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MiR-206 decreases brain-derived neurotrophic factor levels in a transgenic mouse model of Alzheimer’s disease

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Abstract

MicroRNA alterations have been reported in patients with Alzheimer’s disease (AD) and AD mouse models. We now report that miR-206 is upregulated in the hippocampal tissue, cerebrospinal fluid, and plasma of embryonic APP/PS1 transgenic mice. The increased miR-206 downregulates the expression of brain-derived neurotrophic factor (BDNF). BDNF is neuroprotective against cell death after various insults, but in embryonic and newborn APP/PS1 mice it is decreased. Thus, a specific microRNA alteration may contribute to AD pathology by downregulating BDNF.

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Authors and Affiliations

  1. Beijing Obstetrics & Gynecology Hospital, Capital Medical University, Beijing, 100026, China

    Ning Tian

  2. State Key Laboratory of Biomembrane and Membrane Biotechnology, College of Life Sciences, PKU-IDG/McGovern Institute for Brain Research, Peking University, Beijing, 100871, China

    Yan Zhang

  3. The High School affiliated to Renmin University of China, Beijing, 100080, China

    Zeyuan Cao

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  1. Ning Tian
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  2. Zeyuan Cao
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  3. Yan Zhang
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Correspondence to Yan Zhang.

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Tian, N., Cao, Z. & Zhang, Y. MiR-206 decreases brain-derived neurotrophic factor levels in a transgenic mouse model of Alzheimer’s disease. Neurosci. Bull. 30, 191–197 (2014). https://doi.org/10.1007/s12264-013-1419-7

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  • DOI: https://doi.org/10.1007/s12264-013-1419-7

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