Abstract
A new isoflavone glycoside, 6-methoxy-7-hydroxy-4′-O-β-d-glucosyl isoflavone, glycitein-4′-O-β-d-glucoside (10), along with nine known flavonoids, were isolated from the stem bark of Sophora japonica. The structures of these compounds were determined by analysis of spectroscopic data (1D -, 2D - NMR and HRMS). The inhibitory effects of all the isolated compounds on aldose reductase were evaluated in vitro. Among these compounds, daidzein (1), puerol A (4), and paratensein-7-O-glucoside (9) exhibited potent inhibitory effects, with IC50 values of 3.2, 6.4, and 1.9 μM, respectively.
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Park, H.Y., Kim, S.H., Kim, G.B. et al. A new isoflavone glycoside from the stem bark of Sophora japonica . Arch. Pharm. Res. 33, 1165–1168 (2010). https://doi.org/10.1007/s12272-010-0805-1
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DOI: https://doi.org/10.1007/s12272-010-0805-1