Skip to main content
SpringerLink
Log in

Early Intervention in Alzheimer’s Disease: How Early is Early Enough?

  • RESEARCH HIGHLIGHT
  • Published:
Neuroscience Bulletin Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

References

  1. Sun BL, Li WW, Zhu C, Jin WS, Zeng F, Liu YH, et al. Clinical research on Alzheimer’s disease: progress and perspectives. Neurosci Bull 2018, 34: 1111–1118.

    Article  CAS  Google Scholar 

  2. Masters CL, Simms G, Weinman NA, Multhaup G, McDonald BL, Beyreuther K. Amyloid plaque core protein in Alzheimer disease and Down syndrome. Proc Natl Acad Sci U S A 1985, 82: 4245–4249.

    Article  CAS  Google Scholar 

  3. Selkoe DJ, Hardy J. The amyloid hypothesis of Alzheimer’s disease at 25 years. EMBO Mol Med 2016, 8: 595–608.

    Article  CAS  Google Scholar 

  4. Panza F, Lozupone M, Logroscino G, Imbimbo BP. A critical appraisal of amyloid-beta-targeting therapies for Alzheimer disease. Nat Rev Neurol 2019, 15: 73–88.

    Article  Google Scholar 

  5. Egan MF, Kost J, Voss T, Mukai Y, Aisen PS, Cummings JL, et al. Randomized trial of verubecestat for prodromal Alzheimer’s disease. N Engl J Med 2019, 380: 1408–1420.

    Article  CAS  Google Scholar 

  6. Henley D, Raghavan N, Sperling R, Aisen P, Raman R, Romano G. Preliminary results of a trial of atabecestat in preclinical Alzheimer’s disease. N Engl J Med 2019, 380: 1483–1485.

    Article  Google Scholar 

  7. Willem M, Garratt AN, Novak B, Citron M, Kaufmann S, Rittger A, et al. Control of peripheral nerve myelination by the beta-secretase BACE1. Science 2006, 314: 664–666.

    Article  CAS  Google Scholar 

  8. Willem M, Tahirovic S, Busche MA, Ovsepian SV, Chafai M, Kootar S, et al. eta-Secretase processing of APP inhibits neuronal activity in the hippocampus. Nature 2015, 526: 443–447.

    Article  CAS  Google Scholar 

  9. Roberts BR, Lind M, Wagen AZ, Rembach A, Frugier T, Li QX, et al. Biochemically-defined pools of amyloid-beta in sporadic Alzheimer’s disease: correlation with amyloid PET. Brain 2017, 140: 1486–1498.

    Article  Google Scholar 

  10. Selkoe DJ. Alzheimer’s disease: genes, proteins, and therapy. Physiol Rev 2001, 81: 741–766.

    Article  CAS  Google Scholar 

  11. Jonsson T, Atwal JK, Steinberg S, Snaedal J, Jonsson PV, Bjornsson S, et al. A mutation in APP protects against Alzheimer’s disease and age-related cognitive decline. Nature 2012, 488: 96–99.

    Article  CAS  Google Scholar 

  12. McDade E, Wang G, Gordon BA, Hassenstab J, Benzinger TLS, Buckles V, et al. Longitudinal cognitive and biomarker changes in dominantly inherited Alzheimer disease. Neurology 2018, 91: e1295–e1306.

    Article  Google Scholar 

  13. Bu XL, Jiao SS, Lian Y, Wang YJ. Perspectives on the tertiary prevention strategy for Alzheimer’s disease. Curr Alzheimer Res 2016, 13: 307–316.

    Article  CAS  Google Scholar 

Download references

Acknowledgements

This highlight was supported by the National Natural Science Foundation of China (91749206 and 81625007).

Author information

Authors and Affiliations

  1. Department of Neurology and Center for Clinical Neuroscience, Daping Hospital, Third Military Medical University, Chongqing, 400042, China

    Dong-Yu Fan & Yan-Jiang Wang

  2. Chongqing Key Laboratory of Aging and Brain Diseases, Chongqing, 400042, China

    Dong-Yu Fan & Yan-Jiang Wang

Authors
  1. Dong-Yu Fan
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Yan-Jiang Wang
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Yan-Jiang Wang.

Ethics declarations

Conflict of interest

The authors declare that they have no conflict of interests.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Fan, DY., Wang, YJ. Early Intervention in Alzheimer’s Disease: How Early is Early Enough?. Neurosci. Bull. 36, 195–197 (2020). https://doi.org/10.1007/s12264-019-00429-x

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s12264-019-00429-x

Search

Navigation