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Stem Cell Homing: a Potential Therapeutic Strategy Unproven for Treatment of Myocardial Injury

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Abstract

Despite advances in the prevention and therapeutic modalities of ischemic heart disease, morbidity and mortality post-infarction heart failure remain big challenges in modern society. Stem cell therapy is emerging as a promising therapeutic strategy. Stem cell homing, the ability of stem cells to find their destination, is receiving more attention. Identification of specific cues and understanding the signaling pathways that direct stem cells to targeted destination will improve stem cell homing efficiency. This review discusses the cellular and molecular mechanism of stem cell homing at length in the light of literature and analyzes the problem and considerations of this approach as a treatment strategy for the treatment of ischemic heart disease clinically.

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Acknowledgments

I sincerely thank for the invaluable help from Dr. Xin Chen, who is my supervisor and a fellow at the Collaborative Innovation Center for Cardiovascular Disease Translational Medicine, Nanjing Medical University. I apologize to those whose work cannot be cited or referred in detail by restrictions of space and format.

Funding

This study was funded by Jiangsu Provincial Special Program of Medical Science (BE2015612).

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Authors and Affiliations

  1. Department of Thoracic and Cardiovascular Surgery, Nanjing First Hospital, Nanjing Medical University, 68 Changle Road, Nanjing, 210006, Jiangsu, People’s Republic of China

    Zhonghao Tao, Wen Chen & Xin Chen

  2. National Heart Centre Singapore, 5 Hospital Drive, Singapore, 169609, Singapore

    Shihua Tan

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  1. Zhonghao Tao
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  2. Shihua Tan
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  3. Wen Chen
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  4. Xin Chen
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Correspondence to Xin Chen.

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Tao, Z., Tan, S., Chen, W. et al. Stem Cell Homing: a Potential Therapeutic Strategy Unproven for Treatment of Myocardial Injury. J. of Cardiovasc. Trans. Res. 11, 403–411 (2018). https://doi.org/10.1007/s12265-018-9823-z

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  • DOI: https://doi.org/10.1007/s12265-018-9823-z

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