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Chemical constituents from Belamcanda chinensis and their inhibitory effects on nitric oxide production in RAW 264.7 macrophage cells

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Abstract

Belamcanda chinensis (L.) DC., which belongs to the family of Iridaceae, has been used as a folk medicine for the treatment of inflammation, asthma, tonsillitis, and many other throat disorders. Bioactivity-guided purification of the methylene chloride-soluble fraction of the rhizomes of B. chinensis based on the inhibition of nitric oxide production led to the identification of seventeen known compounds. Their structures were elucidated on the basis of extensive spectroscopic measurement such as NMR and ESI–MS. All of the isolated compounds were evaluated for their inhibitory effects on nitric oxide production in LPS-induced RAW 264.7 macrophage cells.

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Acknowledgments

This research was supported financially by the Medical Research Center Program (MRC, 2008-0062275) through the National Research Foundation of Korea. The authors thank the Center for Research Instruments and Experimental Facilities, Chungbuk National University for providing the NMR spectroscopic measurements.

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Authors and Affiliations

  1. College of Pharmacy, Chungbuk National University, Cheongju, 362-763, Korea

    Jin Woo Lee, Chul Lee, Qinghao Jin, Youngsoo Kim, Jin Tae Hong, Mi Kyeong Lee & Bang Yeon Hwang

  2. Eco-friendly Material Research Center, Korea Research Institute of Bioscience and Biotechnology, Jeonbuk, 580-185, Korea

    Chul Lee

  3. College of Agriculture, Life and Environmental Sciences, Chungbuk National University, Cheongju, 362-763, Korea

    Moon-Soon Lee

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  1. Jin Woo Lee
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  2. Chul Lee
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  3. Qinghao Jin
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  4. Moon-Soon Lee
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Correspondence to Bang Yeon Hwang.

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Lee, J.W., Lee, C., Jin, Q. et al. Chemical constituents from Belamcanda chinensis and their inhibitory effects on nitric oxide production in RAW 264.7 macrophage cells. Arch. Pharm. Res. 38, 991–997 (2015). https://doi.org/10.1007/s12272-014-0529-8

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  • DOI: https://doi.org/10.1007/s12272-014-0529-8

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