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Regenerative Therapy for Cardiomyopathies

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Abstract

Despite substantial advances in the development of medical and interventional strategies in ischemic and non-ischemic heart diseases, cardiovascular diseases (CVDs) remain the leading cause of mortality and morbidity worldwide. Stem cell therapy for heart disease has gained traction over the past two decades and is an emerging option for the treatment of myocardial dysfunction. In this review, we summarize the current literature on different types of stem cells and their potential usage in ischemic and non-ischemic heart diseases. We emphasize the clinical utility of stem cells to improve myocardial structural and function, promote microvascular angiogenesis, and diminish scar size and major adverse cardiovascular events. We also discuss the therapeutic potential of microvesicles, such as exosomes, in the treatment of CVDs, which may open novel avenues for further clinical studies.

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Funding

This study was supported by the National Natural Science Foundation of China (nos. 81470391) and the National Natural Science Foundation of China (no. 81528002 to Y.T/Y.H). I. Kim, N.L. Weintraub, and Y. Tang were partially supported by the American Heart Association: GRNT31430008, NIH-AR070029, NIH-HL086555, NIH-HL134354, and NIH-HL12425.

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Authors and Affiliations

  1. Department of Cardiology, Renji Hospital, School of Medicine, Shanghai Jiaotong University, 160, Pujian Road, Shanghai, 200127, China

    Zi Wang, Xuan Su & Meng Jiang

  2. Vascular Biology Center, Medical College of Georgia, Augusta University, Augusta, GA, 30912, USA

    Muhammad Ashraf, Il-man Kim, Neal L. Weintraub & Yaoliang Tang

Authors
  1. Zi Wang
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  2. Xuan Su
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  3. Muhammad Ashraf
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  4. Il-man Kim
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  5. Neal L. Weintraub
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  6. Meng Jiang
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  7. Yaoliang Tang
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Corresponding authors

Correspondence to Meng Jiang or Yaoliang Tang.

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This article does not contain any studies with human participants performed by any of the authors.

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The authors declare that they have no conflict of interest.

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Associate Editor Lei Ye oversaw the review of this article

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Wang, Z., Su, X., Ashraf, M. et al. Regenerative Therapy for Cardiomyopathies. J. of Cardiovasc. Trans. Res. 11, 357–365 (2018). https://doi.org/10.1007/s12265-018-9807-z

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  • DOI: https://doi.org/10.1007/s12265-018-9807-z

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