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Prediction of 5-Year Mortality in Patients with Chronic Coronary Syndrome Treated with Elective Percutaneous Coronary Intervention: Role of the ACEF Score

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Abstract

We evaluated the predictive power of age, creatinine, and ejection fraction (ACEF) score on mortality at 5-year follow-up in a population of 471 patients with chronic coronary syndrome (CCS) treated with percutaneous coronary intervention (PCI). Patients in the ACEF-High tertile showed the highest incidence of death at 5 years (15.7% vs. 2.6% in ACEF-Low and 4.3% in ACEF-Mid; log rank p<0.001). The ACEF score could significantly discriminate between patients who died and those who were still alive at 5 years (AUC 0.741, 95% CI 0.654-0.828), and an ACEF score >1.32 was identified as the optimal cutoff point to predict 5-year mortality (sensitivity 74%, specificity 68%). An ACEF score >1.32 was an independent predictor of 5-year mortality (HR 5.77, 95% CI 2.70-12.31; p<0.001). Our study shows that the ACEF score can predict mortality at 5-year follow-up in patients with CCS treated with PCI.

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Abbreviations

ACEF:

age, creatinine, ejection fraction

ACS:

cute coronary syndrome

BMS:

bare metal stent

CABG:

coronary artery bypass grafting

CCS:

chronic coronary syndrome

DES:

drug eluting stent

EF:

ejection fraction

GFR:

glomerular filtration rate

MACE:

major adverse cardiovascular events

MI:

myocardial infarction

PCI:

percutaneous coronary intervention

ST:

stent thrombosis

TIMI:

thrombolysis in myocardial infarction

TVR:

target vessel revascularization

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Authors and Affiliations

  1. Unit of Cardiovascular Science, Department of Medicine, Campus Bio-Medico University, Via Álvaro del Portillo, 200, 00128, Rome, Italy

    Luca Paolucci, Fabio Mangiacapra, Michele Mattia Viscusi, Edoardo Bressi, Iginio Colaiori, Elisabetta Ricottini, Ilaria Cavallari, Annunziata Nusca, Rosetta Melfi, Gian Paolo Ussia & Francesco Grigioni

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  1. Luca Paolucci
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  2. Fabio Mangiacapra
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  3. Michele Mattia Viscusi
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Correspondence to Fabio Mangiacapra.

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Associate Editor Angela Taylor oversaw the review of this article

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Paolucci, L., Mangiacapra, F., Viscusi, M.M. et al. Prediction of 5-Year Mortality in Patients with Chronic Coronary Syndrome Treated with Elective Percutaneous Coronary Intervention: Role of the ACEF Score. J. of Cardiovasc. Trans. Res. 14, 1125–1130 (2021). https://doi.org/10.1007/s12265-021-10122-y

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