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Concept, Evaluation, and Future Perspectives of PERKAT® RV—A Novel Right Ventricular Assist Device

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Abstract

Right heart failure (RHF) is a life-threatening condition. Mechanical right heart support offers an option for critically ill patients. The PERKAT® RV device is designed for percutaneous implantation in acute RHF. It consists of a nitinol chamber covered by foils containing inflow valves. An outlet tube is attached to its distal tip. Using an 18F sheath, it is implanted in the inferior vena cava while the tube bypasses the right heart with its tip in the pulmonary trunk. Then, an IABP balloon is inserted in the pump chamber. Balloon deflation generates blood inflow into the chamber; during inflation, blood is pumped into the pulmonary arteries. The device is capable of achieving flow rates of up to 3.5 l/min under in vitro conditions. In vivo, we were able to increase cardiac output by 59% in a sheep model of acute pulmonary embolism. Based on this, our further research will focus on first-in-human implants.

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Abbreviations

IABP:

Intra-aortic balloon pump

LVAD:

Left ventricular assist device

PERKAT RV:

Percutanous catheter technology right ventricular

RVAD:

Right ventricular assist device

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Acknowledgements

The PERKAT RV device was developed and designed in cooperation with Novapump GmbH (Jena, Germany). We thank Ronald Reich, Joerg Pfeifer, Patrick Patzer, and Yu-Jin Heinekamp. The team from Novapump has significantly contributed to the development and testing of PERKAT RV and has been working closely with the authors to implement the suggestions for improved handling of the device.

Funding

This study was supported by the German Ministry of Education and Research (BMBF-PERKAT-13GW0013C).

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Authors and Affiliations

  1. Department of Internal Medicine I, University Hospital Jena, Friedrich-Schiller-University Jena, Am Klinikum 1, 07740, Jena, Germany

    Daniel Kretzschmar & P. Christian Schulze

  2. HSK, Department of Internal Medicine I, Helios-Clinics, Wiesbaden, Germany

    Markus W. Ferrari

Authors
  1. Daniel Kretzschmar
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  2. P. Christian Schulze
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  3. Markus W. Ferrari
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Corresponding author

Correspondence to Daniel Kretzschmar.

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Conflict of Interest

Prof. Dr. Dr. M. W. Ferrari is cofounder and shareholder of Novapump. For the remaining authors, no conflicts of interest were declared.

Ethical Approval

All applicable international, national, and institutional guidelines for the care and use of laboratory animals were followed and approved by the appropriate institutional committees. Permission for the animal experiments was obtained from the Governmental Commission for Animal Protection, Free State of Thuringia, Germany (registration number: 02-048/14).

Informed Consent

This article does not contain any studies with human participants performed by any of the authors.

Additional information

Associate Editor Navin Kumar Kapur oversaw the review of this article.

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Kretzschmar, D., Schulze, P.C. & Ferrari, M.W. Concept, Evaluation, and Future Perspectives of PERKAT® RV—A Novel Right Ventricular Assist Device. J. of Cardiovasc. Trans. Res. 12, 150–154 (2019). https://doi.org/10.1007/s12265-018-9834-9

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  • DOI: https://doi.org/10.1007/s12265-018-9834-9

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