Skip to main content

Advertisement

SpringerLink
Log in

Rare and emerging agents of hyalohyphomycosis

  • Published:
Current Fungal Infection Reports Aims and scope Submit manuscript

Abstract

The list of opportunistic agents of hyalohyphomycosis continues to grow, as does the number of immunocompromised patients; however, these mycoses also are manifested in patients who appear immunocompetent by current methods of detection. Although fungi causing hyalohyphomycosis span the Kingdom Fungi, the majority are found within the asexual or mitosporic fungi, with notable exceptions. The following is a discussion of recent, selected literature citations regarding hyaline fungi that are both “new” agents of disease, as well as “new” species within well-known taxonomic groups.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References and Recommended Reading

  1. Nucci M, Anaissie E: Emerging fungi. Infect Dis Clin North Am 2006, 20:563–579.

    Article  PubMed  Google Scholar 

  2. Verweij PE, Brandt ME: Aspergillus, Fusarium, and other opportunistic moniliaceous fungi. In Manual of Clinical Microbiology, edn 9. Edited by Murray PR, Baron EJ, Jorgensen JH, et al. Washington, DC: ASM Press; 2007:1802–1838.

    Google Scholar 

  3. Ajello L: Hyalohyphomycosis and phaeohyphomycosis: two global disease entities of public health importance. Eur J Epidemiol 1986, 2:243–251.

    Article  PubMed  CAS  Google Scholar 

  4. Samson RA, Hong SB, Frisvad JC: Old and new concepts of species differentiation in Aspergillus. Med Mycol 2006, 44:S133–S148.

    Article  CAS  Google Scholar 

  5. Balajee SA, Sigler L, Brandt ME: DNA and the classical way: identification of medically important molds in the 21st century. Med Mycol 2007, 45:475–490.

    Article  PubMed  CAS  Google Scholar 

  6. Geiser DM, Klich MA, Frisvad JC, et al.: The current status of species recognition and identification in Aspergillus. Stud Mycol 2007, 59:1–10.

    Article  PubMed  CAS  Google Scholar 

  7. Balajee SA, Houbraken J, Verweij PE, et al.: Aspergillus species identification in the clinical setting. Stud Mycol 2007, 59:39–46.

    PubMed  CAS  Google Scholar 

  8. Balajee SA, Gribskow JL, Hanley E, et al.: Aspergillus lentulus sp. nov., a new sibling species of A. fumigatus. Eukaryot Cell 2005, 5:625–632.

    Article  CAS  Google Scholar 

  9. Alcazar-Fuoli L, Mellado E, Alastruey-Izquierdo A, et al.: Aspergillus section Fumigati: antifungal susceptibility patterns and sequence-based identification. Antimicrob Agents Chemother 2008, 52:1244–1251.

    Article  PubMed  CAS  Google Scholar 

  10. Hong SB, Go SJ, Shin HD, et al.: Polyphasic taxonomy of Aspergillus fumigatus and related species. Mycologia 2005, 97:1316–1329.

    Article  PubMed  CAS  Google Scholar 

  11. Balajee SA, Lindsley MD, Iqbal N, et al.: Nonsporulating clinical isolates identified as Petromyces alliaceus (anamorph Aspergillus alleaceus) by morphological and sequence-based methods. J Clin Microbiol 2007, 45:2701–2703.

    Article  PubMed  CAS  Google Scholar 

  12. Kredics L, Varga J, Kocsube S, et al.: Case of keratitis caused by Aspergillus tamari. J Clin Microbiol 2007, 45:3464–3467.

    Article  PubMed  Google Scholar 

  13. Panackal AA, Imhog A, Hanley EW, Marr KA: Aspergillus ustus infections among transplant recipients. Emerg Infect Dis 2006, 3:403–408.

    Google Scholar 

  14. Saracli MA, Mutlu FM, Yildiran ST, et al.: Clustering of invasive Aspergillus ustus eye infections in a tertiary care hospital: a molecular epidemiologic study of an uncommon species. Med Mycol 2007, 45:377–384.

    Article  PubMed  CAS  Google Scholar 

  15. Varga J, Houbraken J, van der Lee HA, et al.: Aspergillus calidoustus sp. nov., causative agents of human infections previously assigned to A. ustus. Eukaryot Cell 2008, 7:630–638.

    Article  PubMed  CAS  Google Scholar 

  16. O’Donnell K, Sutton DA, Rinaldi MG, et al.: Genetic diversity of human pathogenic members of the Fusarium oxysporum complex inferred from multilocus DNA sequence data and amplified fragment length polymorphism analyses: evidence for the recent dispersion of a geographically widespread clonal lineage and nosocomial origin. J Clin Microbiol 2004, 42:5109–5120.

