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The antidiabetic effect of ginsenoside Rb2 via activation of AMPK

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Abstract

Ginsenosides, which are active compounds found in ginseng (Panax ginseng), are used as antidiabetic treatments. The aim of this study was to determine whether Rb2, a type of ginsenoside, regulates hepatic gluconeogenesis through AMP-activated protein kinase (AMPK) and the orphan nuclear receptor small heterodimer partner (SHP) in hyperlipidemic conditions used as an in vitro model of type 2 diabetes. Considering these results, we concluded that Rb2 may inhibit palmitate-induced gluconeogenesis via AMPK-induced SHP by relieving ER stress, a cause of gluconeogenesis.

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Authors and Affiliations

  1. College of Pharmacy, Chung-Ang University, Seoul, 156-756, Korea

    Kyoung-Tae Lee, Seul-Gi Kim & Wan-Kyunn Whang

  2. Integrated Bioscience and Biotechnology Institute, College of Pharmacy, Seoul National University, Seoul, 151-742, Korea

    Tae Woo Jung

  3. Division of Green Business Management, Korea Forest Research Institute, Seoul, 130-712, Korea

    Hak-Ju Lee

  4. Department of Herbal Corp Research, Eum Seong, 369-873, Korea

    Yu-Su Shin

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  1. Kyoung-Tae Lee
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  2. Tae Woo Jung
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  3. Hak-Ju Lee
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  4. Seul-Gi Kim
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Correspondence to Wan-Kyunn Whang.

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Lee, KT., Jung, T.W., Lee, HJ. et al. The antidiabetic effect of ginsenoside Rb2 via activation of AMPK. Arch. Pharm. Res. 34, 1201–1208 (2011). https://doi.org/10.1007/s12272-011-0719-6

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  • DOI: https://doi.org/10.1007/s12272-011-0719-6

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