Abstract
Background
Radiofrequency ablation (RFA) is an emerging minimally invasive technique for breast cancer treatment. There are two different needle designs. One is to deploy a series of arrays to allow an even distribution of heat within the tumor. A new design is a straight needle with continuous infusion of cold saline to prevent charring and ensure continuous heat delivery. We report the first comparative study using two different needles for ablation of breast cancer.
Methods
Chinese patients with breast cancer less than 2 cm were prospectively recruited. Multifocal tumor was excluded. RFA was performed under general anesthesia following sentinel node biopsy. Sequential allocation was used. In the first group, tumor was ablated by using the LeVeen needle. Cool-tip needle was used in the subsequent group. The tumor was then resected. Tumor viability was assessed by nicotinamide adenine dinucleotide-diaphorase (NADH) staining. Complete ablation rate was compared. Evidence of thermal damage to the skin was also assessed.
Results
Twenty patients were recruited. Mean tumor size was 14 mm. Complete ablation rate was the same (90% versus 89% for the Cool-tip and the LeVeen, respectively). Cool-tip has a shorter ablation time when compared with LeVeen (12 versus 28 min), and the Cool-tip needle was found to be easier to insert. There was no visible skin burn after RFA.
Conclusions
Cool-tip and LeVeen systems had the same efficacy in ablation of breast cancer, but Cool-tip was easier to insert and had a shorter ablation time.
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Acknowledgments
The authors would like to thank Dr. Chi Kin Chung for his inspiration given on this work. The authors would like to acknowledge the generous support from Tung Wah Group of Hospitals’ Research Fund, Boston Scientific Hong Kong and Covidien Hong Kong.
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Hung, W.K., Mak, K.L., Ying, M. et al. Radiofrequency ablation of breast cancer: a comparative study of two needle designs. Breast Cancer 18, 124–128 (2011). https://doi.org/10.1007/s12282-009-0181-1
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DOI: https://doi.org/10.1007/s12282-009-0181-1