Skip to main content
SpringerLink
Log in

Antiviral activity of Bifidobacterium adolescentis SPM 0214 against herpes simplex virus type 1

  • Research Article
  • Drug Actions
  • Published:
Archives of Pharmacal Research Aims and scope Submit manuscript

An Erratum to this article was published on 06 November 2014

Abstract

Herpes Simplex Virus type 1 (HSV-1) antibodies are found in up to 90 percent of the general population. About 30% of patients who have been exposed to HSV-1 develop recurrent infections, and this degree is continually increasing. In addition, resistance to all major anti-herpetic drugs such as acyclovir (ACV) has been increasingly reported. These observations underscore the importance of discovering new therapeutic tools for the treatment of HSV-1 infections. Bifidobacterium spp. has been studied in various fields including antibacterial and anticancer effect, but the antiviral activity was studied very little. The aim of this study was to test the antiviral activity of Bifidobacterium spp. against HSV-1. The Bifidobacterium adolescentis SPM 0214 used in this study through the screening of 23 Bifidobacterium spp. by plaque assay was assessed the cell viability assay in Vero cells. We also measured the plaque reduction assay and yield reduction assay after B. adolescentis SPM 0214 treatment at concentrations ranging between 10 and 104 μg/mL. The B. adolescentis SPM 0214 was not toxic to Vero cells, and the inhibition of plaque and yield formation was obviously increased compared to those of the control (no additive). Therefore, these results indicate that antiviral activity of B. adolescentis SPM 0214 against HSV-1.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  • Ahn, J. B., Isolation and characterization of Bifidobcterium Producing exopolysaccharide. Food Eng. Prog., 9, 291–296 (2005).

    Google Scholar 

  • Bae, H. S., Shin, M. S., Kim, Y. J., and Back, Y. J., Effects of the lactic acid bacteria administration on fecal microflora and putrefactive metabolites in health adults. J. Appl. Microbiol. Biotechnol., 24, 254–260 (1996).

    Google Scholar 

  • Benedetti, J. K., Zeh, J., and Corey, L., Clinical reactivation of genital herpes simplex virus infection decreases in frequency over time. Ann. Intern. Med., 131, 14–20 (1999).

    PubMed  CAS  Google Scholar 

  • Boehmer, P. E. and Lehman, I. R., Herpes simplex virus DNA relplication. Annu. Rev. Biochem., 66, 347–384 (1997).

    Article  PubMed  CAS  Google Scholar 

  • Bryson, Y., Dillon, M., and Lovett, M., Treatment of first episode genital HSV with oral acyclovir: long term followup of recurrences: a preliminary report. Scand. J. Infect. Dis., 47, 70–75 (1985).

    CAS  Google Scholar 

  • Chatis, P. A., Miller, C. H., Shrager, L. E., and Crumparker, C. S., Successful treatment with foscarnet of an acyclovir resistant mucocutaneus infection with herpes simplex virus in a patient with acquired immunodeficiency syndrome. N. Engl. J. Med., 320, 297–300 (1989).

    Article  PubMed  CAS  Google Scholar 

  • Coen, D. M. and Schaffner, P. A., Two distinct loci confer resistance to acycloguanosine in herpes simplex virus type. Proc. Natl. Acad. Sci. U. S. A., 77, 2265–2269 (1980).

    Article  PubMed  CAS  Google Scholar 

  • Cross, M. L., Immunoregulation by probiotic lactobacilli: pro-Thl signals and their relevance to human health. Clin. Appl. Immunol. Rev., 3, 115–125 (2002).

    Article  CAS  Google Scholar 

  • De Logu, A., Williamson, R. A., Rozenshteyn Rm Ramirolbanez, F., Simpson, C. D., Burton, D. R., and Sanna, P. P., Characterization of a type-common human recombinant monoclonal to herpes simplex virus with high therapeutic potential. J. Clin. Microbiol., 36, 3198–3204 (1998).

    PubMed  Google Scholar 

  • Donohue, D. C. and Salminen, S., Safety of probiotic bacteria. Asia Pac. J. Clin. Nutr., 5, 25–28 (1996).

    Google Scholar 

  • Donohue, D. C., Salminen, S., and Marteau, P., Safety of probiotic bacteria. In Salminen, S. and von Wright, A. (Eds.). Lactic Acid Bacteria: Microbiology and Functional Aspects. Marcel Dekker, New York, pp. 369–386, (1998).

    Google Scholar 

  • Edwin, G., Barry, M., Tom, M., Jianhua, C., George, H., John, R., and Stephen, S., Evaluation of dendrimer SPL7013, a lead micobicide candidate against herpes simplex viruses. Antiviral. Res., 68, 139–146 (2005).

    Article  Google Scholar 

  • FAO/WHO, Joint FAO/WHO Working Group Report on Drafting Guidelines for the Evaluation of Probiotics in Food. ftp://ftp.fao.org/es/esn/food/wgreport2.pdf (2002).