    Article  PubMed  CAS  Google Scholar 

  17. Rao SK, Lam PTH, Li EYM, et al.: A case series of contact lens-associated Fusarium keratitis in Hong Kong. Cornea 2007, 26:1205–1209.

    Article  PubMed  Google Scholar 

  18. Khor WB, Aung T, Saw SM, et al.: An outbreak of Fusarium keratitis associated with contact lens wear in Singapore. JAMA 2006, 295:2867–2873.

    Article  PubMed  CAS  Google Scholar 

  19. O’Donnell K, Sarver BAJ, Brandt M, et al.: Phylogenetic diversity and microsphere array-based genotyping of human pathogenic fusaria, including isolates from the multistate contact lens-associated U.S. keratitis outbreaks of 2005 and 2006. J Clin Microbiol 2007, 45:2235–2248.

    Article  PubMed  CAS  Google Scholar 

  20. Imamura Y, Chandra J, Mukherjee PK, et al.: Fusarium and Candida albicans biofilms on soft contact lenses: model development, influence of lens type, and susceptibility to lens care solutions. Antimicrob Agents Chemother 2008, 52:171–182.

    Article  PubMed  CAS  Google Scholar 

  21. Kaliamurthy J, Jesudasan C, Prasanth DA, Thomas PA: Keratitis due to Cylindrocarpon lichenicola. J Postgrad Med 2006, 52:155–157.

    PubMed  CAS  Google Scholar 

  22. Kaben U, Beck R, Tintelnot K: Keratomycosis due to Cylindrocarpon lichenicola. Mycoses 2006, 49(Suppl 2):9–13.

    Article  PubMed  Google Scholar 

  23. Summerbell RC, Schroers HJ: Analysis of phylogenetic relationship of Cylindrocarpon lichenicola and Acremonium falciforme to the Fusarium solani species complex and a review of similarities in the spectrum of opportunistic infections caused by these fungi. J Clin Microbiol 2002, 40:2866–2875.

    Article  PubMed  CAS  Google Scholar 

  24. Taj-Aldeen SJ, Gene J, Al Bozom I, et al.: Gangrenous necrosis of the diabetic foot caused by Fusarium acutatum. Med Mycol 2006, 44:547–552.

    Article  PubMed  Google Scholar 

  25. Guarro J, Rubio C, Gené J, et al.: Case of keratitis caused by an uncommon Fusarium species. J Clin Microbiol 2003, 41:5823–5826.

    Article  PubMed  Google Scholar 

  26. Cortez KJ, Roilides E, Quiroz-Telles F, et al.: Infections caused by Scedosporium spp. Clin Microbiol Rev 2008, 21:157–197.

    Article  PubMed  CAS  Google Scholar 

  27. Gilgado F, Cano J, Gené J, Guarro J: Molecular phylogeny of the Pseudallescheria boydii species complex: proposal of two new species. J Clin Microbiol 2005, 43:4930–4942.

    Article  PubMed  CAS  Google Scholar 

  28. Zeng JS, Fukushima K, Takizawa K, et al.: Intraspecific diversity of species of the Pseudallescheria bodyii complex. Med Mycol 2007, 45:547–558.

    Article  PubMed  CAS  Google Scholar 

  29. Delhaes L, Harum A, Chem SCA, et al.: Molecular typing of Australian Scedosporium isolates showing genetic variability and numerous S. aurantiacum. Emerg Infect Dis 2008, 14:282–290.

    Article  PubMed  CAS  Google Scholar 

  30. Alastruey-Izquierdo A, Cuenca-Estrella M, Monzón A, Rodríguez-Tudela JL: Prevalence and susceptibility testing of a new species of Pseudallescheria and Scedosporium in a collection of clinical mold isolates. Antimicrob Agents Chemother 2007, 51:748–751.

    Article  PubMed  CAS  Google Scholar 

  31. Gilgado F, Cano J, Gené J, et al.: Molecular and phenotypic data supporting distinct species statuses for Scedosporium apiospermum and Pseudallescheria boydii and the proposed new species Scedosporium dehoogii. J Clin Microbiol 2008, 46:766–771.

    Article  PubMed  Google Scholar 

  32. Horré R, Gilges S, Breig P, et al.: Case report. Fungaemia due to Penicillium piceum, a member of the Penicillium marneffei complex. Mycoses 2001, 44:502–504.

    Article  PubMed  Google Scholar 

  33. Santos PE, Piontelli E, Shea YR, et al.: Penicillium piceum infection: diagnosis and successful treatment in chronic granulomatous disease. Med Mycol 2006, 44:749–753.

