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Clauraila E from the roots of Clausena harmandiana and antifungal activity against Pythium insidiosum

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Abstract

A new carbazole alkaloid named clauraila E (1) together with 8 known compounds were isolated from the methanol extract of the roots of Clausena harmandiana. All compounds were evaluated for antifungal activity against Pythium insidiosum using disc diffusion assay. Pythium insidiosum is a fungus-like microorganism, for which antifungals available now are not effective. It was found that compounds 3, 6, 7 and 9 could inhibit the mycelia growth of P. insidiosum. The results show convincingly that they may be lead to compounds for the development of probiotic or novel antifungal drugs.

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Acknowledgments

We thank the Royal Golden Jubilee Scholarship (PHD/0008/2553) and the National Research University Project of Thailand through the Advanced Functional Materials Cluster of Khon Kaen University for financial support. The Center of Excellence for Innovation in Chemistry (PERCH-CIC), Office of the Higher Education Commission, Ministry of Education is gratefully acknowledged.

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Authors and Affiliations

  1. Department of Chemistry and Center of Excellence for Innovation in Chemistry, Natural Products Research Unit, Faculty of Science, Khon Kaen University, Khon Kaen, 40002, Thailand

    Uraiwan Sriphana & Chavi Yenjai

  2. Department of Microbiology, Faculty of Associated Medical Sciences and Centre for Research and Development of Medical Diagnosis Laboratories, Khon Kaen University, Khon Kaen, 40002, Thailand

    Yordhathai Thongsri & Chularut Prariyachatigul

  3. Department of Chemistry, Faculty of Science, Prince of Songkla University, Songkhla, Hat Yai, 90112, Thailand

    Chaveng Pakawatchai

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  1. Uraiwan Sriphana
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  2. Yordhathai Thongsri
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  3. Chularut Prariyachatigul
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  4. Chaveng Pakawatchai
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  5. Chavi Yenjai
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Correspondence to Chavi Yenjai.

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Sriphana, U., Thongsri, Y., Prariyachatigul, C. et al. Clauraila E from the roots of Clausena harmandiana and antifungal activity against Pythium insidiosum . Arch. Pharm. Res. 36, 1078–1083 (2013). https://doi.org/10.1007/s12272-013-0115-5

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  • DOI: https://doi.org/10.1007/s12272-013-0115-5

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