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Association between the −402GA, −401GT, and −323ins10-bp polymorphisms of factor VII gene and breast cancer

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Abstract

Background and Purpose

Recent data have shown that the hemostatic system may play a role in cancer development and progression. To test whether factor VII (FVII) can be a candidate factor for breast cancer, we have evaluated the distribution of FVII gene polymorphisms in breast cancer patients and healthy subjects.

Methods

The nested case–control study consisted of 92 women with breast cancer (group 1) and 80 control subjects (in age-matched women) (group 2). Genotyping of the −323ins10-bp, −401GT, and −402GA polymorphisms of the FVII gene was performed by the method of single-strand conformation polymorphism analysis and sequencing.

Results

A significant difference was observed in the distribution of the −402GA genotype and allele frequencies in breast cancer and control cases (p < 0.05). For other polymorphisms of the FVII gene, the distributions of genotypes and allele frequencies were not significantly different between two groups (p > 0.05). There was also a significant difference between the distributions of the haplotypes in breast cancer patients and control subjects (p < 0.05).

Conclusion

Although the number of cases in this study was small, the preliminary findings revealed a possible contribution of the FVII −402GA polymorphism in the development of breast cancer. However, further case–control studies with larger series are needed to confirm our findings.

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Authors and Affiliations

  1. Department of General Surgery, Ankara University Medical School, Ankara, Turkey

    Aydan Eroğlu

  2. Department of Pediatric Molecular Genetic, Ankara University Medical School, Ankara, Turkey

    Ayşenur Öztürk & Nejat Akar

Authors
  1. Aydan Eroğlu
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  2. Ayşenur Öztürk
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  3. Nejat Akar
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Correspondence to Aydan Eroğlu.

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Eroğlu, A., Öztürk, A. & Akar, N. Association between the −402GA, −401GT, and −323ins10-bp polymorphisms of factor VII gene and breast cancer. Breast Cancer 18, 282–285 (2011). https://doi.org/10.1007/s12282-009-0189-6

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  • DOI: https://doi.org/10.1007/s12282-009-0189-6

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