Abstract
Since 2003, highly pathogenic avian influenza (HPAI) virus outbreaks have occurred five times in Korea, with four HPAI H5N1 outbreaks and one HPAI H5N8 outbreak. Migratory birds have been suggested to be the first source of HPAI in Korea. Here, we surveyed migratory wild birds for the presence of AI and compared regional AI prevalence in wild birds from September 2012 to April 2014 for birds having migratory pathways in South Korea. Finally, we investigated the prevalence of AI in migratory birds before and after HPAI H5N8 outbreaks. Overall, we captured 1617 migratory wild birds, while 18,817 feces samples and 74 dead birds were collected from major wild bird habitats. A total of 21 HPAI viruses were isolated from dead birds, and 86 low pathogenic AI (LPAI) viruses were isolated from captured birds and from feces samples. Spatiotemporal distribution analysis revealed that AI viruses were spread southward until December, but tended to shift north after January, consistent with the movement of migratory birds in South Korea. Furthermore, we found that LPAI virus prevalences within wild birds were notably higher in 2013–2014 than the previous prevalence during the northward migration season. The data from our study demonstrate the importance of the surveillance of AI in wild birds. Future studies including in-depth genetic analysis in combination with evaluation of the movement and ecology of migratory birds might help us to bridge the gaps in our knowledge and better explain, predict, and ultimately prevent future HPAI outbreaks.
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Allan W.H., Lancaster J.E., and Tóth B. 1978. Newcastle disease vaccines, their production and use. FAO Animal Production and Health series, issue 10, Food and Agriculture Organization, United Nations.
Chen H., Li Y., Li Z., Shi J., Shinya K., Deng G., Qi Q., Tian G., Fan S., Zhao H., et al. 2006. Properties and dissemination of H5N1 viruses isolated during an influenza outbreak in migratory waterfowl in western China. J. Virol. 80, 5976–5983.
Chen H., Smith G.J., Zhang S.Y., Qin K., Wang J., Li K.S., Webster R.G., Peiris J.S., and Guan Y. 2005. Avian flu: H5N1 virus outbreak in migratory waterfowl. Nature 436, 191–192.
Fouchier R.A., Bestebroer T.M., Herfst S., Van Der Kemp L., Rimmelzwaan G.F., and Osterhaus A.D. 2000. Detection of influenza A viruses from different species by PCR amplification of conserved sequences in the matrix gene. J. Clin. Microbiol. 38, 4096–4101.
Fouchier R.A., Schneeberger P.M., Rozendaal F.W., Broekman J.M., Kemink S.A., Munster V., Kuiken T., Rimmelzwaan G.F., Schutten M., van Doornum G.J., et al. 2004. Avian influenza Avirus (H7N7) associated with human conjunctivitis and a fatal case of acute respiratory distress syndrome. Proc. Natl. Acad. Sci. USA 101, 1356–1361.
Gall A., Hoffmann B., Harder T., Grund C., and Beer M. 2008. Universal primer set for amplification and sequencing of HA0 cleavage sites of all influenza A viruses. J. Clin. Microbiol. 46, 2561–2567.
Gilbert M., Jambal L., Karesh W.B., Fine A., Shiilegdamba E., Dulam P., Sodnomdarjaa R., Ganzorig K., Batchuluun D., Tseveenmyadag N., et al. 2012. Highly pathogenic avian influenza virus among wild birds in Mongolia. PLoS One 7, e44097.
Hoffmann E., Stech J., Guan Y., Webster R.G., and Perez D.R. 2001. Universal primer set for the full-length amplification of all influenza A viruses. Arch. Virol. 146, 2275–2289.
Jeong J., Kang H.M., Lee E.K., Song B.M., Kwon Y.K., Kim H.R., Choi K.S., Kim J.Y., Lee H.J., Moon O.K., et al. 2014. Highly pathogenic avian influenza virus (H5N8) in domestic poultry and its relationship with migratory birds in South Korea during 2014. Vet. Microbiol. 173, 249–257.
Kilpatrick A.M., Chmura A.A., Gibbons D.W., Fleischer R.C., Marra P.P., and Daszak P. 2006. Predicting the global spread of H5N1 avian influenza. Proc. Natl. Acad. Sci. USA 103, 19368–19373.
Kim H.R., Kim B.S., Bae Y.C., Moon O.K., Oem J.K., Kang H.M., Choi J.G., Lee O.S., and Lee Y.J. 2011. H5N1 subtype highly pathogenic avian influenza virus isolated from healthy mallard captured in South Korea. Vet. Microbiol. 151, 386–389.
Kim H.R., Lee Y.J., Park C.K., Oem J.K., Lee O.S., Kang H.M., Choi J.G., and Bae Y.C. 2012. Highly pathogenic avian influenza (H5N1) outbreaks in wild birds and poultry, South Korea. Emerg. Infect. Dis. 18, 480–483.
