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Varilactones and wortmannilactones produced by Penicillium variabile cultured with histone deacetylase inhibitor

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A Correction to this article was published on 26 November 2018

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Abstract

Seven polyketides, including four new ones named as varilactones A–B (1–2) and wortmannilactones M–N (3–4), as well as three biogenetically related known wortmannilactones E, F and H (5–7), were isolated from the fungus Penicillium variabile HXQ-H-1, cultivated in potato-based medium with the histone deacetylase inhibitor suberoylanilide hydroxamic acid (SAHA). Their structures (1–7) were established by analysis of NMR and MS data, and the absolute configuration of oxabicyclo[2.2.1]heptane unit was deduced from 1H-NMR analyses on MPA esters after chemical reduction reaction. Among them, varilactones A and B (1 and 2), features a novel skeleton with a triene unit linking an oxabicyclo[2.2.1]heptane and an oxabicyclo[3.3.0]octane rings.

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Change history

  • 26 November 2018

    The author would like to include conflict of interest statement of the online published article. The correct conflict of interest statement should read as.

  • 26 November 2018

    The author would like to include conflict of interest statement of the online published article. The correct conflict of interest statement should read as.

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Acknowledgements

This work was financially supported by the National Natural Science Foundation of China (21372208), the Shandong Provincial Natural Science Fund for Distinguished Young Scholars (JQ201422), AoShan Talents Program Supported by Qingdao National Laboratory for Marine Science and Technology (2015ASTP-ES09), NSFC-Shandong Joint Fund for Marine Science Research Centers (U1606403), Shandong province key research and development program (2016GSF201204), and Fundamental Research Funds for the Central Universities (201564026).

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  1. Xueqian He and Zhenzhen Zhang contributed equally.

Authors and Affiliations

  1. Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao, 266003, People’s Republic of China

    Xueqian He, Zhenzhen Zhang, Qian Che, Tianjiao Zhu, Qianqun Gu & Dehai Li

  2. Laboratory for Marine Drugs and Bioproducts of Qingdao National Laboratory for Marine Science and Technology, Qingdao, 266237, People’s Republic of China

    Dehai Li

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  1. Xueqian He
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  2. Zhenzhen Zhang
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Correspondence to Dehai Li.

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He, X., Zhang, Z., Che, Q. et al. Varilactones and wortmannilactones produced by Penicillium variabile cultured with histone deacetylase inhibitor. Arch. Pharm. Res. 41, 57–63 (2018). https://doi.org/10.1007/s12272-017-0982-2

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