IBC), five ductal carcinoma in situ (DCIS), and one phyllodes tumor, were measured. Nine out of twenty-one IBC patients had received primary systemic therapy (PST).

Results

Eight out of twelve IBC without PST were visible. Notably, detection was possible in all five cases with DCIS, whereas it was not in one case with phyllodes tumor. Seven out of nine IBC with PST were assigned as visible in spite of decreased size of tumor after PST. The mean value of hemoglobin saturation in the visible lesions was 78.6 %, and hemoglobin concentration was 207 μM. The tumor images of PAM were comparable to those of magnetic resonance imaging (MRI).

Conclusions

It is suggested that PAM can image tumor vascularity and oxygenation, which may be useful for diagnosis and characterization of breast cancer.

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Acknowledgments

This work is partly supported by the Innovative Techno-Hub for Integrated Medical Bio-imaging Project of the Special Coordination Funds for Promoting Science and Technology, from the Ministry of Education, Culture, Sports, Science, and Technology, Japan.

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Authors and Affiliations

  1. Department of Breast Surgery, Graduate School of Medicine, Kyoto University, 54 Kawaracho Shogoin Sakyoku, Kyoto, 6068507, Japan

    Toshiyuki Kitai, Masae Torii, Tomoharu Sugie & Masakazu Toi

  2. Department of Diagnostic Imaging and Nuclear Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan

    Shotaro Kanao

  3. Department of Diagnostic Pathology, Graduate School of Medicine, Kyoto University, Kyoto, Japan

    Yoshiki Mikami

  4. Department of Human Health Science, Graduate School of Medicine, Kyoto University, Kyoto, Japan

    Tsuyoshi Shiina

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  1. Toshiyuki Kitai
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  2. Masae Torii
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  3. Tomoharu Sugie
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  5. Yoshiki Mikami
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Correspondence to Toshiyuki Kitai.

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Kitai, T., Torii, M., Sugie, T. et al. Photoacoustic mammography: initial clinical results. Breast Cancer 21, 146–153 (2014). https://doi.org/10.1007/s12282-012-0363-0

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  • DOI: https://doi.org/10.1007/s12282-012-0363-0

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