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Epigenetics and neural stem cell commitment

表观调控与神经干细胞分化

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Abstract

Neural stem cell is presently the research hotspot in neuroscience. Recent progress indicates that epigenetic modulation is closely related to the self-renewal and differentiation of neural stem cell. Epigenetics refer to the study of mitotical/meiotical heritage changes in gene function that cannot be explained by changes in the DNA sequence. Major epigenetic mechanisms include DNA methylation, histone modification, chromatin remodeling, genomic imprinting, and non-coding RNA. In this review, we focus on the new insights into the epigenetic mechanism for neural stem cells fate.

摘要

神经干细胞是当前神经科学领域的研究热点。 最近的研究显示表观调控与神经干细胞的分化关系密切, 而且为神经干细胞的移植治疗提供可能的细胞来源。 表观调控是指在基因的DNA序列未改变的情况下, 基因功能发生可遗传的变化而导致细胞表型发生改变, 主要机制包括 DNA 甲基化、 组蛋白修饰、 基因印迹、 染色体重组以及非编码小 RNA 等。 本综述就表观调控对神经干细胞分化作用的最新进展作一回顾。

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Authors and Affiliations

  1. Department of Neurosurgery, Fudan University, Huashan Hospital, Shanghai, 200040, China

    Hai-Liang Tang  (汤海亮) & Jian-Hong Zhu  (朱剑虹)

  2. National Key Laboratory for Medical Neurobiology, Shanghai Medical College, Fudan University, Shanghai, 200032, China

    Hai-Liang Tang  (汤海亮) & Jian-Hong Zhu  (朱剑虹)

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  1. Hai-Liang Tang  (汤海亮)
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Correspondence to Jian-Hong Zhu  (朱剑虹).

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Tang, HL., Zhu, JH. Epigenetics and neural stem cell commitment. Neurosci. Bull. 23, 241–248 (2007). https://doi.org/10.1007/s12264-007-0036-8

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  • DOI: https://doi.org/10.1007/s12264-007-0036-8

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