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Effects of methylphenidate on resting-state brain activity in normal adults: an fMRI study

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Abstract

Methylphenidate (MPH) is one of the most commonly used stimulants for the treatment of attention deficit hyperactivity disorder (ADHD). Although several studies have evaluated the effects of MPH on human brain activation during specific cognitive tasks using functional magnetic resonance imaging (fMRI), few studies have focused on spontaneous brain activity. In the current study, we investigated the effect of MPH on the intra-regional synchronization of spontaneous brain activity during the resting state in 18 normal adult males. A handedness questionnaire and the Wechsler Adult Intelligence Scale were applied before medication, and a resting-state fMRI scan was obtained 1 h after medication (20 mg MPH or placebo, order counterbalanced between participants). We demonstrated that: (1) there were no significant differences in the performance of behavioral tasks between the MPH and placebo groups; (2) the left middle and superior temporal gyri had stronger MPHrelated regional homogeneity (ReHo); and (3) the left lingual gyrus had weaker MPH-related ReHo. Our findings showed that the ReHo in some brain areas changes with MPH compared to placebo in normal adults, even though there are no behavioral differences. This method can be applied to patients with mental illness who may be treated with MPH, and be used to compare the difference between patients taking MPH and normal participants, to help reveal the mechanism of how MPH works.

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Authors and Affiliations

  1. Department of Public Health, School of Medicine, Zhejiang University, Hangzhou, 310058, China

    Yihong Zhu & Bin Gao

  2. Mental Health and Counseling Center, Zhejiang University, Hangzhou, 310058, China

    Yihong Zhu

  3. Department of Radiology, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, 310009, China

    Jianming Hua, Weibo Liu & Biao Jiang

  4. Hangzhou Normal University, Hangzhou, 310036, China

    Yichao Deng & Yufeng Zang

  5. State Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing, 100875, China

    Lijie Zhang & Yufeng Zang

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  1. Yihong Zhu
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Zhu, Y., Gao, B., Hua, J. et al. Effects of methylphenidate on resting-state brain activity in normal adults: an fMRI study. Neurosci. Bull. 29, 16–27 (2013). https://doi.org/10.1007/s12264-013-1306-2

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