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The contribution of Aspergillus fumigatus stress responses to virulence and antifungal resistance

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  • Biology of Human Fungal Pathogen
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Abstract

Invasive aspergillosis has emerged as one of the most common life-threatening fungal disease of humans. The emergence of antifungal resistant pathogens represents a current and increasing threat to society. In turn, new strategies to combat fungal infection are urgently required. Fungal adaptations to stresses experienced within the human host are a prerequisite for the survival and virulence strategies of the pathogen. Here, we review the latest information on the signalling pathways in Aspergillus fumigatus that contribute to stress adaptations and virulence, while highlighting their potential as targets for the development of novel combinational antifungal therapies.

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Authors and Affiliations

  1. Plant Biology and Crop Science, Rothamsted Research, Harpenden, Hertfordshire, UK

    Neil A. Brown

  2. Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo, São Paulo, Brasil

    Gustavo H. Goldman

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  1. Neil A. Brown
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  2. Gustavo H. Goldman
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Correspondence to Neil A. Brown or Gustavo H. Goldman.

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Brown, N.A., Goldman, G.H. The contribution of Aspergillus fumigatus stress responses to virulence and antifungal resistance. J Microbiol. 54, 243–253 (2016). https://doi.org/10.1007/s12275-016-5510-4

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  • DOI: https://doi.org/10.1007/s12275-016-5510-4

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