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Protective effect of epigallocatechin-3-gallate on ischemia/reperfusion-induced injuries in the heart: STAT1 silencing flavonoid

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Abstract

The beneficial effect of naturally occurring flavonoids in health is believed to be due to their strong antioxidant activity. However, recent laboratory evidence indicates the involvement of a more specific action. Here, we present evidence that, among a number of catechins present in green tea extract, only epigallocatechin-3-gallate (EGCG) exerts a strong inhibitory action on interferon-γ-elicited activation of signal transducer and activator of transcription 1 (STAT1). Protective action of EGCG in ischemia/reperfusion injury in the heart and the molecular mechanism of action, which has nothing to do with its anti-oxidant capacity are described.

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Acknowledgments

The authors are thankful for the financial support by CariVerona Project 2001 and FIRB 2001 for the completion of this work.

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Authors and Affiliations

  1. Section of Biochemistry, Department of Morphological and Biomedical Sciences, University of Verona, Verona, Italy

    Elena Darra, Kazuo Shoji, Sofia Mariotto & Hisanori Suzuki

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  1. Elena Darra
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  2. Kazuo Shoji
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  3. Sofia Mariotto
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  4. Hisanori Suzuki
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Correspondence to Hisanori Suzuki.

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Darra, E., Shoji, K., Mariotto, S. et al. Protective effect of epigallocatechin-3-gallate on ischemia/reperfusion-induced injuries in the heart: STAT1 silencing flavonoid. Genes Nutr 2, 307–310 (2007). https://doi.org/10.1007/s12263-007-0060-3

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  • DOI: https://doi.org/10.1007/s12263-007-0060-3

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