  • Gibbs, J. S., Chiou, H. C., Bastow, K. F., Cheng, Y. C., and Coen, D. M., Identification of amino acids in herpes simplex virus DNA polymerase involved in substrate and drug recognition. Proc. Natl. Acad. Sci., U. S. A., 85, 6672–6676 (1988).

    Article  PubMed  CAS  Google Scholar 

  • Gismongo, M. R., Drago, L., and Lombardi, A., Review of probiotics available to modify gastrointestinal flora. Int. J. Antimicrob. Agents, 12, 287–292 (1999).

    Article  Google Scholar 

  • Hwang, C. B., Ruffner, K. L., and Coen, D. M., A point mutation within a distinct conserved region of the herpes simplex virus DNA polymerase gene confers drug resistance. J. Virol., 66, 1774–1776 (1992).

    PubMed  CAS  Google Scholar 

  • Kaila, M., Isolauri, E., Soppi, E., Virtanen, E., Laine, S., and Arvilommi, H., Enhancement of circulating antibody secreting cell response in human diarrhea by a human Lactobacillus strain. Pediatric. Res., 32, 141–144 (1992).

    Article  CAS  Google Scholar 

  • Kaila, M., Isolauri, E., Saxelin, M., Arvilommi, H., and Vsikari, T., Viable versus inactivated Lactobacillus strain GG in acute rotavirus diarrhea. Arch. Dis. Child., 72, 51–53 (1995).

    Article  PubMed  CAS  Google Scholar 

  • Kidd, P., Th1/Th2 balance: the hypothesis, its limitations, and implications for health and disease. Altern. Med. Rev., 8, 223–246 (2003).

    PubMed  Google Scholar 

  • Lee, W. K., Lee, S. M., Bae, S. H., and Baek, Y. J., Effect of Bifidobacterium longum HY8001 administration on human fecal bacterial enzymes and microflora. J. Appl. Microbiol. Biotechnol., 24, 267–272 (1999).

    Google Scholar 

  • Lyu, S. Y., Rhim, J. Y., and Park, W. B., Antiherpetic activities of flavonoids against herpes simplex virus type 1 (HSV-1) and type 2 (HSV-2) in vitro. Arch. Pharm. Res., 28, 1293–1301 (2005).

    Article  PubMed  CAS  Google Scholar 

  • Marteau, P. and Salminen, S., Demonstration of safety of probiotics. Demonstraion of nutritional functionality of probiotics foods. Newsletter, 2, 3–8 (1997).

    Google Scholar 

  • Mombelli, B. and Gismondo, M. R., The use of probiotics in medical practice. Int. J. Antimicrob. Agents, 16, 531–536 (2000).

    Article  PubMed  CAS  Google Scholar 

  • Nugier, F., Colin, J. N., Ayamard, M., and Langlois, M., Occurrence and characterization of acyclovir-resistance herpes simplex isolates:report on a two-year sensitivity screening survey. J. Med. Virol., 36, 1–12 (1992).

    Article  PubMed  CAS  Google Scholar 

  • Padgett, D. A., Sheridan, J. F., Dorne, J., Berntson, G. G., Candelora, J., and Glaser, R., Social stress and the reactivation of latent herpes simplex virus type 1. Proc. Natl. Acad. Sci. U. S. A., 95, 7231–7235 (1998).

    Article  PubMed  CAS  Google Scholar 

  • Parente, E. and Ricciardi, A., Production, recovery and purification of bacteriocins from lactic acid bacteria. J. Appl. Microbiol. Biotechnol., 52, 628–638 (1999).

    Article  CAS  Google Scholar 

  • Penner, R., Fedorak, R. N., and Madsen, K. L., Probiotics and nutraceuticals: non-medicinal treatments of gastrointestinal diseases. Curr. Opin. Pharmacol., 5, 596–603 (2005).

    Article  PubMed  CAS  Google Scholar 

  • Prichard, M. N., Turk, S. R., Coleman, L. A., Engelhardt, S. L., Shipman, C., Jr., and Drach, J. C., A microtiter virus yield reduction assay for the evaluation of antiviral compounds against human cytomegalovirus and herpes simplex virus. J. Virol. Methods., 28, 101–106 (1990).

    Article  PubMed  CAS  Google Scholar 

  • Raguin, G. and Malkin, J. E., Genital herpes:epidemiology and pathophysiology. Update and new perspectives. Ann. Med. Interne. (Paris), 148, 530–533 (1997).

    CAS  Google Scholar 

  • Saddi, M., Sanna, A., Cottiglia, F., Chisu, L., Casu, L., Bonsignore, L., and De Logu, A., Antiherpevirus activity of Artemisia arborescens essential oil and inhibition of lateral diffusion in Vero cells. Ann. Clin. Microbiol. Antimicrob., 6, 10 (2007).

