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Emerging MRI Methods in Translational Cardiovascular Research

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Abstract

Cardiac magnetic resonance imaging (CMR) has become a reference standard modality for imaging of left ventricular (LV) structure and function and, using late gadolinium enhancement, for imaging myocardial infarction. Emerging CMR techniques enable a more comprehensive examination of the heart, making CMR an excellent tool for use in translational cardiovascular research. Specifically, emerging CMR methods have been developed to measure the extent of myocardial edema, changes in ventricular mechanics, changes in tissue composition as a result of fibrosis, and changes in myocardial perfusion as a function of both disease and infarct healing. New CMR techniques also enable the tracking of labeled cells, molecular imaging of biomarkers of disease, and changes in calcium flux in cardiomyocytes. In addition, MRI can quantify blood flow velocity and wall shear stress in large blood vessels. Almost all of these techniques can be applied in both pre-clinical and clinical settings, enabling both the techniques themselves and the knowledge gained using such techniques in pre-clinical research to be translated from the lab bench to the patient bedside.

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Acknowledgments

Work by MHV was supported by American Heart Association pre-doctoral grant AHA0815242E, and by a postdoctoral fellowship from the Whitaker International Fellows and Scholars Program. FHE is supported by NIH R01 EB 001763. The authors would like to acknowledge the contribution of figure material from Michael Salerno, Amy West, Ron Beyers, Patrick Antkowiak, Nivedita Naresh, and Xiao Chen.

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Authors and Affiliations

  1. Department of Biological Regulation, Weizmann Institute of Science, 76100, Rehovot, Israel

    Moriel H. Vandsburger

  2. Departments of Radiology, Biomedical Engineering, and Cardiovascular Research Center, University of Virginia, PO Box 800759, 480 Ray C. Hunt Drive, Charlottesville, VA, 22908, USA

    Frederick H. Epstein

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  1. Moriel H. Vandsburger
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  2. Frederick H. Epstein
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Correspondence to Frederick H. Epstein.

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Vandsburger, M.H., Epstein, F.H. Emerging MRI Methods in Translational Cardiovascular Research. J. of Cardiovasc. Trans. Res. 4, 477–492 (2011). https://doi.org/10.1007/s12265-011-9275-1

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