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Influence of Heparanase and VEGF-C mRNA Expressions in Lung Cancer

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Abstract

The objective of this study is to investigate relationship between the expressions of heparanase and vascular endothelial growth factor-C (VEGF-C) mRNA and tumorigenesis, progression in human lung cancer. The expressions of heparanase and VEGF-C mRNA in 65 cases of lung cancer (31 cases of squamous cell carcinoma, 25 adenocarcinoma, 3 large cell carcinoma, and 6 small cell carcinoma), adjacent tissues of cancer, and normal tissues were tested by reverse transcription-polymerase chain reaction (RT-PCR) and analyzed by clinico-pathological characteristics and prognosis of lung cancer. The rate of expressions of heparanase and VEGF-C mRNA in tumor tissues (55.4, 61.5 %) was significantly higher than that in adjacent tissues of cancer (12.3, 15.4 %) and normal tissues (3.1, 4.6 %) (P < 0.05). It was shown that heparanase and VEGF-C mRNA expressions did not correlate with the pathological type and grade of the tumor (P > 0.05), but they correlated with the clinical stage and survival time of the patients (P < 0.05). Overexpression of heparanase and VEGF-C mRNA in lung cancer tissues perhaps participates in regulation of tumorigenesis and progression. The expressions of heparanase and VEGF-C mRNA should be used as a useful marker of the biological behavior of lung cancer and as an independent prognosis factor for the patient’s survival.

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Acknowledgments

The authors wish to thank Tian Hui (of the Thoracic Department of Qilu Hospital) for his continued support and major contributions to this research work. The authors also wish to express special thanks to Guo Jiazhong (Division of Thoracic Surgery, Shandong University) for data management and outstanding technical assistance. Regarding funding, this piece of his research was supported by the Science and Technology Agency of Shandong Province, the People’s Republic of China.

Conflict of Interest

The authors declare that they have no competing interest.

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Authors and Affiliations

  1. Thoracic Department, Xinjiang Uygur Autonomous Region People’s Hospital, Urumqi, China

    Yongwei Yang, Xiaokaiti Maimaitiyiming, Chengyu Jin, Nuerlan Ahan & Rui Guo

  2. Thoracic Department, The second Hospital of Shandong University, 247, Beiyuan Street, Jinan, China

    Chuanliang Peng

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  1. Yongwei Yang
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  2. Xiaokaiti Maimaitiyiming
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  3. Chengyu Jin
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  4. Nuerlan Ahan
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  5. Rui Guo
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  6. Chuanliang Peng
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Correspondence to Chuanliang Peng.

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Yang, Y., Maimaitiyiming, X., Jin, C. et al. Influence of Heparanase and VEGF-C mRNA Expressions in Lung Cancer. Indian J Surg 77, 477–480 (2015). https://doi.org/10.1007/s12262-015-1291-y

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  • DOI: https://doi.org/10.1007/s12262-015-1291-y

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