Abstract
In the course of searching for cholesteryl ester transfer protein (CETP) inhibitors from natural sources, a new type of CETP inhibitor, [10]-dehydrogingerdione (1), was isolated from the extract of rhizomes of Zingiber officinale Roscoe. By NMR spectroscopic analysis of its 1HNMR, 13C-NMR, and 1H-1H COSY, HMBC, HMQC and NOESY, more precise structure, compared with its originally proposed structures, of [10]-dehydrogingerdione has been elucidated. This active compound inhibited human plasma CETP with IC50 values of 35 μM.
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Choi, SY., Park, GS., Lee, S.Y. et al. The conformation and CETP inhibitory activity of [10]-dehydrogingerdione isolated from Zingiber officinale . Arch. Pharm. Res. 34, 727–731 (2011). https://doi.org/10.1007/s12272-011-0505-5
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DOI: https://doi.org/10.1007/s12272-011-0505-5