    Article  PubMed  Google Scholar 

  • Safrin, S., Kemmerly, S., Plotkin, B., Smith, T., Weissbach, N., De Veranez, D., Phan, L. D., and Cohn, D., Foscarnetresistant herpes simplex virus infection in patients with AIDS. J. Infect. Dis., 169, 193–196 (1994).

    Article  PubMed  CAS  Google Scholar 

  • Salminen, S., Bouley, C., Boutron-Ruault, M. C., Cummings, J. H., Franck, A., Gibson, G. R., Isolauri, E., Moreau, M. C., Roberfroid, M. B., and Rowland, I., Gastrointestinal physiology and function. Br. J. Nutr., 80(Suppl), 147–171 (1998).

    Article  Google Scholar 

  • Salminen, S. J. and Donohue, D. C., Safety assessment of lactobalillus strain GG(ATCC53103). Nutr. Today, 31Suppl 1, 12s–15s (1996).

    Google Scholar 

  • Sanna, P. P., De Logu, A., Williamson, R. A., Hom, Y. L., Straus, S. E., Bloom, F. E., and Burton, D. R., Protection of nude mice by passive immunization with a type common human recombinant monoclonal antibody against HSV. Virology, 215, 101–106 (1996).

    Article  PubMed  CAS  Google Scholar 

  • Scardovi, V., Genus Bifidobacterium Orla-Jensen 1924 472AL. In Sneath, P. H. A., Mair, N. S., Sharpe, M. E., and Holt, J. G. (Eds.). Bergey’s Manual of Systemic Bacteriology. Williams & Willikins, Baltimore, pp. 1418–1434, (1986).

    Google Scholar 

  • Siegel, M. A., Diagnosis and management of recurrent herpes simplex infections. J. Am. Dent. Assoc., 133, 1245–1249 (2002).

    PubMed  Google Scholar 

  • Silva, M., Jacobus, N. V., Deneke, C., and Gorbach, S. L., Antimicrobial substance from a human Lactobacillus strain. Antimicrob. Agents Chemother., 31, 1231–1233 (1987).

    Article  PubMed  CAS  Google Scholar 

  • Straus, S. E., Seidlin, M., Takiff, H. E., Bachrach, S., Di-Giovanna, J. J., Western, K. A., Creagh-Kirk, T., Lininger, L., and Alling, D. W., Suppression of recurrent genital herpes with oral acyclovir. Trans. Assoc. Am. Physicians., 96, 278–283 (1983).

    PubMed  CAS  Google Scholar 

  • Tahara, T. and Kanatani, K., Isolation and partial characterization of cripacin A, a cell-associated bacteriocin produced by Bactibacillus cripatus JCM 2009. FEMS Microbiol. Lett., 147, 287–290 (1997).

    Article  CAS  Google Scholar 

  • Tahri, K., Grill, J. P., and Schneider, F., Involvement of trihydroxy-conjugated bile salts in cholesterol assimilation by Bifidobactera. Curr. Microbiol., 34, 79–84 (1997).

    Article  PubMed  CAS  Google Scholar 

  • You, H. J., Oh, D. K., and Ji, G. E., Anticancerogenic effect of a novel chiroinositol-containing polysaccharide from Bifidobacterium bifidum BGN4. FEMS Microbiol. Lett., 240, 131–136 (2004).

    Article  PubMed  CAS  Google Scholar 

  • Whitley, R. J., Herpes simplex viruses. In Fields, B. N., Knipe, D. M., Howley, P. M., Chanock, R. M., Monath, T. P., Melnick, J. L., Roizman, B., and Straus, S. E. (Eds.). Fields Virology. Lippincott Williams and Wilkins, New York, pp. 2297–2341, (1996).

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Pharmacy, Sahmyook University, Seoul, 139-742, Korea

    Hyang Mi An, Do Kyung Lee, Jung Rae Kim, Si Won Lee, Min Kyeong Cha & Nam Joo Ha

  2. Department of Life Science, Sahmyook University, Seoul, 139-742, Korea

    Kang Oh Lee

  3. Department of Pharmacy, Sahmyook University, San 26-21, Kongreung-2 Dong, Nowon-Gu, Seoul, 139-742, Korea

    Nam Joo Ha

Authors
  1. Hyang Mi An
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Do Kyung Lee
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Jung Rae Kim
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Si Won Lee
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Min Kyeong Cha
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Kang Oh Lee
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Nam Joo Ha
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Nam Joo Ha.

Additional information

An erratum to this article is available at http://dx.doi.org/10.1007/s12272-014-0514-2.

Rights and permissions

Reprints and permissions

About this article

Cite this article

An, H.M., Lee, D.K., Kim, J.R. et al. Antiviral activity of Bifidobacterium adolescentis SPM 0214 against herpes simplex virus type 1. Arch. Pharm. Res. 35, 1665–1671 (2012). https://doi.org/10.1007/s12272-012-0918-9

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s12272-012-0918-9

Key words

Search

Navigation