Abstract
Background
The etiopathological role of human papilloma virus (HPV) in the causation of oral cancer is till a subject of speculation.
Methods
We used the technique of Southern blot hybridization to detect the presence of HPV types 16 & 18 in biopsy specimens from oral cancer and leukoplakia patients as well as normal oral mucosal biopsies.
Results
The prevalence of either HPV type 16 or 18 was found in 64.5% (29/45) of oral cancer, 40%(12/30) of leukoplakia and 20%(9/45) of normal oral mucosal biopsies. No association could be demonstrated between tobacco usage habits or a history of genital warts with HPV prevalence.
Conclusion
A significant finding was that none of the oral cancer patients were negative for both: a history of tobacco usage as well as presence of HPV infection, on Southern blot hybridization.
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Khanna, R., Rao, G.R.K., Tiwary, S.K. et al. Detection of human papilloma virus 16 and 18 DNA sequences by southern blot hybridization in oral leukoplakia and squamous cell carcinoma. Indian J Surg 71, 69–72 (2009). https://doi.org/10.1007/s12262-009-0019-2
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DOI: https://doi.org/10.1007/s12262-009-0019-2