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Research progress on interleukin-33 and its roles in the central nervous system

IL-33 及其在中枢神经系统中作用的研究进展

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Abstract

Interleukin-33 (IL-33), a newly recognized IL-1 family member, is expressed by various tissues and cells. Since it can combine with chromosomes, IL-33 is regarded as an intracellular transcription repressor. Upon proinflammatory stimulation, it is released as an extracellular cytokine to function as an alarmin to dangerous signals. The IL-33 receptor is a heterodimer complex composed of ST2 and the IL-1 receptor accessory protein, the latter being conserved in other IL-1 family members. The IL-33/ST2 signaling pathway plays critical roles in inflammatory and immune diseases, as well as in central nervous system (CNS) diseases. Recently, there has been an increasing focus on IL-33, particularly on its production and functions in the CNS. The present review mainly focuses on progress in research on IL-33, especially its roles in the CNS.

摘要

白介素-33(interleukin-33, IL-33)是IL-1家族的新成员, 在多种细胞和组织中表达。 IL-33能与常染色体结 合, 因此被认为具有抑制核内转录的作用。 当受到炎性刺激时, IL-33可作为危险信号的警报释放到细胞外发挥 细胞因子的作用。 IL-33的受体是由ST2和IL-1受体结合蛋白组成的异物二聚体, 其中IL-1受体结合蛋白是所有白 介素家族受体共有的部分。 IL-33/ST2信号通路通过调节细胞因子的生成, 不仅对炎症、免疫性疾病发挥关键作 用, 还参与了许多其他疾病如中枢神经系统疾病。 近年来有关IL-33尤其是它在中枢神经系统中表达及功能的研 究不断增多, 本文对IL-33及其在中枢神经系统中的作用进行了综述。

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Authors and Affiliations

  1. Department of Integrative Medicine and Neurobiology, Institute of Acupuncture Research, State Key Laboratory of Medical Neurobiology, Institutes of Brain Science, Shanghai Medical College, Fudan University, Shanghai, 200032, China

    Ping Han  (韩萍), Wen-Li Mi  (米文丽) & Yan-Qing Wang  (王彦青)

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  1. Ping Han  (韩萍)
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Correspondence to Wen-Li Mi  (米文丽).

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Han, P., Mi, WL. & Wang, YQ. Research progress on interleukin-33 and its roles in the central nervous system. Neurosci. Bull. 27, 351–357 (2011). https://doi.org/10.1007/s12264-011-1025-5

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