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Farnesyl protein transferase inhibitory components of Polygonum multiflorum

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Abstract

The methanolic extract of the roots of Polygonum multiflorum (Polygonaceae) was found to show inhibitory activity towards farnesyl protein transferase (FPTase). Bioassay-guided fractionation of the methanolic extract resulted in the isolation of two anthraquinone glycosides, as inhibitors of FPTase. These compounds inhibited the FPTase activity in a dose-dependent manner.

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Authors and Affiliations

  1. College of Pharmacy, Woosuk University, Samrye, 565-701, Korea

    Sa Im Lee, Eun Jeong Kim, Jae Heon Yang, Byeong Suk Chae & Dae Keun Kim

  2. Korea Research Institute of Bioscience and Biotechnology, KIST, Daejeon, 305-333, Korea

    Byoung-Mog Kwon

  3. Lab. of Angiogenesis and Chemoprevention, Department of Oriental Pathology, College of Oriental Medicine, Kyunghee University, Seoul, 131-701, Korea

    Sung-Hoon Kim

  4. Graduate School of Biotechnology & Plant Metabolism Research Center, KyungHee University, Suwon, 449-701, Korea

    Nam-In Baek

  5. Department of Oriental Pharmaceutical Development, Nambu University, Gwangju, 506-706, Korea

    Jae Hyeok Lee

  6. Department of Oriental Alternative Medicine, Nambu University, Gwangju, 506-706, Korea

    Hee Wook Park & Jeong-Suk Park

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  1. Byoung-Mog Kwon
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  2. Sung-Hoon Kim
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  4. Sa Im Lee
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  11. Dae Keun Kim
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Correspondence to Dae Keun Kim.

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Kwon, BM., Kim, SH., Baek, NI. et al. Farnesyl protein transferase inhibitory components of Polygonum multiflorum . Arch. Pharm. Res. 32, 495–499 (2009). https://doi.org/10.1007/s12272-009-1403-y

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  • DOI: https://doi.org/10.1007/s12272-009-1403-y

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