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Molecular prediction of the therapeutic response to neoadjuvant chemotherapy in breast cancer

  • Conference Paper
  • Presidential symposium: Individualized diagnosis for tailored treatment of breast cancer
  • Published:
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Abstract

Breast cancer is considered to be relatively sensitive to chemotherapy, and multiple combinations of cytotoxic agents are used as standard therapy. Chemotherapy is applied empirically despite the observation that not all regimens are equally effective across the population of patients. Up to date clinical tests for predicting cancer chemotherapy response are not available, and individual markers have shown little predictive value. A number of microarray studies have demonstrated the use of genomic data, particularly gene expression signatures, as clinical prognostic factors in breast cancer. The identification of patient subpopulations most likely to respond to therapy is a central goal of recent personalized medicine. We have designed experiments to identify gene sets that will predict treatment-specific response in breast cancer. Taken together with our recent trial about the construction of a high-throughput functional screening system for chemo-sensitivity related genes, studies for drug sensitivity will provide rational strategies for establishment of the prediction system with high accuracy, and identification of ideal targets for drug intervention.

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Authors and Affiliations

  1. Genome Center, Cancer Institute (Japanese Foundation for Cancer Research), 3-10-6 Ariake, Koto-ku, Tokyo, 135-8550, Japan

    Koichi Nagasaki & Yoshio Miki

  2. Department of Molecular Genetics, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan

    Yoshio Miki

Authors
  1. Koichi Nagasaki
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  2. Yoshio Miki
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Corresponding author

Correspondence to Koichi Nagasaki.

Additional information

This article is based on a presentation delivered at Presidential Symposium 1, “Breast cancer: individualized diagnosis for tailored treatment,” held on 29 June 2007 at the 15th Annual Meeting of the Japanese Breast Cancer Society in Yokohama.

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Nagasaki, K., Miki, Y. Molecular prediction of the therapeutic response to neoadjuvant chemotherapy in breast cancer. Breast Cancer 15, 117–120 (2008). https://doi.org/10.1007/s12282-008-0031-6

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  • DOI: https://doi.org/10.1007/s12282-008-0031-6

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