Abstract
Five flavonoids, myricetin-3′-methylether 3-O-β-d-galactopyranoside (1), myricetin-3′,5′-dimethylether 3-O-β-d-galactopyranoside (2), quercetin (3), kaempferol (4), and tamarixetin (5) were isolated from the buds of Cleistocalyx operculatus (Myrtaceae). The chemical structures of these compounds were determined on the basis of spectroscopic analyses, including 2D NMR. Their anti-Alzheimer effects were evaluated via acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibitory activity assays. All five compounds 1–5 showed potential inhibitory activities against AChE with IC50 values of 19.9, 37.8, 25.9, 30.4 and 22.3 μM, respectively, while compounds 1, 3, 4 and 5 also possessed BChE inhibitory activity with IC50 values of 152.5, 177.8, 62.5, and 160.6 μM, respectively.
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Min, B.S., Cuong, T.D., Lee, JS. et al. Cholinesterase inhibitors from Cleistocalyx operculatus buds. Arch. Pharm. Res. 33, 1665–1670 (2010). https://doi.org/10.1007/s12272-010-1016-5
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DOI: https://doi.org/10.1007/s12272-010-1016-5