    Article  PubMed  CAS  Google Scholar 

  34. van Schooneveld T, Freifeld A, Lesiak B, et al.: Paecilomyces lilacinus infection in a liver transplant patient: case report and review of the literature. Transplant Infect Dis 2008, 10:117–122.

    Article  Google Scholar 

  35. Lott ME, Sheehan DJ, Davis LS: Paecilomyces lilacinus infection with a sporotrichoid pattern in a renal transplant patient. J Drugs Dermatol 2007, 6:436–439.

    PubMed  Google Scholar 

  36. Miyakis S, Velegraki A, Delikou S, et al.: Invasive Acremonium strictum infection in a bone marrow transplant recipient. Pediatr Infect Dis J 2006, 25:273–275.

    Article  PubMed  Google Scholar 

  37. Foell JL, Fischer M, Seibold, et al.: Lethal double infection with Acremonium strictum and Aspergillus fumigatus during induction chemotherapy in a child with ALL. Pediatr Blood Cancer 2007, 49:858–861.

    Article  PubMed  CAS  Google Scholar 

  38. Kuhls K, Lieckfeldt E, Börner T, Guého E: Molecular reidentification of human pathogenic Trichoderma isolates as Trichoderma longibrachiatum and Trichoderma citrinoviride. Med Mycol 1999, 37:25–33.

    PubMed  CAS  Google Scholar 

  39. Osorio S, de la Cámara R, Monteserin MC, et al.: Recurrent disseminated skin lesions due to Metarrhizium anisopliae in an adult patient with acute myelogenous leukemia. J Clin Microbiol 2007, 45:651–655.

    Article  PubMed  CAS  Google Scholar 

  40. Tu E, Park A: Recalcitrant Beauveria bassiana keratitis: confocal microscopy findings and treatment with posaconazole (Noxafil). Cornea 2007, 26:1008–1010.

    Article  PubMed  Google Scholar 

  41. Tucker DL, Beresford CH, Sigler L, Rogers K: Disseminated Beauveria bassiana infection in a patient with acute lymphoblastic leukemia. J Clin Microbiol 2004, 42:5412–5414.

    Article  PubMed  CAS  Google Scholar 

  42. Wuyts WA, Molzahn H, Maertens J, et al.: Fatal Scopulariopsis infection in a lung transplant recipient: a case report. J Heart Lung Transplant 2005, 24:2301–2304.

    Article  PubMed  Google Scholar 

  43. Cano J, Guarro J, Gené J: Molecular and morphological identification of Colletotrichum species of clinical interest. J Clin Microbiol 2004, 42:2450–2454.

    Article  PubMed  Google Scholar 

  44. Balajee SA, Gribskov J, Brandt M, et al.: Mistaken identity: Neosartorya pseudofischeri and its anamorph masquerading as Aspergillus fumigatus. J Clin Microbiol 2005, 43:5996–5999.

    Article  PubMed  CAS  Google Scholar 

  45. Suh MK, Lim JW, Lee YH, et al.: Subcutaneous hyalohyphomycosis due to Cephalotheca foveolata in an immunocompetent host. Br J Dermatol 2006, 154:1184–1189.

    Article  PubMed  CAS  Google Scholar 

  46. Manikandan P, Vismer HF, Kredics L, et al.: Corneal ulcer due to Neocosmospora vasinfecta in an immunocompetent patient. Med Mycol 2008, 46:279–384.

    Article  PubMed  CAS  Google Scholar 

  47. Yaguchi T, Sano A, Yarita K, et al.: A new species of Cephalotheca isolated from a Korean patient. Mycotaxon 2006, 96:309–322.

    Google Scholar 

  48. Sutton DA, Thompson EH, Rinaldi MG, et al.: Identification and first report of Inonotus (Phellinus) tropicalis as an etiologic agent in a patient with chronic granulomatous disease. J Clin Microbiol 2005, 43:982–987.

    Article  PubMed  CAS  Google Scholar 

  49. Davis CM, Noroski LM, Dishop MK, et al.: Basidiomycetous fungal Inonotus tropicalis sacral osteomyelitis in X-linked chronic granulomatous disease. Pediatr Infect Dis J 2007, 26:655–656.

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Fungus Testing Laboratory, Department of Pathology, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX, 78229-3900, USA

    Deanna A. Sutton

Authors
  1. Deanna A. Sutton
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Deanna A. Sutton.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Sutton, D.A. Rare and emerging agents of hyalohyphomycosis. Curr Fungal Infect Rep 2, 134–142 (2008). https://doi.org/10.1007/s12281-008-0020-4

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s12281-008-0020-4

Keywords

Search

Navigation