References
Calvo M, Davies AJ, Hebert HL, Weir GA, Chesler EJ, Finnerup NB. The genetics of neuropathic pain from model organisms to clinical application. Neuron 2019, 104: 637–653.
Wu XB, He LN, Jiang BC, Wang X, Lu Y, Gao YJ. Increased CXCL13 and CXCR5 in anterior cingulate cortex contributes to neuropathic pain-related conditioned place aversion. Neurosci Bull 2019, 35: 613–623.
Finnerup NB, Attal N, Haroutounian S, McNicol E, Baron R, Dworkin RH, et al. Pharmacotherapy for neuropathic pain in adults: a systematic review and meta-analysis. Lancet Neurol 2015, 14: 162–173.
Sun L, Liu R, Guo F, Wen MQ, Ma XL, Li KY, et al. Parabrachial nucleus circuit governs neuropathic pain-like behavior. Nat Commun 2020, 11: 5974.
Chiang MC, Bowen A, Schier LA, Tupone D, Uddin O, Heinricher MM. Parabrachial complex: a hub for pain and aversion. J Neurosci 2019, 39: 8225–8230.
Choi S, Hachisuka J, Brett MA, Magee AR, Omori Y, Iqbal NU, et al. Parallel ascending spinal pathways for affective touch and pain. Nature 2020, 587: 258–263.
Deng J, Zhou H, Lin JK, Shen ZX, Chen WZ, Wang LH, et al. The parabrachial nucleus directly channels spinal nociceptive signals to the intralaminar thalamic nuclei, but not the amygdala. Neuron 2020, 107(909–923): e906.
Rodriguez E, Sakurai K, Xu J, Chen Y, Toda K, Zhao S, et al. A craniofacial-specific monosynaptic circuit enables heightened affective pain. Nat Neurosci 2017, 20: 1734–1743.
Chiang MC, Nguyen EK, Canto-Bustos M, Papale AE, Oswald AM, Ross SE. Divergent neural pathways emanating from the lateral parabrachial nucleus mediate distinct components of the pain response. Neuron 2020.
Palmiter RD. The parabrachial nucleus: CGRP neurons function as a general alarm. Trends Neurosci 2018, 41: 280–293.
Barik A, Thompson JH, Seltzer M, Ghitani N, Chesler AT. A brainstem-spinal circuit controlling nocifensive behavior. Neuron 2018, 100(1491–1503): e1493.
Roeder Z, Chen Q, Davis S, Carlson JD, Tupone D, Heinricher MM. Parabrachial complex links pain transmission to descending pain modulation. Pain 2016, 157: 2697–2708.
Raver C, Uddin O, Ji Y, Li Y, Cramer N, Jenne C, et al. An amygdalo-parabrachial pathway regulates pain perception and chronic pain. J Neurosci 2020, 40: 3424–3442.
Acknowledgements
This Research Highlight was supported by Duke University Anesthesiology Research Funds and the National Natural Science Foundation of China (31771162).
Author information
Authors and Affiliations
Corresponding authors
Rights and permissions
About this article
Cite this article
Wang, Z., Xu, ZZ. The Parabrachial Nucleus as a Key Regulator of Neuropathic Pain. Neurosci. Bull. 37, 1079–1081 (2021). https://doi.org/10.1007/s12264-021-00676-x
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s12264-021-00676-x