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Prefrontal dysfunction and a monkey model of schizophrenia

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Abstract

The prefrontal cortex is implicated in cognitive functioning and schizophrenia. Prefrontal dysfunction is closely associated with the symptoms of schizophrenia. In addition to the features typical of schizophrenia, patients also present with aspects of cognitive disorders. Based on these relationships, a monkey model mimicking the cognitive symptoms of schizophrenia has been made using treatment with the non-specific competitive N-methyl-D-aspartate receptor antagonist, phencyclidine. The symptoms are ameliorated by atypical antipsychotic drugs such as clozapine. The beneficial effects of clozapine on behavioral impairment might be a specific indicator of schizophrenia-related cognitive impairment.

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Authors and Affiliations

  1. Yunnan Key Laboratory of Primate Biomedical Research, Kunming, 650500, China

    Yuan-Ye Ma

  2. Kunming General Hospital of Chengdu Military Command, Kunming, 650032, China

    Ping Mao

  3. State Key Laboratory of Brain and Cognitive Science, Institute of Biophysics, Chinese Academy of Sciences, Beijing, 100101, China

    Ding Cui, Xu-Dong Zhao & Yuan-Ye Ma

  4. Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, 650223, China

    Yuan-Ye Ma

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  1. Ping Mao
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Correspondence to Yuan-Ye Ma.

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Mao, P., Cui, D., Zhao, XD. et al. Prefrontal dysfunction and a monkey model of schizophrenia. Neurosci. Bull. 31, 235–241 (2015). https://doi.org/10.1007/s12264-014-1506-4

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  • DOI: https://doi.org/10.1007/s12264-014-1506-4

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