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Five new sesquiterpene lactones from Inula hupehensis

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Abstract

Four new pseudoguaianolides (1–4), one new guaianolide (5), together with ten known compounds (6–15) were isolated from the aerial parts of Inula hupehensis. Their structures were elucidated mainly on the basis of 1D and 2D spectroscopic methods and circular dichroism analysis. In addition, compounds 1–10 and 13 were tested for their inhibitory effects against LPS-induced NO production in RAW264.7 macrophages. Compounds 2, 6, 8 and 9 exhibited significant inhibitory activities with IC50 values in the range of 0.6–6.6 μM.

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Acknowledgments

The work was supported by program NCET Foundation, NSFC (81230090 and 81102778), partially supported by Global Research Network for Medicinal Plants (GRNMP) and King Saud University, Shanghai Leading Academic Discipline Project (B906), FP7-PEOPLE-IRSES-2008 (TCMCANCER Project 230232), Key laboratory of drug research for special environments, PLA, Shanghai Engineering Research Center for the Preparation of Bioactive Natural Products (10DZ2251300) and the Scientific Foundation of Shanghai China (10DZ1971700, 12401900501). National Major Project of China (2011ZX09307-002-03). National Key Technology R&D Program of China (2012BAI29B06).

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Authors and Affiliations

  1. School of Pharmacy, Shanghai Jiao Tong University, Shanghai Dongchuan Rd 800, Shanghai, 200240, China

    Jie Ren, Jiang Jiang Qin, Xiang Rong Cheng, Shi Kai Yan, Hui Zi Jin & Wei Dong Zhang

  2. Department of Phytochemistry, Second Military Medical University, Shanghai, 200433, China

    Wei Dong Zhang

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  1. Jie Ren
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  2. Jiang Jiang Qin
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  3. Xiang Rong Cheng
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  4. Shi Kai Yan
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  5. Hui Zi Jin
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Correspondence to Hui Zi Jin or Wei Dong Zhang.

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Ren, J., Qin, J.J., Cheng, X.R. et al. Five new sesquiterpene lactones from Inula hupehensis . Arch. Pharm. Res. 36, 1319–1325 (2013). https://doi.org/10.1007/s12272-013-0135-1

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