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Atlas of the Striatum and Globus Pallidus in the Tree Shrew: Comparison with Rat and Mouse

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Abstract

The striatum and globus pallidus are principal nuclei of the basal ganglia. Nissl- and acetylcholinesterase-stained sections of the tree shrew brain showed the neuroanatomical features of the caudate nucleus (Cd), internal capsule (ic), putamen (Pu), accumbens, internal globus pallidus, and external globus pallidus. The ic separated the dorsal striatum into the Cd and Pu in the tree shrew, but not in rats and mice. In addition, computer-based 3D images allowed a better understanding of the position and orientation of these structures. These data provided a large-scale atlas of the striatum and globus pallidus in the coronal, sagittal, and horizontal planes, the first detailed distribution of parvalbumin-immunoreactive cells in the tree shrew, and the differences in morphological characteristics and density of parvalbumin-immunoreactive neurons between tree shrew and rat. Our findings support the tree shrew as a potential model for human striatal disorders.

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Acknowledgements

This study was supported by the National Natural Science Foundation of China (31500859 and 91432305) and the Strategic Priority Research Program of the Chinese Academy of Science (XDB02030001).

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Authors and Affiliations

  1. Psychiatric Laboratory and Mental Health Center, West China Hospital of Sichuan University, Chengdu, 610041, China

    Rong-Jun Ni & Tao Li

  2. Chinese Academy of Science Key Laboratory of Brain Function and Diseases, School of Life Sciences, University of Science and Technology of China, Hefei, 230027, China

    Rong-Jun Ni, Zhao-Huan Huang, Yu Wang & Jiang-Ning Zhou

  3. Huaxi Brain Research Center, West China Hospital of Sichuan University, Chengdu, 610041, China

    Rong-Jun Ni & Tao Li

  4. School of Architecture and Civil Engineering, Chengdu University, Chengdu, 610041, China

    Yu-Mian Shu

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  1. Rong-Jun Ni
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RJN was involved in tissue processing, histochemical analysis, collection and interpretation of data, and writing the manuscript; ZHH and YMS were involved in tissue processing and data interpretation; YW was involved in 3D brain reconstruction; TL was responsible for revising the manuscript; and JNZ was responsible for experimental design and manuscript preparation.

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Correspondence to Jiang-Ning Zhou.

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Ni, RJ., Huang, ZH., Shu, YM. et al. Atlas of the Striatum and Globus Pallidus in the Tree Shrew: Comparison with Rat and Mouse. Neurosci. Bull. 34, 405–418 (2018). https://doi.org/10.1007/s12264-018-0212-z

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