Kim Y.I., Pascua P.N.Q., Kwon H.I., Lim G.J., Kim E.H., Yoon S.W., Park S.J., Kim S.M., Choi E.J., Si Y.J., et al. 2014. Pathobiological features of a novel, highly pathogenic avian influenza A (H5N8) virus. Emerg. Microbes Infect. 3, e75.
Kwon Y.K., Joh S.J., Kim M.C., Lee Y.J., Choi J.G., Lee E.K., Wee S.H., Sung H.W., Kwon J.H., Kang M.I., et al. 2005. Highly pathogenic avian influenza in magpies (Pica pica sericea) in South Korea. J. Wildl. Dis. 41, 618–623.
Lee M.S., Chang P.C., Shien J.H., Cheng M.C., and Shieh H.K. 2001. Identification and subtyping of avian influenza viruses by reverse transcription-PCR. J. Virol. Methods 97, 13–22.
Lee Y.J., Choi Y.K., Kim Y.J., Song M.S., Jeong O.M., Lee E.K., Jeon W.J., Jeong W., Joh S.J., Choi K.S., et al. 2008. Highly pathogenic avian influenza virus (H5N1) in domestic poultry and relationship with migratory birds, South Korea. Emerg. Infect. Dis. 14, 487–490.
Liu J., Xiao H., Lei F., Zhu Q., Qin K., Zhang X.W., Zhang X.L., Zhao D., Wang G., Feng Y., et al. 2005. Highly pathogenic H5N1 influenza virus infection in migratory birds. Science 309, 1206.
Marinova-Petkova A., Feeroz M.M., Alam S.M.R, Hasan M.K., Akhtar S., Jones-Engel L., Walker D., McClenaghan L., Rubrum A., Franks J., et al. 2014. Multiple introductions of highly pathogenic avian influenza H5N1 viruses into Bangladesh. Emerg. Microbes Infect. 3, e11.
Monne I., Fusaro A., Nelson M.I., Bonfanti L., Mulatti P., Hughes J., Murcia P.R., Schivo A., Valastro V., Moreno A., et al. 2014. Emergence of a highly pathogenic avian influenza virus from a low-pathogenic progenitor. J. Virol. 88, 4375–4388.
Monne I., Hussein H.A., Fusaro A., Valastro V., Hamoud M.M., Khalefa R.A., Dardir S.N., Radwan M.I., Capua I., and Cattoli G. 2013a. H9N2 influenza A virus circulates in H5N1 endemically infected poultry population in Egypt. Influenza Other Respir. Viruses 7, 240–243.
Monne I., Yamage M., Dauphin G., Claes F., Ahmed G., Giasuddin M., Salviato A., Ormelli S., Bonfante F., Schivo A., et al. 2013b. Reassortant avian influenza A (H5N1) viruses with H9N2-PB1 gene in poultry, Bangladesh. Emerg. Infect. Dis. 19, 1630–1634.
Sidoti F., Rizzo F., Costa C., Astegiano S., Curtoni A., Mandola M.L., Cavallo R., and Bergallo M. 2010. Development of real time RT-PCR assays for detection of type A influenza virus and for subtyping of avian H5 and H7 hemagglutinin subtypes. Mol. Biotechnol. 44, 41–50.
Stallknecht D.E. and Shane S.M. 1988. Host range of avian influenza virus in free-living birds. Vet. Res. Commun. 12, 125–141.
Subbarao K., Klimov A., Katz J., Regnery H., Lim W., Hall H., Perdue M., Swayne D., Bender C., Huang J., et al. 1998. Characterization of an avian influenza A (H5N1) virus isolated from a child with a fatal respiratory illness. Science 279, 393–396.
Takekawa J., Heath S.R., Douglas D.C., Perry W.M., Javed S., Newman S.H., Suwal R.N., Rahmani A.R., Choudhury B.C., Prosser D.J., et al. 2013. Geographic variation in Bar-headed geese Anser indicus: connectivity of wintering areas and breeding grounds across a broad front. Wildfowl 59, 100–123.
Webster R.G., Bean W.J., Gorman O.T., Chambers T.M., and Kawaoka Y. 1992. Evolution and ecology of influenza A viruses. Microbiol. Rev. 56, 152–179.
Whitworth D., Newman S., Mundkur T., and Harris P. 2007. Wild birds and avian influenza: an introduction to applied field research and disease sampling techniques. FAO Animal Production and Health Manual No. 5, Food and Agriculture Organization, United Nations.
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Shin, JH., Woo, C., Wang, SJ. et al. Prevalence of avian influenza virus in wild birds before and after the HPAI H5N8 outbreak in 2014 in South Korea. J Microbiol. 53, 475–480 (2015). https://doi.org/10.1007/s12275-015-5224-z
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DOI: https://doi.org/10.1007/s12275-015-5224-z